DOI QR코드

DOI QR Code

Anti-Diabetic Effect of Black Ginseng in C57BLKS/J-$db/db$ Mice

C57BLKS/J-$db/db$ 마우스에서 흑삼의 항당뇨 효과

  • Kang, Shin-Jung (Dept. of Medicine Resources, Graduate School of Jungboo University) ;
  • Kim, Ae-Jung (The Graduate School of Alternative Medicine, Kyonggi University)
  • 강신정 (중부대학교 한약자원학과) ;
  • 김애정 (경기대학교 대체의학대학원 대체의학과)
  • Received : 2011.11.22
  • Accepted : 2011.12.09
  • Published : 2011.12.31

Abstract

본 연구는 흑삼의 항당뇨 효과를 알아보고자 4그룹(정상군, 당뇨 쥐, 당뇨 쥐에게 백삼을 투여한 군, 당뇨 쥐에게 흑삼을 투여한 군)으로 나누어 6주간 실시하였다. 6주 후 식품섭취량, 체중 증가량을 비교하였는데, 식품섭취량, 체중 증가량에는 그룹 간에 유의적인 차이가 나타나지 않았으나, OGTT(oral glucose tolerance test)와 IPITT(intraperitoneal insulin tolerance test) 경우는 흑삼 투여군에서 긍정적인 결과를 나타내었다. 또한 혈청 포도당과 인슐린농도에 미친 영향을 비교, 분석한 결과, 흑삼 투여군에서 공복 시 혈당, 혈청 포도당, 인슐린 농도가 유의적으로 감소하였다. 이 결과를 미루어 볼 때 흑삼이 백삼에 비해 당뇨를 치료하는데 더 효과적일 것으로 판단된다.

Keywords

References

  1. Alberti KGMM, Zimmet PZ. 1998. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabetes Med 13: 539-553
  2. Attele AS, Zhou YP, Xie JT, Wu JA, Zhang L, Dey L. 2002. Antidiabetic effects of Panax ginseng berry extract and the indentification of an effective components. Diabetes 51:1851- 1858 https://doi.org/10.2337/diabetes.51.6.1851
  3. D'Agostino RB, Hamman RF, Karter AJ, Mykkanen L, Wagenkencht LE, Haffiner SM. 2004. Cardiovascular disease risk factors predict the development of type 2 diabetes: The insulin resistance atherosclerosis study. Diabetes Care 27: 2234-2240 https://doi.org/10.2337/diacare.27.9.2234
  4. DeFronzo RA. 1988. The triumvirate: Beta-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 37:667-687 https://doi.org/10.2337/diab.37.6.667
  5. Hasegawa H, Sung JH, Huh JD. 1997a. Ginseng intestinal bacteria metabolite IH901 as a new antimetastatic agent. Arch Pharm Res 20:539-544 https://doi.org/10.1007/BF02975208
  6. Kang KS, Kim HY, Pyo JS, Yokozawa T. 2006. Increase in the free radical scavenging activity of ginseng by heat-processing. Biol Pharm Bull 29:750-754 https://doi.org/10.1248/bpb.29.750
  7. Kato A, Miura T. 1994. Hypoglycemic action of rhizomes of polygonatum officinale in normal and diabetic mice. Planta Med 60:201-203 https://doi.org/10.1055/s-2006-959458
  8. Keum YS, Han SS, Chun KS, Park KK, Park JH, Lee SK. 2003. Inhibitory effects of the ginsenoside Rg3 on phorbol esterinduced cyclooxygenase-2 expression, NF-kappaB activation and turmor promotion. Mutat Res 523-524:75-85 https://doi.org/10.1016/S0027-5107(02)00323-8
  9. Kim SN, Kang SJ. 2009. Effects of black ginseng (9 timessteaing ginseng) on hypoglycemic action and changes in the composition of ginsenosides on the steaming process. Korean J Food Sci Technol 41:77-81
  10. Kim SW, Kwon HY, Chi DW, Shim JH, Park JD, Lee YH. 2003. Reversal of P-glycoprotein-mediated multidrug resistance by ginsenoside Rg3. Biochem Pharmacol 65:75-82 https://doi.org/10.1016/S0006-2952(02)01446-6
  11. Lee JH, Shen GN, Kim EK, Shin JH, Myung CS, Oh HJ, Kim DH, Roh SS, Cho W, Seo YB, Park YJ, Kang CW, Song GY. 2006. Preparation of black ginseng and its antitumor activity. Korean J Orient Physiol Pathol 20:951-956
  12. Lenhard JM, Gottschalk WK. 2002. Preclinical development in type 2 diabetes. Advanced Drug Delivery Reviews 54:1199- 1212 https://doi.org/10.1016/S0169-409X(02)00092-3
  13. lvorra MD, Paya M, Villar A. 1989. A review of natural products and plants as potential antidiabetic drugs. J Ethnopgarmacol 27:243-75 https://doi.org/10.1016/0378-8741(89)90001-9
  14. Neef H, Declereq P, laekeman G. 1995. Hypoglycaemic activity of selected European plants. Phutother Res 9:45-48 https://doi.org/10.1002/ptr.2650090111
  15. Noel PH, Pugh JA, Larne AC, Marsh G. 1997. The use of traditional plant medicines for non-insulin dependent diabetes mellitus in South Texas. Phutother Res 11:512-7 https://doi.org/10.1002/(SICI)1099-1573(199711)11:7<512::AID-PTR149>3.0.CO;2-H
  16. Pan XR, Walden CE, Warnick GR, Hu SX, Alberts JJ, Cheung M, Bierman EL. 1986. Comparison of plasma lipoproteins and apoproteins in Chinese and American non-insulin dependent diabetic subjects and controls. Diabetes Care 9: 395-400 https://doi.org/10.2337/diacare.9.4.395
  17. Park SP, Ko SK, Chung SH. 2003. Comparisons of antidiabetic effect between ginseng radix, alba, ginseng radix rubra and Panax quinquefoli radix in MLD STZ-induced diabetic rats. J Ginseng Res 27:56-61 https://doi.org/10.5142/JGR.2003.27.2.056
  18. Peter P, Nuttall SL, Kendall MJ. 2003. Insulin resistance-the new goal! J of Clinical Pharmacy and Therapeutics 28:167-174 https://doi.org/10.1046/j.1365-2710.2003.00482.x
  19. Pi-Sunyer FX. 2002. The obesity epidemic: Pathophysiology and consequences of obesity. Obese Res 210:97S-104
  20. Scheen AJ. 2000. From obesity to diabetes: Why, when and who? Acta Clinica Belgica 55:9-15 https://doi.org/10.1080/17843286.2000.11754266
  21. Seidell JC. 2000. Obesity, insulin resistance and diabetes-a worldwide epidemic. British J of Nutr 83:S5-S8
  22. Soonthornpun S, Rattarasarn C, Leelawattana R, Setasuban W. 1999. Postprandial plasma glucose: A good index of glycemic control in type 2 diabetic patients having near-normal fasting glucose levels. Diabetes Research and Clinical Practice 46:429-449
  23. Turner RC. 1998. The UK prospective diabetes study. A review. Diabetes Care 21:C35-C38 https://doi.org/10.2337/diacare.21.3.C35
  24. Vuksan V, Stavro MP, Sievenpiper JL, Beljan-Zdravkovic U, Leiter LA, Josse RG, Xu Z. 2000. Similar postprandial glycemic reductions with escalation of dose and administration time of American ginseng in type 2 diabetes. Diabetes Care 23:1221-1226 https://doi.org/10.2337/diacare.23.9.1221
  25. Wild S, Roglic G, Green A, Sicree R, King H. 2004. Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care 27:1047-1053. https://doi.org/10.2337/diacare.27.5.1047
  26. Xie JT, Aung HH, Wu JA, Attele AS, Yuan C-S. 2002a. Effects of American ginseng berry extract on blood glucose levels in b/ob mice. Am J Chin Med 30:187-194 https://doi.org/10.1142/S0192415X02000442
  27. Xie JT, Zhou Y-P, Zhang L, Dey L, Attele AS, Wu JA, Gu M. 2002b. Ginseng berry reduces blood glucose and body weight in db/db mice. Phytomedicine 9:254-258 https://doi.org/10.1078/0944-7113-00106
  28. Yun TK. 2003. Experimental and epidemiological evidence on non-organ specific cancer preventive effect of Korean ginseng and identification of active compounds. Mutat Res 523:63-74.16
  29. Zhang Ruxue, Zhou Jinhuang, Jia Zhengping, Zhang Youngxing, Gu Guoming. 2004. Hypoglycemic effect of Rehmannia glutinosa oligosaccharide in hyperglycemic and alloxan-induced diabetic rats and its mechanism. J of Ethnophamacology 90:39-43 https://doi.org/10.1016/j.jep.2003.09.018

Cited by

  1. Inhibitory Activities of Water Extracts of Black Ginseng on HCl/Ethanol-Induced Acute Gastritis through Anti-Oxidant Effect vol.45, pp.9, 2016, https://doi.org/10.3746/jkfn.2016.45.9.1249
  2. 고려인삼과 당뇨병: 세포와 동물 및 인체실험을 통한 고려인삼의 당뇨병에 대한 효능 vol.51, pp.1, 2011, https://doi.org/10.22889/kjp.2020.51.1.001