The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
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Effect of Eicosapentaenoic Acid on Cellular Lipid Accumulation and Transcription Factors Involving Glucose Utilization

에이코사펜타에노익산에 의한 세포 내에서의 지방 축적 억제 효과 및 포도당 대사에 관여하는 전사인자의 변화

  • Bu, So-Young (Major in Food Science and Nutrition, School of Food Science, Kyungil University)
  • 부소영 (경일대학교 식품과학부 식품영양전공)
  • Received : 2011.08.25
  • Accepted : 2011.11.18
  • Published : 2011.12.31
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Abstract

Previous studies suggest that polyunsaturated fatty acids with long carbon chains such as eicosapentaenoic acid(EPA) and docosahexaenoic acid(DHA) have several health benefits. However metabolic consequences of these fatty acids themselves and their regulation of transcriptional activity involving glucose utilization are not well established. Thus, the purpose of this study was to investigate how EPA influx affects cellular lipid accumulation and gene expressions involving $de$ $novo$ lipogenesis in hepatocyte cultures. Compared to oleic acid treatment, EPA treatment showed remarkably decreased cellular TG conversion and accumulation, along with phospholipids at a lower extent. As expected, EPA increased mRNA expression involving fatty acid influx and lipid droplet formation, but did not affect mRNA expression involving glucose utilization. EPA increased transcriptional activity of PPAR-${\alpha}$ and glucose responsive transcription factor when transcription factor binding protein was activated. Taken together, these data suggest that EPA decreases lipid accumulation through increases of the ${\beta}$-oxidation pathway without interruption of glucose utilization.

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References

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