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The Effects of the Physical Activity Program on Body Composition, Depression and Risk Factors of Dementia in the Elderly Women

고령 여성들의 신체활동 프로그램 참여가 신체조성, 우울증 및 치매 위험 인자에 미치는 영향

  • Han, Ji-A (Department of Physical Education Sookmyung University) ;
  • Chung, Ji-Hye (Department of Physical Education Sookmyung University) ;
  • Kim, Duk-Jung (Department of Sports and Leisure, WooSuk University)
  • 한지아 (숙명여자대학교 체육교육학과) ;
  • 정지혜 (숙명여자대학교 체육교육학과) ;
  • 김덕중 (우석대학교 레저스포츠학과)
  • Received : 2010.12.27
  • Accepted : 2011.03.20
  • Published : 2011.03.30

Abstract

The purpose of this study was to examine the effects of a physical activity program on body composition, depression and risk factors of dementia in elderly women. Subjects were 40 women aged 65~75 years, classified into two groups (experiment group 20, control group 20). The factors measured in this study were body composition (weight, percent body fat, body mass index, body fluid), depression (BDI score) and risk factors of dementia (K-MMSE, LDL-C, HDL-C, insulin, ${\beta}$-amyloid, DHEAs) at 12 and 24 weeks before and after the program. Subjects of experiment group participated in a 24 week physical activity program (45~60 min, 3~4 day per weeks). Data were analyzed by repeated ANOVA method of SPSS, with accepting levels for all significances above ${\alpha}$=0.05. The results of this study were as follows. In body composition, the experiment group showed significant differences in the weight, percent body fat and body mass index compared to the control group. In depression score, the experiment group showed no significant differences regarding BDI score level compared to the control group. In risk factors for dementia, the experiment group showed significant differences in levels of K-MMSE, LDL-C, HDL-C, insulin, ${\beta}$-amyloid, and DHEAs compared to the control group. This study showed that a 24 week physical activity program had positive effects on almost all of the factors evaluated in elderly women, and that elderly women who did not participate in the program experiences no such positive effects. Therefore, regular participation in a physical activity program could be advocated as one strategy to enhance body fat, depression, and risk factors of dementia and may result in improving risk for diseases of age in elderly women.

본 연구는 고령 여성들을 대상으로 24주간 신체자극 운동과 걷기 운동의 신체활동 프로그램 병행이 신체조성, 우울증 점수 및 치매 위험 인자의 변화를 규명하고자 하였다. 이를 위해 65~75세의 고령 여성 40명으로서 규칙적인 운동 프로그램에 참여하지 않는 고령 여성들로 실험 집단 20명과 통제 집단 20명, 총 40명을 선정하였다. 24주 간 신체 자극 운동 프로그램은 Kim [33]이 고령자를 대상으로 개발한 프로그램을 수정, 보완하여 운동 빈도는 3~4회/주, 운동시간은 총 45~60분/일으로 하였다. 자료처리는 반복측정에 의한 분산분석(Repeated ANOVA)방법으로 처리한 결과, 다음과 같은 결론을 얻었다. 24주간 신체자극 운동과 걷기 운동의 신체활동 프로그램이 고령 여성들에 있어서 신체조성을 개선시키고, 발생빈도와 재발률이 높고 약물치료가 어려운 음성 증상 중의 하나인 우울증 점수뿐만 아니라, 치매를 예방에 효과적인 결과를 보였다. 그러나 신체적 비활동은 만성질환에 쉽게 노출되는 것으로 나타났다.

Keywords

References

  1. Adlard, P. A, V. M.. Perreau, V. Pop, and C. W. Cotman. 2005. Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease. J. Neurosci. 25, 4217-4221. https://doi.org/10.1523/JNEUROSCI.0496-05.2005
  2. ACSM. 2001. ACSM'S Guideline for Exercise Testing and Prescription, 6th eds., Lippincott Williams and Wilkins. 117.
  3. Balakrishana, K., G. Verdile, P. D. Mehta, J. Beilby, D. Nolan, D. A. Galvao, R. Newton, S. E. Gandy, and R. N. Martins. 2005. Plasma Abeta42 correlates positively with increased body fat in healthy individuals. J. Alzheimers Dis. 8, 269-282.
  4. Beck, A. T. 1967. Depression clinical, experimental and theoretical aspects. New York, Harper and Row Publishers Inc.
  5. Biessels, G. J., S. Staekenborg, E. Brunner, C. Brayne, and P. Scheltens. 2006. Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol. 5, 64-74. https://doi.org/10.1016/S1474-4422(05)70284-2
  6. Bjontorp, P. 1997. Body fat distribution, insulin resistance, and metabolic disease. Nutrition 13, 795-803. https://doi.org/10.1016/S0899-9007(97)00191-3
  7. Blumenthal, J. A., M. A. Babyak, K. A. Moore, W. E. Craighead, S. Herman, P. Khatri, R. Waugh, M. A. Napolitano, L. M. Forman, M. Appelbaum, P. M. Doraiswamy, and K. R. Krishnan. 1999. Effects of exercise training on older patients with major depression. Arch. Intern. Med. 159, 2349-2356. https://doi.org/10.1001/archinte.159.19.2349
  8. Brinton, R. D. 1999. A women's health issue: Alzheimer's disease and strategies for maintaining cognitive health. Int. J. Fertil. Womens Med. 44. 174-185.
  9. Brown, R. C., C. Cascio, and V. Papadopoulos. 2000. Neurosteroids: oxidative stressmediated dehydroepiandrosterone formation in Alzheimer's disease pathology. Neurobiol. Aging 21, S238.
  10. Bruce, R. A., F. Kusumi, and D. Hosmer. 1973. Maximal oxygen intake and normographic assessment of functional aerobic impairment in cardiovascular disease. Am. Heart J. 85, 545.
  11. Bumberry, W., J. M. Oliver, and J. N. McClure. 1978. Validation of the Beck Depression Inventory in a university population using psychiatric estimate as the creterion. J. Concul. Clin. Psych. 46, 150-155. https://doi.org/10.1037/0022-006X.46.1.150
  12. Cedazo-Minguez, A., O. Popescu, J. M. Blanco-Millian, S. Akterin, J. J. Pei, B. Winblad, and R. E. Cowburn. 2003. Apolipoprotein E and beta-amyloid (1-42) regulation of gly, Jen synthase kinase-3beta. J. Neurochem. 87, 1152-1164. https://doi.org/10.1046/j.1471-4159.2003.02088.x
  13. Cha, J. T. and Y. S. Jee. 2004. The effects of regular exercise on cardiovascular function and depression in elderly. Korean J. Physic. Edu. 43, 331-340.
  14. Cho, J. Y., D. Y. Hwang, and T. S. Kang. 2003. Use of NSE/PS2m-transgenic mice in the study of the protective effect of exercise on Alzheimer's disease. J. Sports Sci. 21, 943-951. https://doi.org/10.1080/0264041031000140365
  15. Chodzko-Zajko, W. J. 1990. The influence of general health status on the relationship between chronological age and depressed mood state. J. Geriat. Phych. 23, 13-22.
  16. Chodzko-Zajko, W. J. 1991. Physical fitness, cognitive performance and aging. Med. Sci. Sports Exerc. 23, 868-873.
  17. Choi, J. H., D. W. Kim, J. S. Choi, Y. S. Han, and Y. H. Baek. 1997. Effect of reed root extrac (RRE) on learning and memory impairment animal model SAMP8 strain. III. Feeding effect of RRE on neurotransmitters and their metabolites in SAMP8 brain. Korean J. Gerontol. 7, 29-36.
  18. Choi, S. K. 2001. Effects of an aerobic exercise and diet therapy on visceral fat accumulation and coronary risk factors of the obese women. Korean J. Physic. Edu. 40, 707-717.
  19. Colcombe, S. J. and A. F. Kramer. 2003. Fitness effects on the cognitive function of older adults: a meta-analytic study. Psychol. Sci. 14, 125-130. https://doi.org/10.1111/1467-9280.t01-1-01430
  20. Cole, G. M. and S. A. Frautschy. 2007. The role of insulin and neurotrophic factor signaling in brain aging and Alzheimer's Disease. Exp. Gerontol. 42, 10-21. https://doi.org/10.1016/j.exger.2006.08.009
  21. Despres, J. P., C. Bouchard, and R. M. Malina. 1990. Physical activity and coronary disease rissefactors during childhood and adolescence. Exerc. Sports Sci. Rev. 18, 243-261.
  22. Donna, K. S., B. C. Elizabeth, and C. Catherine. 2001. Cross-sectional and prospective study of exercise and depressed mood in the elderly. Am. J. Epidemiol. 153, 596-603. https://doi.org/10.1093/aje/153.6.596
  23. Fratiglioni, L., S. Paillard-Borg, and B. Winblad. 2004. An active and socially integrated lifestyle in late life might protect against dementia. Lancet Neurol. 3, 343-353. https://doi.org/10.1016/S1474-4422(04)00767-7
  24. Frears, E. R., D. J. Stephens, C. E. Walters, H. Davies, and B. M. Austen. 1999. The role of cholesterol in the biosynthesis of beta-amyloid. Neuroreport. 10, 1699-1705. https://doi.org/10.1097/00001756-199906030-00014
  25. Frisoni, G. B., A. Padovani, and L. O. Walhlund. 2004. The predementia diagnosis of Alzheimer's disease. Alzheimer Dis. Disord. 18, 51-53. https://doi.org/10.1097/01.wad.0000126613.05674.0c
  26. Goodpaster, B. H., C. I. Carlson, M. Visser, D. E. Kelley, A. Scherzinger, T. B. Harris, E. Stamm, and A. B. Newman. 2001. Attenuation of skeletal muscle and strength in the elderly: the health ABC study. J. Appl. Physiol. 90, 2157-2165.
  27. Hakkinen, K., A Pakarinen, W. J. Kraemer, R. U. Newton, and M. Alen. 2000. Basal concentrations and acute responses of serum hormones and strength development during heavy resistance training in middle-aged and elderly men and women. J. Gerontol. Biol. Sci. Med. Sci. 55, B95-105. https://doi.org/10.1093/gerona/55.2.B95
  28. Hong, Y. J. and S. A. Kang. 1998. The Influence of Exercise Continuity on Physical Function and Depression in elder Women. J. Korean Society of Aerobic Exercise 2, 48-55.
  29. Jeon, Y. C. and J. H. Park. 1989. Elderly Korean, Mini-Mental State Exami- nation (MMSE - K) Standardization Research. Neuropsychiatry 28, 508-513.
  30. John, K. A. and B. B. Heather. 1974. The sensitivity of the Beck Depression Inventory to changes of symptomatology. Br. J. Psychiatry. 125, 184-185. https://doi.org/10.1192/bjp.125.2.184
  31. Kang, Y. W. 2006. A normative study of the Korean-mini mental state examination (K-MMSE) in the elderly. Korean J. Psychol. 25, 1-12.
  32. Kim, H. S. and S. K. Hyun. 2004. Effectivenss of exercise training for a short period on functional fitness and depression in the frail elderly. J. Korean Soc. Living. Environ. Sys. 11, 122-128.
  33. Kim, S. H. 2005. The development of gymnastic program for the CVA elderly. J. Sport and Leisure Studies 25, 503-515
  34. Kim, S. Y. 2004. Depression in dementia. Dementia and Neurocognitive Disorders 3, 18-23.
  35. Kim, Y. Y. and Y. J. Kim. 1999. Effects of an aerobic exercise on physical fitness and depression in Schizophrenia patients. Korean J. Sports Medicine. 17, 12-18.
  36. Karvonen, M. and M. O. Kentalak. 1979. The effects of training heart rate, a longitudinal study. Arch. Intern. Med. 139, 857-962. https://doi.org/10.1001/archinte.139.8.857
  37. Kelli, F. K. 2001. The association between physical activity and quality of life in older women. Women's Health Issues 11, 471-480. https://doi.org/10.1016/S1049-3867(01)00128-1
  38. Kirkendall, D. T. and W. E. Garrett. 1998. The effects of aging and training on skeletal muscle. Am. J. Sports Med. 26, 598-602.
  39. Kwon, Y. C. and S. K. Park. 2002. The effects of aerobic exercise on Lymphocyte proliferation and NK cell in elderly women. Korean J. Physical Edu. 41, 543-552.
  40. Kyle, U. G., L. Genton, D. Hans, V. L. Karsegard, J. P. Michel, D. O. Slosman, and C. Pichard. 2001. Total body mass, fat mass, fat-free mass, and skeletal muscle in older people: crossectional differences in 60-years-old persons. J. Am. Geriatr. Soc. 49, 1633-1640. https://doi.org/10.1111/j.1532-5415.2001.49272.x
  41. Laederach-Hofmann, K., S. Kupferschmid, and L. Mussgay. 2002. Links between body mass index, total body fat, cholesterol, high-density lipoprotein and insulin sensitivity in patients with obesity related to depression, anger, and anxiety. Int. J. Eat. Disord. 32, 58-71. https://doi.org/10.1002/eat.10063
  42. LaRue, A., C. Dssonville, and L. F. Jarvik. 1985. Aging and Mental Disorders. In Birren, J. E. and K. W. Schaie (eds.), Handbook of the Physiology of aging. New York: Van Nostrand Reinhold.
  43. Lautenschlager, N. T. and O. P. Almeida. 2006. Physical activity and cognition in old age. Curr. Opin. Psychiatry 19, 190-193. https://doi.org/10.1097/01.yco.0000214347.38787.37
  44. Lee, S. H., D. I. Kim, S. Y. Cho, H. J. Jung, S. M. Cho, H. J. Park, and H. S. Lillehoj. 2005. Effects of acorn (Quercus acutissima CARR.) supplementaion on the level of acetylcholine and its related enzyme activities in the brain of dementia mouse model. J. Korean Soc. Food Sci. Nutr. 34, 738-742. https://doi.org/10.3746/jkfn.2005.34.5.738
  45. Lim, Y. M. 2002. Effects of movenment/exercise on physical and emotional functioning in elders with cognitive impairments. J. Korea Gerontol. Soc. 21, 197-211
  46. Linda, E., B. B. Carlson, and H. M. Sherwin. 1999. Relationships between Dehydroepiandrosterone Sulfate (DHEAs) and cortisol(CRT) plasma levels and everyday memory in Alzheimer's disease patients compared to healthy controls. Hormones Behavior 35, 254-263. https://doi.org/10.1006/hbeh.1999.1518
  47. Mather, A. S., C. Rodriguez, M. F. Guthrie, A. M. McHarg, I. C. Reid, and M. E. McMurdo. 2002. Effects of exercise on depressive symptoms in older adults with poorly responsive depressive disorder: randomised controlled trial. Br. J. Psychiatry. 180, 411-415. https://doi.org/10.1192/bjp.180.5.411
  48. McDowell, I. 2001. Alzheimer's disease: Insights from epidemology. Aging 13, 143-162.
  49. Morgan, W. P. and P. J. O'Connor. 1987. Exercise and mental health. In Dishman, R. K. (ed.) Exercise Adherence (91-121). Champaign, III.: Human Kinetics.
  50. Nalin, A. S. and A. F. Maria. 2000. Exercise and depression in the older adult. Nutr. Clin. Care 3, 197-208. https://doi.org/10.1046/j.1523-5408.2000.00052.x
  51. Netz, Y. and T. Jacob. 1994. Exercise and the psychological state of institutionalized elderly: A review. Percept. Mot. Skills 79, 1107-1118. https://doi.org/10.2466/pms.1994.79.3.1107
  52. Oh, M. H., P. J. Houghton, W. K. Whang, and J. H. Cho. 2004. Screening of Korean herbal medicines used to improve cognitive function for anti-cholinesterase activity. Phytomedicine 11, 544-548. https://doi.org/10.1016/j.phymed.2004.03.001
  53. Palleschi, L., F. Vetta, E, De Gennaro, G. Idone, G. Sottosanti, W. Gianni, and V. Marigliano. 1996. Effect of aerobic training on the cognitive performance of elderly patients with senile dementia of alzheimer type. Arch. Gerontol. Geriatr. 22, 47-50. https://doi.org/10.1016/0167-4943(96)86912-3
  54. Korantzopoulos, P., K. P. Letsas, Z. Christogiannis, K. Kalantzi, I. Massis, H. J. Milionis, C. Pappas, and J. A. Goudevenos. Exercise-induced repolarization changes in patients with stable coronary artery disease. Am. J. Cardiol. 107, 37-40.
  55. Parker, L. N., J. Sack, D. A. Fisher, and W. D. Odell. 1978. The adrenarche: prolactin, gonadotrpins, adrenal androgens and cortisol. J. Clin. Endocrinol. Metab. 46, 396-401. https://doi.org/10.1210/jcem-46-3-396
  56. Peter, R. 2007. Ageing and the brain. Postgrad. Med. J. 82, 84-88.
  57. Pollock, M. L. and J. H. Wilmore. 1999. Exercise in Health and Disease: Evaluation and Prescription for Prevention and Rehabilitation. 3rd eds. W. B. Saunders Company. Philadelphia.
  58. Prince, J. A., H. Zetterberg, N. Andreasen, J. Marcusson, and K. Blennow. 2004. APOE epsilon 4 allele is associated with reduced cerebrospinal fluid levels of a beta 42. Neurology 63, 2116-2118.
  59. Schulz, V. 2003. Ginkgo extract or cholinesterase inhibitors in patients with dementia: What clinical trials and guidelines fail to consider. Phytomedicine 10, 74-79. https://doi.org/10.1078/1433-187X-00302
  60. Shubair, M. M., J. Kodis, R. S. Mckelvie, H. M. Arthur, and A. M. Sharma. 2004. Metabolic profile and exercise capacity outcomes. Their relationship to overweight and obesity in a canadian cardiac rehabilitation setting. J. Cardiopul. Rehabil. 24, 405-413. https://doi.org/10.1097/00008483-200411000-00008
  61. Stewart, K. J., A. C. Bacher, P. S. Hees, M. Tayback, P. Ouyang, and S. Jan de Beur. 2005. Exercise effects on bone mineral density relationships to changes in fitness and fatness. Am. J. Prev. Med. 28, 453-460. https://doi.org/10.1016/j.amepre.2005.02.003
  62. Superko, H. R. 1991. Exercise training, serum lipids, and lipoprotein particles: Is there a change threshold. Med. Sci. Sports Exerc. 23, 677-685.
  63. Van Pelt, R. E., E. M. Evans, K. B. Schechtman, A. A. Ehsani, and W. M. Kohrt. 2002. Contribitions of total and regional fat mass to risk for cardiovascular disease in older women. Am. J. Physiol. Endocrinol. Metab. 282, E1023-1028.
  64. Verdile, G., S. Fuller, C. S. Atwood, S. M. Laws, S. E. Gandy, and R. N. Martins. 2004. The role of beta amyloid in Alzheimer's disease: still a cause of everything or the only one who got caught? Pharmacol. Res. 50, 397-409. https://doi.org/10.1016/j.phrs.2003.12.028
  65. Visser, M., S. B. Kritchevsky, B. H. Goodpaster, A. B. Newman, M. Nevitt, E. Stamm, and T. B. Harris. 2002. Leg muscle mass and compHaition in relation to lower extremity performance in men and women agnd 70 to 79: the health, aging and body composition study. J. Am. Geriatr. Soc. 50, 897-904. https://doi.org/10.1046/j.1532-5415.2002.50217.x
  66. Whitmer, R. A., D. R. Gustafson, E. Barrett-Connor, M. N. Haan, E. P. Gunderson, and K. Yaffe. 2008. Central obesity and increased risk of dementia more than three decades later. Neurology 71, 1057-1064. https://doi.org/10.1212/01.wnl.0000306313.89165.ef
  67. William, R. M. 1997. Oxidative stress hypothesis in Alzhemier's disease. Free Radic. Biol. Med. 23, 134-147. https://doi.org/10.1016/S0891-5849(96)00629-6
  68. Wilson, R. S., C. F. Mendes de Leon, L. L. Barnes, J. A. Schneider, J. L. Bienias, D. A. Evans, and D. A. Bennett. 2002. Participation in cognitively stimulating activities and risk of incident Alzheimer disease. JAMA 287, 742-748. https://doi.org/10.1001/jama.287.6.742
  69. Yeun, S. W. 1993. Alzheimer type dementia and aerobic exercise. Sports Sci. 43, 29-32.
  70. Zieman, S. J., V. Melenovsky, and D. A. Kass. 2005. Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler. Thromb. Vasc. Biol. 25, 932-943. https://doi.org/10.1161/01.ATV.0000160548.78317.29

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