Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of Cinnamomi Cortex on Hypercholesterolemia Induced by Estradiol Valerate in Rats

육계(肉桂)가 Estradiol valerate에 의하여 유발된 고콜레스테롤 혈증에 미치는 영향

  • Choi, Eu-Gene (School of Korean Medicine, Pusan National University) ;
  • Kim, Hyung-Woo (School of Korean Medicine, Pusan National University) ;
  • Chung, Hee-Jin (School of Korean Medicine, Pusan National University) ;
  • Joung, Young-Min (School of Korean Medicine, Pusan National University) ;
  • Shin, Dong-Sung (School of Korean Medicine, Pusan National University) ;
  • Cho, Su-In (School of Korean Medicine, Pusan National University)
  • 최유진 (부산대학교 한의학전문대학원) ;
  • 김형우 (부산대학교 한의학전문대학원) ;
  • 정희진 (부산대학교 한의학전문대학원) ;
  • 정영민 (부산대학교 한의학전문대학원) ;
  • 신동선 (부산대학교 한의학전문대학원) ;
  • 조수인 (부산대학교 한의학전문대학원)
  • Received : 2011.01.19
  • Accepted : 2011.04.05
  • Published : 2011.04.25
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Abstract

This study was designed to investigate the effects of Cinnamomi Cortex extract (CC) on hypercholesterolemia induced by Estradiol valerate (EV) in female rats. We investigated the effects of CC on Changes in body weights for 5 weeks. In addition, we examined the effects on fasting blood glucose (FBS) and tested oral glucose tolerance test after oral administration of CC for 5 weeks. We also investigated the effects on levels of total cholesterol, HDL-cholesterol and LDL-cholesterol in serum. Treatment with CC restored weight gain rates suppressed by EV significantly. CC did not affect serum glucose level and glucose tolerance. Levels of total cholesterol and triglyceride were lowered by administration of CC compared to EV treated control respectively. These result suggest that CC can lower serum cholesterol level then prevent weight loss induced by EV. We also suggest the possibility as anti-hyperlipidemic agent of CC.

Keywords

References

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