The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Clinical Trial to Evaluate the Efficacy of Extract of Citri Pericarpium on Serum Lipid Profiles in Subjects: a Randomized, Double-blind

혈중지질에 대한 진피추출물의 유효성 평가를 위한 인체적용시험 : 무작위배정, 이중맹검

  • Lee, Jin-Sang (Oriental Medicine Industry Support Center, Daegu Technopark) ;
  • Do, Eun-Ju (Oriental Medicine Industry Support Center, Daegu Technopark) ;
  • Kwak, Min-A (Department of internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Park, Hyun-Jin (Oriental Medicine Industry Support Center, Daegu Technopark) ;
  • Ha, Il-Do (Jeahan Oriental Medical Academy, Daegu Haany University) ;
  • Sung, Ki-Jun (Foodwell Co. Ltd) ;
  • Kim, Mi-Ryeo (Oriental Medicine Industry Support Center, Daegu Technopark)
  • 이진상 ((재)대구테크노파크 한방산업지원센터) ;
  • 도은주 ((재)대구테크노파크 한방산업지원센터) ;
  • 곽민아 (대구한의대학교 한의과대학 내과학교실) ;
  • 박현진 ((재)대구테크노파크 한방산업지원센터) ;
  • 하일도 (대구한의대학교 제한동의학술원) ;
  • 성기준 ((주)푸드웰) ;
  • 김미려 ((재)대구테크노파크 한방산업지원센터)
  • Received : 2011.02.17
  • Accepted : 2011.03.10
  • Published : 2011.03.30
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Abstract

Objectives : This study was performed to evaluate the efficacy of extract from Citri Pericarpium (CP) on lipid-lowering effect in semi-healthy subjects with increased serum levels of total cholesterol and triglyceride. Methods : A experimental group (n=45) and placebo group (n=46) were randomly established based on the plasma lipid profiles (triglyceride, total cholesterol etc.) in the semi-healthy subjects, then all subjects randomly took experimental or placebo capsules, which contain 1,200 mg of CP or the same dose of soluble starch per day with regular meals for 8 weeks by double-blind method. Results : One-hundred forty (140) subjects were screened, then 91 subjects enrolled in the study. No serious adverse events were reported for trial period. The CP treatment showed statistically significant decrease in serum levels of triglyceride both at 4-weeks (p<0.01) and at 8-weeks (p=0.0001). Futhermore, there was significant difference in the triglyceride levels between CP-treated and placebo group. The CP-treated but not placebo group, experienced decrease in serum levels of total cholesterol at 8-weeks. Then there was no significant difference in the total cholesterol levels between the two groups. In addition, statistically significant difference of AST, ALT, ${\gamma}$-GT serum levels wasn't shown before and after trial in two groups. Conclusion : These results demonstrate that CP can significantly suppress the elevated triglyceride but not total cholesterol level. Therefore, CP may play a role in the improvement of blood lipid levels, as an effective functional food.

Keywords

References

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