Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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A Cytotoxic Monoterpene-Neolignan from the Stem Bark of Magnolia officinalis

  • Youn, Ui-Joung (College of Pharmacy, Chungnam National University) ;
  • Lee, Ik-Soo (College of Pharmacy, Chungnam National University) ;
  • Chen, Quan Cheng (College of Pharmacy, Chungnam National University) ;
  • Na, Min-Kyun (College of Pharmacy, Yeungnam University) ;
  • Jung, Hyun-Ju (Department of Oriental Pharmacy, Wonkwang University) ;
  • Lee, Sang-Myung (KT&G Central Research Institute) ;
  • Choi, Jae-Sue (Faculty of Food Sciences and Biotechnology. Pukyoung National University) ;
  • Woo, Mi-Hee (College of Pharmacy, Catholic University of Daegu) ;
  • Bae, Ki-Hwan (College of Pharmacy, Chungnam National University) ;
  • Min, Byung-Sun (College of Pharmacy, Catholic University of Daegu)
  • Received : 2011.02.28
  • Accepted : 2011.04.19
  • Published : 2011.06.30
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Abstract

A monoterpene-neolignan, piperitylmagnolol (1), was isolated from the stem bark of Magnolia officinalis, together with syringaresinol (2), caffeic acid (3), and sinapaldehyde (4). The isolated compounds were established on the basis of spectroscopic and physicochemical analyses including 1D- and 2D-NMR techniques, as well as on comparing the spectral data with those in the literature and of authentic samples. Compounds 1 - 4 were tested for their cytotoxic activity against the HeLa, K562, A549, and HCT116 cancer cell lines in vitro. Of the isolates, piperitylmagnolol (1) exhibited cytotoxic activity against the tested cancer cell lines with $IC_{50}$ values of 7.7 - 9.5 ${\mu}g/ml$.

Keywords

References

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