Antibacterial Activity against Pathogens of Acne and Tyrosinase Inhibitory Activity of Extract and Fractions from Bark of Prunus sargentii

산벚나무 수피 추출물 및 용매 분획물의 여드름 원인균에 대한 항균활성과 Tyrosinase 저해 활성

  • Lee, Kyoung-In (Biotechnology Industrialization Center, Dongshin University) ;
  • Yang, Sun-Ah (Dept. of Oriental Medicine Materials, Dongshin University) ;
  • Pyo, Byoung-Sik (Dept. of Oriental Medicine Materials, Dongshin University) ;
  • Kim, Sun-Min (Dept. of Oriental Medicine Materials, Dongshin University)
  • 이경인 (동신대학교 생물자원산업화지원센터) ;
  • 양선아 (동신대학교 한약재산업학과) ;
  • 표병식 (동신대학교 한약재산업학과) ;
  • 김선민 (동신대학교 한약재산업학과)
  • Received : 2011.02.21
  • Accepted : 2011.05.23
  • Published : 2011.06.30

Abstract

In this study, we investigated on antioxidative activity, antibacterial activity against pathogens of acne and tyrosinase inhibitory activity in 75% EtOH extract and its fractions from bark of Prunus sargen tii. The total polyphenol and flavonoidcontent of the EtOAc fraction were found to be 378.0 mg/g and 67.5 mg/g as the highest content. In the measurement of DPPH radical scavenging ability, EtOAc and BuOH fraction were exhibited stronger scavenging ability than the other fractions and 75% EtOH extract. In antibacterial activity by disc diffusion assay against pathogen of acne, antibacterial activity of the EtOAc fraction and 75% EtOH extract was stronger than the other fractions. Especially, the EtOAc fraction was the highest effective fraction in the antibacterial activity. Moreover, tyrosinase inhibitory activity of EtOAc fraction, BuOH fraction and 75% EtOH extract was higher than the other fractions. In particular, tyrosinase inhibitory activity of the EtOAc fraction showed higher activity than ascorbic acid used as positive control.

Keywords

References

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