YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

New Organoselenium Compounds; Synthesis of Potential Anticancer Alkylselenoallylthiopyridazine Derivatives

새로운 유기셀레늄 화합물: 잠재적 항암효과가 있는 알킬셀레노알릴티오피리다진 유도체의 합성

  • 이선희 (덕성여자대학교 약학대학) ;
  • 박명숙 (덕성여자대학교 약학대학)
  • Received : 2010.11.01
  • Accepted : 2010.12.11
  • Published : 2011.02.28
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Abstract

A series of new alkylselenoallylthiopyridazine 12~18 was synthesized as expected to retain anticancer activity. Synthetic route for the final compounds 12~18 was proceeded with diselenylation, hydrolysis/alkylation and allylthiolation from 3,6-dichloropyridazine 1. Dichloropyridazinyl diselenide 2 was prepared from the diselenide anion using synthetic route of Bhasin. Diselenide 2 can be reduced to 3-chloropyridazinyl selenolate anion using hydrazine hydrate at rt in the presence of NaOH in THF. The anion thus formed reacts readily with alkyl halide to give the 3-alkylseleno-6-chloropyridazine 3~11. 3-Alkylseleno-6-allylthiopyridazines 12~18 were prepared from 3~11 with allylmercaptan and sodium methoxide.

Keywords

References

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