Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Antihyperlipidemic and Antioxidant Effects of the Mixture of Ginseng Radix and Crataegi Fructus: Experimental Study and Preliminary Clinical Results

  • Ko, Chang-Nam (Department of Cardiovascular & Neurologic Diseases, Kyung Hee University College of Oriental Medicine) ;
  • Park, Seong-Uk (Department of Cardiovascular & Neurologic Diseases, Kyung Hee University College of Oriental Medicine) ;
  • Chang, Gyu-Tae (Department of Oriental Pediatrics, Kyung Hee University College of Oriental Medicine) ;
  • Jung, Woo-Sang (Department of Cardiovascular & Neurologic Diseases, Kyung Hee University College of Oriental Medicine) ;
  • Moon, Sang-Kwan (Department of Cardiovascular & Neurologic Diseases, Kyung Hee University College of Oriental Medicine) ;
  • Park, Jung-Mi (Department of Cardiovascular & Neurologic Diseases, Kyung Hee University College of Oriental Medicine) ;
  • Cho, Ki-Ho (Department of Cardiovascular & Neurologic Diseases, Kyung Hee University College of Oriental Medicine)
  • Received : 2011.10.29
  • Accepted : 2011.04.14
  • Published : 2011.06.29
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Abstract

The mixture of Ginseng Radix and Crataegi Fructus (Gen-CF) was developed to increase the pharmacological effect of ginseng in the treatment of hypercholesterolemia and prevention of cardiovascular disease. This study evaluated the effects of Gen-CF on serum lipids of hypercholesterolemic rats in vivo, as well as its antioxidant activities in vitro, and explored its clinical effects on patients with hypercholesterolemia. In vitro, Gen-CF displayed 1,1-diphenyl-2-picrylhydrasyl and superoxide radical scavenging activities, and inhibited hemolysis induced by 2,2'-azobis-2-amidinopropane dihydrochloride in a dose-dependent manner. In vivo, Gen-CF significantly inhibited the increases of total cholesterol, low-density lipoprotein cholesterol and triglyceride in high cholesterol-diet and Triton WR-1339 models. It also significantly inhibited the decrease of high-density lipoprotein cholesterol in these models. In the clinical trial, Gen-CF significantly lowered total cholesterol, low-density lipoprotein cholesterol, triglyceride, total lipid and phospholipid, with no adverse events, including hepatic or renal toxicity. The data suggest that Gen-CF has the potential to treat hypercholesterolemia and prevent cardiovascular disease.

Keywords

References

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