농업과학연구 (Korean Journal of Agricultural Science)

  • 제38권4호
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  • Pages.717-722
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  • 2011
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  • 2466-2402(pISSN)
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  • 2466-2410(eISSN)
충남대학교 농업과학연구소 (Institute of Agricultural Science, CNU)
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Hesperidin과 hesperetin의 cellular system에서의 항산화 효과

Antioxidative effects of hesperidin and hesperetin under cellular system

  • 조은주 (부산대학교 식품영양학과 및 노인생활환경연구소) ;
  • 이여 (부산대학교 식품영양학과 및 노인생활환경연구소) ;
  • ;
  • 김현영 (경남과학기술대학교 식품과학부)
  • Cho, Eun-Ju (Department of Food Science and Nutrition & Research Institute of Ecology for the Elderly, Pusan National University) ;
  • Li, Li (Department of Food Science and Nutrition & Research Institute of Ecology for the Elderly, Pusan National University) ;
  • Yamabe, Noriko (Institute of Natural Medicine, University of Toyama) ;
  • Kim, Hyun-Young (Department of Food Science, Gyeongnam National University of science and technology)
  • 투고 : 2011.11.03
  • 심사 : 2011.12.18
  • 발행 : 2011.12.31
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초록

In this study, we investigated the antioxidant activity of hesperidin and hesperetin, which are the active compounds from Citrus junos, in the cellular system. Under cellular model of oxidative damage using LLC-$PK_1$ renal epithelial cell, the oxidative damage induced by 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH) led to the loss of cell viability, while treatment of hesperidin and hesperetin increased significantly the cell viability as dose-dependent manner. In addition, NO-induced cellular oxidative damage by sodium nitroprusside were significantly recovered by the treatment of hesperidin and hesperetin, showing the increase of cell viability. But hesperidin and hesperetin showed no significant protective effect on $O_2{^-}$-induced cellular oxidative damage. The present study indicates that hesperidin and hesperetin protect against free radical, especially AAPH-induced peroxyl radical. In particular, hesperetin has stronger protective effect against oxidative stress than hesperidin.

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