The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Case Series of Advanced Non-Small Cell Lung Cancer Patients Treated with Hang-Am Plus

진행성 비소세포성 폐암환자에 대한 항암플러스의 치료효능 : 연속증례보고

  • Zheng, Hong-Mei (East-West Cancer Center, Dunsan Oriental Hospital, Dae-Jeon University) ;
  • Yoon, Jeung-Won (East-West Cancer Center, Dunsan Oriental Hospital, Dae-Jeon University) ;
  • Lee, Yeon-Weol (East-West Cancer Center, Dunsan Oriental Hospital, Dae-Jeon University) ;
  • Cho, Chong-Kwan (East-West Cancer Center, Dunsan Oriental Hospital, Dae-Jeon University) ;
  • Oh, Dal-Seok (Tumor Research Center, Korea Institute of Oriental Medicine) ;
  • Yoo, Hwa-Seung (East-West Cancer Center, Dunsan Oriental Hospital, Dae-Jeon University)
  • 정홍매 (대전대학교 둔산한방병원 동서암센터) ;
  • 윤정원 (대전대학교 둔산한방병원 동서암센터) ;
  • 이연월 (대전대학교 둔산한방병원 동서암센터) ;
  • 조종관 (대전대학교 둔산한방병원 동서암센터) ;
  • 오달석 (한국 한의학연구원 종양연구센터) ;
  • 유화승 (대전대학교 둔산한방병원 동서암센터)
  • Published : 2011.03.30
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Abstract

Objectives : A case series was conducted to investigate the therapeutic effects of Hang-Am Plus (HAP) on the tumor response and HRQoL (Health Related Quality of Life) in advanced non-small cell lung cancer (NSCLC) patients. Methods : Three patients were given 1,000-2,000 mg of HAP, three times a day (daily total dosage of 3,000-6,000 mg/day) for 12 weeks. Results : After the 3 month administration with HAP, three patients showed stable disease (SD) condition according to the chest computed tomography (CT), and two of the patients reported a decrease in pain levels. Conclusions : The observed NSCLC cases suggest treatment with HAP may be related to the observed tumor growth inhibition and pain reduction.

Keywords

References

  1. Available from: http://www.cancer.go.kr/cms/statics/incidence/index.html. 국가암정보센터 암발생률, 암종별 발생 현황
  2. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin. 2010;60(5):277-300. https://doi.org/10.3322/caac.20073
  3. Hayat MJ, Howlader N, Reichman ME, Edwards BK. Cancer statistics, trends, and multiple primary cancer analyses from the Surveillance, Epidemiology, and End Results (SEER) Program. Oncologist. 2007;12:20-37. https://doi.org/10.1634/theoncologist.12-1-20
  4. Asamura H, Goya T, Koshiishi Y, Sohara Y, Tsuchiya R, Miyaoka E. How should the TNM staging system for lung cancer be revised? A simulation based on the Japanese Lung Cancer Registry populations. J Thorac Cardiovasc Surg. 2006;132:316-9. https://doi.org/10.1016/j.jtcvs.2006.03.048
  5. Herbst RS, Heymach JV, Lippman SM. Lung cancer. N Engl J Med. 2008;359(13):1367-80. https://doi.org/10.1056/NEJMra0802714
  6. Schiller JH, Harrington D, Belani CP, Langer C, Sandler A, Krook J, et al.: Eastern Cooperative Oncology Group. Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med. 2002;346(2):92-8. https://doi.org/10.1056/NEJMoa011954
  7. 查名宝, 武翔, 胡琴, 陈祥. 参麦注射液合并化療治療非小细胞性肺癌的臨床觀察. ANHUI MEDICAL AND PHARMACEUTICAL JOURNAL. 2006;10(6):724-8.
  8. Yoo SH, Yoo HS, Cho CK, Lee YW. A Case Report for Recurred Squamous Cell Lung Carcinoma Treated with Hang-Am-Dan: 7 years follow-up. Korean J. Orient. Int. Med. 2007;28(2):386-90.
  9. Yanf YW, Bian HM, Jiang FR. Lung Cancer and Traditional Chinese Medicine Therapy. CHINESE ARCHIVES OF TRADITIONAL CHINESE MEDICINE. 2009;27(9):1934-6.
  10. 周雍明, 朴炳奎, 侯炜, 林洪生, 花宝金, 熊露, 等. 肺瘤平膏改善非小细胞肺癌患者免疫状态及预后的臨床觀察. Chinese Journal of Information on TCM. 2008;15(5):78-9.
  11. 賈英杰, 史福敏, 賈彦焘, 田菲, 陳軍, 孫一予. Clinical observation on advanced non-small cell carcinoma of lung treated by Xiaoyan decoction. TIANJIN JOURNAL OF TRADITIONAL CHINESE MEDICINE. 2004;21(2):108-9.
  12. Kim KS, Jung TY, Yoo HS, Lee YW, Cho CK. Case Series of Advanced Non-small Cell Lung Cancer Patients Treated with Hang-Am-Plus. Korean J. Orient. Int. Med. 2009;30(4):893-900.
  13. Meng ZQ, Shen YH, Yang PY, New-man R, Bei WY, Zhang Y, et al. Phase I study of huachansu in hepatocellular carcinoma, non-small cell lung cancer, and pancreatoc cancer: a preliminary report. CHINA ONCOLOGY. 2007;17(5):376-9.
  14. Deng J. Clinical observations of cinobufotalin combined with gefitinib for advanced non-small cell lung cancer patients. CHINESE JOURNAL OF MODERN DRUG APPLICATION. 2007;1(11):29-30.
  15. Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004;350(21):2129-39. https://doi.org/10.1056/NEJMoa040938
  16. Herbst RS, Sandler AB. Non-small cell lung cancer and antiangiogenic therapy: what can be expected of bevacizumab? Oncologist 2004;9 (Suppl 1):19-26.
  17. Gridelli C, Maione P, Del Gaizo F, Colantuoni G, Guerriero C, Ferrara C, et al. Sorafenib and Sunitinib in the Treatment of Advanced Non-Small Cell Lung Cancer. Oncologist 2007;12(2):191-200. https://doi.org/10.1634/theoncologist.12-2-191
  18. Lee DE, Lee SY, Kim JS, Cho CK, Yoo HS, Choi SJ. Antitumor effect of Hang-Am-Dan (HAD) and its ingredients on Calu6 and MCF-7 human cacner cell lines. J Kor. Oriental Med. 2009;30(5):50-60.
  19. 李大鹏. 康莱特注射液抗癌作用激励研究进展. Traditional Chinese Drug Research & Clinical Pharmacology. 2001;12(2):122-4.
  20. Park SC, Yoo HS, Park C, Cho CK, Kim GY, Kim WJ, et al. Induction of apoptosis in human lung carcinoma cells by the water extract of Panax notoginseng is associated with the activation of caspase-3 through downregulation of Akt. Int J Oncol. 2009;35(1):121-7.
  21. Park SE, Yoo HS, Jin CY, Hong SH, Lee YW, Kim BW, et al. Induction of apoptosis and inhibition of telomerase activity in human lung carcinoma cells by the water extract of Cordyceps militaris. Food Chem Toxicol. 2009;47(7):1667-75. https://doi.org/10.1016/j.fct.2009.04.014
  22. Bang JY, Kim EY, Shim TK, Yoo HS, Lee YW, Kim YS, et al. Analysis of anti-angiogenic mechanism of HangAmDan-B (HAD-B), a Korean traditional medicine, using antibody microarray chip. BioChip J. 2010;4(4):350-5. https://doi.org/10.1007/s13206-010-4412-5
  23. Lee HJ, Lee G, Yoo HS. Toxicological Study on Hang-Am-Plus in Mice. J Acupunct Meridian Stud. 2011;4(1):54-60. https://doi.org/10.1016/S2005-2901(11)60007-1