혜화의학회지 (Journal of Haehwa Medicine)

  • 제19권2호
  • /
  • Pages.85-100
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  • 2011
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  • 2586-3002(pISSN)
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  • 2586-3347(eISSN)
대전대학교 한의학연구소 (Research Institute of Korean Medicine)
권호 표지

형개련교탕가미발효방(荊芥連翹湯加味醱酵方)의 항아토피피부염 효능에 관한 실험적 연구

Experimental Research of Hyunggaeyunkyotanggamibalhyobang (HYGBH) on Atopic Dermatitis Treatment

  • Hwang, Yun-Gyu (Department of Pathology, College of Oriental Medicine, Daejeon University) ;
  • Park, Bo-Kyung (Lab of Preventive Medicine of Life, Daejeon University) ;
  • Gim, Seon-Bin (Department of Pathology, College of Oriental Medicine, Daejeon University) ;
  • Lee, Yong-Koo (Department of Internal Medicine, Hyehwa Hospital, Daejeon University) ;
  • Jin, Mi-Rim (Lab of Preventive Medicine of Life, Daejeon University) ;
  • Kim, Dong-Hee (Department of Pathology, College of Oriental Medicine, Daejeon University)
  • 투고 : 2011.01.10
  • 심사 : 2011.02.08
  • 발행 : 2011.02.20
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초록

In order to investigate the efficacy of HYGBH on atopic dermatitis, various immune related factors were studied. The results and conclusions are as follows. Atopic dermatitis symptoms were improved in HYGBH treated group and significant decrease in dermatitis index were observed in 12 and 14 weeks. HYGBH treated group showed significant decrease in CD4+, CD3+/CD69+ immune cell ratio in PBMC by 18% and 40.6% respectively. HYGBH treated group showed significant decrease in CD3+, CD11b+/Gr-1+ immune cell ratio in dorsal skin by 44.6% and 53.1% respectively. HYGBH treated group showed significant decrease in IL-4, IFN-${\gamma}$ in spleen by 29.5%, 7.7% respectively. HYGBH treated group showed decrease in the expression of IL-5, IL-13, IL-17 and histamine by 21%, 9.6%, 14%, and 32.2% respectively. Also the group showed decrease in the expression of IgE by 6.8% respectively. HYGBH treated group showed significant decrease in the transcription of IL-5 and IL-3 mRNA in skin by 35.5% and 23.2% respectively. The results above indicated that treatment of HYGBH improved atopic dermatitis symptoms by anti-oxidant activity as well as immune modulation activity as a clinical evidence. Also, to increase the application of fermented oriental medicine, different fermentation conditions using various microbial strains should be accumulated as the clinical evidence in the future.

키워드

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