Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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Evaluation of Urinary Antigen Test for Rapid Diagnosis of $Streptococcus$ $pneumoniae$ in Community-Acquired Pneumonia Patients

  • Yu, Mi-Young (Department of Laboratory Medicine, Eulji University Hospital) ;
  • Kim, In-Sik (Department of Biomedical Laboratory Science, School of Medicine, Eulji University) ;
  • Kang, Sang-Sun (Department of Biology Education, Chungbuk National University) ;
  • Cha, Beong-Hun (Department of Biomedical Laboratory Science, College of Health Sciences, Eulji University) ;
  • Hyun, Sung-Hee (Department of Biomedical Laboratory Science, School of Medicine, Eulji University)
  • Received : 2011.12.09
  • Accepted : 2011.12.31
  • Published : 2011.12.31
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Abstract

We evaluated the performance of the NOW $Streptococcus$ $pneumoniae$ urinary antigen test, standard culture and polymerase chain reaction for detecting $S.$ $pneumoniae$. The urinary antigen test of pneumonia patients represented sensitivity at 72% and specificity at 79%. The results of PCR were targeting for autolysin ($lyt$A), pneumolysin ($ply$), and spn9828. The $lyt$A sensitivity and specificity stood at 56% and 87% respectively while $ply$ sensitivity reported 83% and specificity was 47%, sensitivity and specificity of spn9828 stood at 83% and 73% respectively. The results of urinary antigen test and three genes were all statistically meaningful within $P$ <0.05. When the urinary antigen test of $S.$ $pneumoniae$ was positive, the three kinds of genes were also likely to be positive. According to the result of urinary antigen test, the results of PCR presented a meaningful difference ($P$ <0.05). Especially, the urinary antigen test of $S.$ $pneumoniae$ was likely to be positive ($P$ <0.05) when more than two genes were positive in PCR results.

Keywords

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