Diabetes affects Peripheral Nerve and Heart Function

  • Ku, Jeong-Min (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan) ;
  • Choi, Hwa-Sik (Department of Clinical Laboratory Science, Shinheung College) ;
  • Hyun, Kyung-Yae (Department of Clinical Laboratory Science, Dong Eui University) ;
  • Moon, Seong-Min (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan) ;
  • Kim, Dae-Sik (Department of Clinical Laboratory Science, Dongnam Health College) ;
  • Choi, Seok-Cheol (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan)
  • Received : 2011.10.22
  • Accepted : 2011.12.31
  • Published : 2011.12.31

Abstract

Diabetes mellitus (DM) leads to a variety of complications and thus we have retrospectively studied to investigate problems of nerve conduction velocity (NCV) study and the heart in the patients with type-II DM. Blood glucose and blood pressure levels were higher in DM group than in Non-DM group. We found that several latencies were delayed in motor conduction study of upper (median and ulnar nerve) and lower extremities (peroneal and tibial nerve), whereas amplitudes and NCVs were decreased in DM group compared with Non-DM group. Latencies of sensory conduction study in upper and lower extremities (sural nerve) were delayed, while amplitudes and NCVs were lower in DM group than in Non-DM group. Abnormal percent of the electrocardiogram was higher in DM group than in Non-DM group. This retrospective study suggests that type-II DM can cause a damage effect on the peripheral nerve and the heart function.

Keywords

References

  1. Adult Trearment Panel III. Third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults Treatment Panel III: Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report Circulation 2002. 106: 31-43. https://doi.org/10.1161/01.CIR.0000022405.68464.CA
  2. Aksnes TA, Schmieder RE, Kjeldsen SE, Ghani S, Hua TA, Julius S. Impact of new-onset diabetes mellitus on development of AF and heart failure in high-risk hypertension (from the VALUE Trial). Am J Cardiol. 2008. 101: 634-638. https://doi.org/10.1016/j.amjcard.2007.10.025
  3. American Diabetes Association. Standards of medical care in diabetes. Diabetes Care 2007. 30(suppl-1): S4-S41.
  4. Bansal V, Kalita J, Misra UK. Diabetic neuropathy. Postgrad Med J. 2006. 82: 95-100. https://doi.org/10.1136/pgmj.2005.036137
  5. Barth AS, Tomaselli GF. Cardiac Metabolism and Arrhythmias. Diabetes Care 2008. 31: 1767-1772. https://doi.org/10.2337/dc08-0433
  6. Boyd BS, Wnek L, Gray AT, Topp KS. Mechanosensitivity during lower extremity neurodynamic testing is diminished in individuals with Type 2 Diabetes Mellitus and peripheral neuropathy: a cross sectional study. BMC Neurology 2010. 10: 75-89. https://doi.org/10.1186/1471-2377-10-75
  7. Marionneau C, Aimond F, Brunet S, Niwa N, Finck B, Kelly DP, Nerbonne JM. PPARalpha-mediated remodelling of repolarizing voltage-gated K+(Kv) channels in a mouse model of metaboliccardiomyopathy. J Mol Cell Cardiol. 2008. 44: 1002-1015. https://doi.org/10.1016/j.yjmcc.2008.03.023
  8. Movahed MR, Hashemzadeh MJammal MM. Diabetes mellitus is a strong, independent risk for atrial fibrillation and flutter in addition to other cardiovascular disease. Int J Cardiol. 2005. 105: 315-318. https://doi.org/10.1016/j.ijcard.2005.02.050
  9. Nichols GA, Ephross SA, Gullion GA, Brown JR, Koro CE. The incidence of congestive heart failure in type 2 diabetes. Diabetes Care 2004. 27: 1879-1884. https://doi.org/10.2337/diacare.27.8.1879
  10. Oh SJ. Clinical electromyography: nerve conduction studies. In: Nerve conduction in polyneurophathies. Baltimore: Williams and Wilkins. 1993: 579-591.
  11. Stratton IM, Adler AI, Neil HAW, Matthews DR, Manley SE, Cull CA, Hadden D, Turner RC, Holman RR. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ. 2000. 321: 405-412. https://doi.org/10.1136/bmj.321.7258.405
  12. Strotmyer ES, de Rekeneire N, Schwartz AV, Faulkner KA, Renick H, Goodpaster BH, Shorr RI, Vinik AI, Harris TB, Newman AB. The relationship of reduced peripheral nerve function and diabetes with physical performance in older white and black adults. Diabetes Care 2008. 31: 1219-1221. https://doi.org/10.2337/dc07-1832
  13. Tesfaye S, Malik R Harris N. Arterio venous shunting and proliferating new vesells in acute painful neuropathy of rapid glycemic control (insulin neuritis). Diabetologia 1996. 39:329-335. https://doi.org/10.1007/BF00418349
  14. VanHoose L, Sawers Y, Loganathan R, Vacek JL, Stehno-Bittel L, Novikova L, AI-Jarrah M, Smirnova IV. Electrocardiographic changes with the onset of diabetes and the impact of aerobic exercise training in the Zucker Diabetic Fatty (ZDF) rat. Cardiovascular Diabetology. 2010. 9: 56-65. https://doi.org/10.1186/1475-2840-9-56
  15. Veglio M, Chinaglia A, Cavallo-Perin P. QT interval, cardiovascular risk factors and risk of death in diabetes. J Endocrinol Invest. 2004. 27: 175-181.
  16. Vinik AI, Vinik E. Prevention of the complications of diabetes. Am J Manag Care 2003. 9(3 Suppl): S63-S80.
  17. Viswanathan V, Seena R, Nair MB, Snehalatha C, Bhoopathy RM, Ramachandran A. Nerve conduction abnormalities in different stages of glucose intolerance. Neurology India 2004. 52: 466-469.
  18. Zimmet P, Alberti KG, Shaw J. Global and societal implications of the diabetes epidemic. Nature 2001. 414: 782-787. https://doi.org/10.1038/414782a