Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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A Case of Acute Eosinophilic Pneumonia after Hematopoietic Stem Cell Transplantation

혈연간 동종 조혈모세포 이식 후 이식편대숙주질환과 함께 발생한 급성 호산구성 폐렴 1예

  • Park, Hwan-Sung (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Ok, Tae-Jin (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, You-Jae (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Guang-Un (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Park, So-Eun (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • An, Ji-Hyun (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Yun-Ku (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Jeong, Jae-Ho (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Su-Jeong (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lee, Yu-Mi (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lee, Ho-Su (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kang, Bo-Hyoung (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Ga-Hee (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Dae-Young (Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Woo-Sung (Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Dong-Soon (Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Song, Jin-Woo (Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine)
  • 박환성 (울산대학교 의과대학 서울아산병원 내과학교실) ;
  • 옥태진 (울산대학교 의과대학 서울아산병원 내과학교실) ;
  • 김유재 (울산대학교 의과대학 서울아산병원 내과학교실) ;
  • 김광운 (울산대학교 의과대학 서울아산병원 내과학교실) ;
  • 박소은 (울산대학교 의과대학 서울아산병원 내과학교실) ;
  • 안지현 (울산대학교 의과대학 서울아산병원 내과학교실) ;
  • 김윤구 (울산대학교 의과대학 서울아산병원 내과학교실) ;
  • 정재호 (울산대학교 의과대학 서울아산병원 내과학교실) ;
  • 김수정 (울산대학교 의과대학 서울아산병원 내과학교실) ;
  • 이유미 (울산대학교 의과대학 서울아산병원 내과학교실) ;
  • 이호수 (울산대학교 의과대학 서울아산병원 내과학교실) ;
  • 강보형 (울산대학교 의과대학 서울아산병원 내과학교실) ;
  • 김가희 (울산대학교 의과대학 서울아산병원 내과학교실) ;
  • 김대영 (울산대학교 의과대학 서울아산병원 혈액내과학교실) ;
  • 김우성 (울산대학교 의과대학 서울아산병원 호흡기내과학교실) ;
  • 김동순 (울산대학교 의과대학 서울아산병원 호흡기내과학교실) ;
  • 송진우 (울산대학교 의과대학 서울아산병원 호흡기내과학교실)
  • Received : 2011.05.31
  • Accepted : 2011.07.22
  • Published : 2011.12.30
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Abstract

Pulmonary complications occur in 40~60% of patients who receive hematopoietic stem cell transplantation (HSCT) and are a source of substantial morbidity and mortality. Acute eosinophilic pneumonia (AEP) is an uncommon, non-infectious pulmonary complication occurring in HSCT recipients. We now report the case of a 52-year-old man with AEP who was treated with allogenic HSCT due to acute myeloid leukemia. He complained of fever, cough and dyspnea 390 days after allogenic HSCT. He also had skin and hepatic graft versus host disease (GVHD). Hypoxemia, diffuse pulmonary infiltrates on a chest x-ray and eosinophilia in bronchoalveolar lavage fluid were also noted in several tests. His symptoms, pulmonary infiltrates, hepatic dysfunction and skin lesions rapidly improved after treatment with corticosteroid therapy. Our case supports the idea that AEP is a late phase non-infectious pulmonary complication and one of the manifestations of chronic GVHD.

Keywords

References

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