Tuberculosis and Respiratory Diseases

  • 제71권6호
  • /
  • Pages.431-437
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  • 2011
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  • 1738-3536(pISSN)
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  • 2005-6184(eISSN)
대한결핵및호흡기학회 (The Korean Academy of Tuberculosis and Respiratory Diseases)
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Impulse Oscillometry (IOS)를 이용한 무기분진 노출자에서의 기도폐쇄 연구

The Application of Impulse Oscillometry (IOS) in the Workers Who had been Exposed to Inorganic Dust Induced Early Airway Obstruction

  • 이정오 (근로복지공단 직업성폐질환연구소) ;
  • 이유림 (근로복지공단 직업성폐질환연구소) ;
  • 최병순 (근로복지공단 직업성폐질환연구소) ;
  • 이홍기 (한국산업의학연구소)
  • Lee, Joung-Oh (Occupational Lung Diseases Institute, Korea Workers' Compensation & Welfare Service (KCOMWEL)) ;
  • Lee, You-Lim (Occupational Lung Diseases Institute, Korea Workers' Compensation & Welfare Service (KCOMWEL)) ;
  • Choi, Byung-Soon (Occupational Lung Diseases Institute, Korea Workers' Compensation & Welfare Service (KCOMWEL)) ;
  • Lee, Hong-Ki (Korea Occupational Medicial Institute)
  • 투고 : 2011.08.26
  • 심사 : 2011.11.03
  • 발행 : 2011.12.30
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초록

Background: We tried to examine the small airway diseases which can be found early, in workers exposed to inorganic dusts. This is measured in normal breath by using the impulse oscillometry (IOS). Methods: The Pulmonary function test (forced vital capacit [FVC], forced expiratory volume in one second [$FEV_1$], forced expiratory flow between 25% and 75% of vital capacity [$FEF_{25-75}$]), IOS resistance (Rrs at 5, 10, 15, 20, 25, 35 Hz) and reactance (Xrs at 5, 10, 15, 20, 25, 35 Hz) were measured for 454 workers. The subjects were classified into 173 workers of normal (38.1%) and 281 patients with pneumoconiosis (61.9%). Results: There were significant differences between normal and patients with FVC ($3.82{\pm}0.61$ vs. $3.53{\pm}0.56L$), $FEV_1$ ($2.67{\pm}0.63$ vs. $2.35{\pm}0.48L$), and $FEF_{25-75}$ ($1.88{\pm}0.95$ vs. $1.47{\pm}0.80L/sec$) between groups (p<0.05). And as for IOS, there was no significant difference in resistance (Rrs) (p>0.05), and there were significant differences between normal and patients with reactance (Xrs) 15 Hz ($0.003{\pm}0.05$ vs. $-0.006{\pm}0.04kPa/L/s$), 20 Hz ($0.043{\pm}0.05$ vs. $0.031{\pm}0.04kPa/L/s$), and 35 Hz ($0.141{\pm}0.05$ vs. $0.131{\pm}0.05kPa/L/s$) between groups (p<0.05). Conclusion: We could find out that 15 Hz, 20 Hz, and 35 Hz values of reactance were significantly influenced by pneumoconiosis. When usefulness and reproducibility to carry out the IOS are considered, it is thought that in future work will be required to draw the reference values for normal Korean persons.

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참고문헌

  1. Chia KS, Ng TP, Jeyaratnam J. Small airways function of silica-exposed workers. Am J Ind Med 1992;22:155-62. https://doi.org/10.1002/ajim.4700220203
  2. Begin R, Ostiguy G, Cantin A, Bergeron D. Lung function in silica-exposed workers. A relationship to disease severity assessed by CT scan. Chest 1988;94:539-45. https://doi.org/10.1378/chest.94.3.539
  3. Park IN, Hue SH. Bronchial hyperreactivity in subjects with smail airway disease using methacholine bronchial provocation test. Tuberc Respir Dis 1990;37:151-9.
  4. Kim YS, Kweon SH, Song MY, Yoo SM, Park JS, Jee YK, et al. The application of impulse oscillometry (IOS) in the detection of smoking induced early airway obstruction. Tuberc Respir Dis 1997;44:1030-9. https://doi.org/10.4046/trd.1997.44.5.1030
  5. Dubois AB, Brody AW, Lewis DH, Burgess BR Jr. Oscillation mechanics of lungs and chest in man. J Appl Physiol 1956;8:587-94. https://doi.org/10.1152/jappl.1956.8.6.587
  6. Demedts M, Van Noord JA, Van De Woestijne KP. Clinical applications of forced oscillation technique. Chest 1991;99:795-7. https://doi.org/10.1378/chest.99.4.795
  7. Oostveen E, MacLeod D, Lorino H, Farre R, Hantos Z, Desager K, et al. The forced oscillation technique in clinical practice: methodology, recommendations and future developments. Eur Respir J 2003;22:1026-41. https://doi.org/10.1183/09031936.03.00089403
  8. Wouters EF. Total respiratory impedance measurement by forced oscillations: a noninvasive method to assess bronchial response in occupational medicine. Exp Lung Res 1990;16:25-40. https://doi.org/10.3109/01902149009064697
  9. Jorna T, Koiter N, Slangen J, Henderson P, Wouters E, Borm P. Effects of inorganic dust exposure on lung function measured by spirometry and forced oscillation technique (FOT). Am Rev Respir Dis 1992;145:A539 (Abstract).
  10. Pairon JC, Iwatsubo Y, Hubert C, Lorino H, Nouaigui H, Gharbi R. Measurement of bronchial responsiveness by forced oscillation technique in occupational epidemiology. Eur Respir J 1994;7:484-9. https://doi.org/10.1183/09031936.94.07030484
  11. Pham QT, Bourgkard E, Chau N, Willim G, Megherbi SE, Teculescu D, et al. Forced oscillation technique (FOT): a new tool for epidemiology of occupational lung diseases? Eur Respir J 1995;8:1307-13. https://doi.org/10.1183/09031936.95.08081307
  12. Kim JS, Kim CW, Park JY, Chung HW, Park JW, Hong CS. Clinical usefulness of impulse oscillometry (IOS) in bronchial asthma. Korean J Med 2000;59:522-8.
  13. Park JY, Kim CW, Lee JH, Park YS, Park BG, Park JW, et al. Usefulness of impulse oscillometry in patients with asymptomatic bronchial asthma. J Asthma Allergy Clin Immunol 2001;21:491-9.
  14. Hayes DA, Pimmel RL, Fullton JM, Bromberg PA. Detection of respiratory mechanical dysfunction by forced random noise impedance parameters. Am Rev Respir Dis 1979;120:1095-100.
  15. Landser FJ, Nagles J, Demedts M, Billiet L, van de Woestijne KP. A new method to determine frequency characteristics of the respiratory system. J Appl Physiol 1976;41:101-6. https://doi.org/10.1152/jappl.1976.41.1.101
  16. Peslin R, Duvivier C, Gallina C, Cervantes P. Upper airway artifact in respiratory impedance measurements. Am Rev Respir Dis 1985;132:712-4.
  17. Choi BS, Kim JH, Lee JO, Shin JH. Logical propulsion plan research of pneumoconiosis worker protection business by pneumoconiosis worker graying back. Gwacheon: Ministry of Labor; 2006.
  18. Wright JL, Harrison N, Wiggs B, Churg A. Quartz but not iron oxide causes air-flow obstruction, emphysema, and small airways lesions in the rat. Am Rev Respir Dis 1988;138:129-35. https://doi.org/10.1164/ajrccm/138.1.129
  19. Churg A, Hobson J, Wright J. Functional and morphologic comparison of silica- and elastase-induced airflow obstruction. Exp Lung Res 1989;15:813-22. https://doi.org/10.3109/01902148909069628
  20. Choi BS. A study on the development of coalworkers' pneumoconiosis in Korea. Seoul: Graduate School of Health, Seoul National University; 1995.
  21. van Noord JA, Wellens W, Clarysse I, Cauberghs M, Van de Woestijne KP, Demedts M. Total respiratory resistance and reactance in patients with upper airway obstruction. Chest 1987;92:475-80. https://doi.org/10.1378/chest.92.3.475
  22. Severinghaus JW. Blood gas calculator. J Appl Physiol 1966;21:1108-16. https://doi.org/10.1152/jappl.1966.21.3.1108
  23. Peslin R, Marchal F, Duvivier C, Ying Y, Gallina C. Evaluation of a modified head generator for respiratory impedance measurements. Eur Respir Rev 1991;1:140-5.
  24. Park JS, Kim YS, Choi EK, Jee YK, Lee KY, Kim KY, et al. Effect of exercise on pulmonary function. Tuberc Respir Dis 1998;45:351-9. https://doi.org/10.4046/trd.1998.45.2.351
  25. Keman S, Willemse B, Wesseling GJ, Kusters E, Borm PJ. A five year follow-up of lung function among chemical workers using flow-volume and impedance measurements. Eur Respir J 1996;9:2109-15. https://doi.org/10.1183/09031936.96.09102109