Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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The Clinical Outcomes of Photodynamic Therapy in Early Lung Cancer Patients

조기 폐암환자에서 광역동치료의 효과

  • Lee, Young-Seok (Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Oh, Yeon-Mok (Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Shim, Tae-Sun (Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Woo-Sung (Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • An, Jung-Sun (Division of Pulmonary, Allergy and Critical Care Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Choi, Chang-Min (Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Jang, Seung-Hun (Division of Pulmonary, Allergy and Critical Care Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine)
  • 이영석 (울산대학교 의과대학 서울아산병원 호흡기내과학교실) ;
  • 오연목 (울산대학교 의과대학 서울아산병원 호흡기내과학교실) ;
  • 심태선 (울산대학교 의과대학 서울아산병원 호흡기내과학교실) ;
  • 김우성 (울산대학교 의과대학 서울아산병원 호흡기내과학교실) ;
  • 안정선 (한림대학교 의과대학 한림대성심병원 호흡기내과학교실) ;
  • 최창민 (울산대학교 의과대학 서울아산병원 호흡기내과학교실) ;
  • 장승훈 (한림대학교 의과대학 한림대성심병원 호흡기내과학교실)
  • Received : 2011.07.19
  • Accepted : 2011.09.01
  • Published : 2011.10.30
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Abstract

Background: Photodynamic therapy (PDT) is effective in managing small superficial early lung cancer patients who were deemed nonsurgical candidates. However, we do not have any previous report on the usefulness of PDT in early lung cancer in South Korea. Thus we report here our experience of PDT in early lung cancer patients. Methods: 10 patients who underwent PDT for managing early lung cancer between June 2006 and July 2010 were analyzed. PDT was carried out 48 hours after photosensitizer injection. Re-bronchoscopy was carried out 48 hours after PDT in order to remove a necrotic tissue from the PDT site. For evaluation of PDT response, bronchoscopy and chest computed tomography (CT) were performed after 3 months. Results: The median age of patients was 69 (49~77) and all patients were male. The smoking history of patients was 48 (20~75) pack-year and the median follow up of patients was 25 (11~52) months. Complete remission was observed in 10 patients and the recurrence of lung cancer was observed in 3 patients. Out of 10 patients, 3 patients died (one case of lung cancer progression and two cases of pneumonia). Conclusion: The PDT is a safe and effective treatment in early lung cancer patients who are not suitable for surgical resection. The PDT in clinical practice is an attractive option in the treatment of early lung cancer.

Keywords

References

  1. Welch HG, Schwartz LM, Woloshin S. Are increasing 5-year survival rates evidence of success against cancer? JAMA 2000;283:2975-8. https://doi.org/10.1001/jama.283.22.2975
  2. Kennedy TC, McWilliams A, Edell E, Sutedja T, Downie G, Yung R, et al. Bronchial intraepithelial neoplasia/early central airways lung cancer: ACCP evidencebased clinical practice guidelines (2nd edition). Chest 2007;132(3 Suppl):221S-233S. https://doi.org/10.1378/chest.07-1377
  3. Moghissi K. Role of bronchoscopic photodynamic therapy in lung cancer management. Curr Opin Pulm Med 2004;10:256-60. https://doi.org/10.1097/01.mcp.0000128434.57020.6a
  4. Maziak DE, Markman BR, MacKay JA, Evans WK; Cancer Care Ontario Practice Guidelines Initiative Lung Cancer Disease Site Group. Photodynamic therapy in nonsmall cell lung cancer: a systematic review. Ann Thorac Surg 2004;77:1484-91. https://doi.org/10.1016/j.athoracsur.2003.07.017
  5. D, Makowski M, Stoklosa T, Legat M, Issat T, Goƚab J. Direct tumor damage mechanisms of photodynamic therapy. Acta Biochim Pol 2005;52:339-52.
  6. Kim JO, Jung MK, Jung SS. Photodynamic therapy (PDT) in lung cancer. Tuberc Respir Dis 2007;62:175-83. https://doi.org/10.4046/trd.2007.62.3.175
  7. Moghissi K, Dixon K. Is bronchoscopic photodynamic therapy a therapeutic option in lung cancer? Eur Respir J 2003;22:535-41. https://doi.org/10.1183/09031936.03.00005203
  8. Yoon SH, Han KT, Kim GN, Lee SI. Effect of photodynamic therapy in lung cancer. Tuberc Respir Dis 2004;57:358-63. https://doi.org/10.4046/trd.2004.57.4.358
  9. Endo C, Miyamoto A, Sakurada A, Aikawa H, Sagawa M, Sato M, et al. Results of long-term follow-up of photodynamic therapy for roentgenographically occult bronchogenic squamous cell carcinoma. Chest 2009;136:369-75. https://doi.org/10.1378/chest.08-2237
  10. Okunaka T, Kato H, Tsutsui H, Ishizumi T, Ichinose S, Kuroiwa Y. Photodynamic therapy for peripheral lung cancer. Lung Cancer 2004;43:77-82. https://doi.org/10.1016/j.lungcan.2003.08.016
  11. Corti L, Toniolo L, Boso C, Colaut F, Fiore D, Muzzio PC, et al. Long-term survival of patients treated with photodynamic therapy for carcinoma in situ and early non-small-cell lung carcinoma. Lasers Surg Med 2007;39:394-402. https://doi.org/10.1002/lsm.20513
  12. Furukawa K, Kato H, Konaka C, Okunaka T, Usuda J, Ebihara Y. Locally recurrent central-type early stage lung cancer <1.0 cm in diameter after complete remission by photodynamic therapy. Chest 2005;128:3269-75. https://doi.org/10.1378/chest.128.5.3269
  13. Mathur PN, Edell E, Sutedja T, Vergnon JM; American College of Chest Physicians. Treatment of early stage non-small cell lung cancer. Chest 2003;123(1 Suppl):176S-180S. https://doi.org/10.1378/chest.123.1_suppl.176S
  14. Moghissi K, Dixon K, Thorpe JA, Stringer M, Oxtoby C. Photodynamic therapy (PDT) in early central lung cancer: a treatment option for patients ineligible for surgical resection. Thorax 2007;62:391-5. https://doi.org/10.1136/thx.2006.061143
  15. Usuda J, Kato H, Okunaka T, Furukawa K, Tsutsui H, Yamada K, et al. Photodynamic therapy (PDT) for lung cancers. J Thorac Oncol 2006;1:489-93. https://doi.org/10.1097/01243894-200606000-00018
  16. Nakamura H, Kawasaki N, Hagiwara M, Ogata A, Kato H. Endoscopic evaluation of centrally located early squamous cell carcinoma of the lung. Cancer 2001;91:1142-7. https://doi.org/10.1002/1097-0142(20010315)91:6<1142::AID-CNCR1110>3.0.CO;2-K
  17. Miyazu Y, Miyazawa T, Kurimoto N, Iwamoto Y, Kanoh K, Kohno N. Endobronchial ultrasonography in the assessment of centrally located early-stage lung cancer before photodynamic therapy. Am J Respir Crit Care Med 2002;165:832-7. https://doi.org/10.1164/ajrccm.165.6.2108092
  18. Kato H, Okunaka T, Tsuchida T, Shibuya H, Fujino S, Ogawa K. Analysis of the cost-effectiveness of photodynamic therapy in early stage lung cancer. Diagn Ther Endosc 1999;6:9-16. https://doi.org/10.1155/DTE.6.9
  19. Carey FA, Donnelly SC, Walker WS, Cameron EW, Lamb D. Synchronous primary lung cancers: prevalence in surgical material and clinical implications. Thorax 1993;48:344-6. https://doi.org/10.1136/thx.48.4.344
  20. Ferguson MK, DeMeester TR, DesLauriers J, Little AG, Piraux M, Golomb H. Diagnosis and management of synchronous lung cancers. J Thorac Cardiovasc Surg 1985;89:378-85.
  21. Wu SC, Lin ZQ, Xu CW, Koo KS, Huang OL, Xie DQ. Multiple primary lung cancers. Chest 1987;92:892-6. https://doi.org/10.1378/chest.92.5.892
  22. Jung EJ, Lee JH, Jeon K, Koh WJ, Suh GY, Chung MP, et al. Treatment outcomes for patients with synchronous multiple primary non-small cell lung cancer. Lung Cancer 2011;73:237-42. https://doi.org/10.1016/j.lungcan.2010.11.008
  23. National Cancer Information Center (NCIC). Cancer incidence rate 2008. Goyang: ICIC; c2010 [cited 2011 Sep 30]. Available from: http://www.cancer.go.kr/ncic/cics_f/01/011/index.html.
  24. Johnson BE. Second lung cancers in patients after treatment for an initial lung cancer. J Natl Cancer Inst 1998;90:1335-45. https://doi.org/10.1093/jnci/90.18.1335
  25. Johnson BE, Cortazar P, Chute JP. Second lung cancers in patients successfully treated for lung cancer. Semin Oncol 1997;24:492-9.
  26. Moghissi K, Dixon K. Photodynamic therapy for synchronous occult bronchial cancer 17 years after pneumonectomy. Interact Cardiovasc Thorac Surg 2005;4:327-8.
  27. Usuda J, Ichinose S, Ishizumi T, Hayashi H, Ohtani K, Maehara S, et al. Management of multiple primary lung cancer in patients with centrally located early cancer lesions. J Thorac Oncol 2010;5:62-8. https://doi.org/10.1097/JTO.0b013e3181c42287

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