Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
권호 표지
DOI QR코드

DOI QR Code

Pattern Analysis of $^{67}Gallium$ Scintigraphy in Sarcoidosis

유육종증의 $^{67}Gallium$ 스캔 유형 분석

  • Kang, Yun-Hee (Department of Nuclear Medicine, Eulji University School of Medicine) ;
  • Lim, Seok-Tae (Department of Nuclear Medicine, Chonbuk National University Medical School) ;
  • Moon, Eun-Ha (Department of Nuclear Medicine, Chonbuk National University Medical School) ;
  • Kim, Dong-Wook (Department of Nuclear Medicine, Chonbuk National University Medical School) ;
  • Jeong, Hwan-Jeong (Department of Nuclear Medicine, Chonbuk National University Medical School) ;
  • Sohn, Myung-Hee (Department of Nuclear Medicine, Chonbuk National University Medical School)
  • 강윤희 (을지대학교 의과대학 핵의학교실) ;
  • 임석태 (전북대학교 의학전문대학원 핵의학교실) ;
  • 문은하 (전북대학교 의학전문대학원 핵의학교실) ;
  • 김동욱 (전북대학교 의학전문대학원 핵의학교실) ;
  • 정환정 (전북대학교 의학전문대학원 핵의학교실) ;
  • 손명희 (전북대학교 의학전문대학원 핵의학교실)
  • Received : 2011.02.14
  • Accepted : 2011.05.20
  • Published : 2011.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Background: $^{67}Ga$ scintigraphy has been used for years in sarcoidosis for diagnosis and to determine the extent of the disease. The present report is a study of various findings of $^{67}Ga$ scintigraphy in patients with sarcoidosis. Methods: Between 1998 and 2007, 16 patients (male：female, 6:10; age, $35.9{\pm}15.3$ years) with histologically proven sarcoidosis underwent clinical evaluation and $^{67}Ga$ scintigraphy. According to the site of involvement, they were divided into subtypes and analyzed. Results: Sixteen patients with sarcoidosis had involvement of various organs, including lymph nodes (13/16, 81.3%), lung (3/16, 18.8%), muscle (1/16, 6.3%), subcutaneous tissue (1/16, 6.3%), glands (1/16, 6.3%), and bone (1/16, 6.3%). Sites of involved lymph nodes were thorax (12/13, 92.3%), supraclavicular area (5/13, 38.5%), inguinal area (2/13, 15.4%), abdomen (2/13, 15.4%), and pelvis (1/13, 7.7%). Conclusion: Because sarcoidosis frequently involves multiple organs, $^{67}Ga$ scintigraphy is a useful method in for evaluating the whole body. Nuclear medicine physicians should be familiar with the various findings of gallium uptake in sarcoidosis.

Keywords

References

  1. Koyama T, Ueda H, Togashi K, Umeoka S, Kataoka M, Nagai S. Radiologic manifestations of sarcoidosis in various organs. Radiographics 2004;24:87-104. https://doi.org/10.1148/rg.241035076
  2. Yi GW, Koh EM, Chung JK, Lee MC, Shim YS, Koh CS. Three cases of sarcoidosis evaluated by 67Ga scintigraphy. Korean J Nucl Med 1988;22:93-6.
  3. Sulavik SB, Spencer RP, Weed DA, Shapiro HR, Shiue ST, Castriotta RJ. Recognition of distinctive patterns of gallium-67 distribution in sarcoidosis. J Nucl Med 1990;31:1909-14.
  4. Britt AR, Francis IR, Glazer GM, Ellis JH. Sarcoidosis: abdominal manifestations at CT. Radiology 1991;178:91-4. https://doi.org/10.1148/radiology.178.1.1984330
  5. Johnson DG, Johnson SM, Harris CC, Piantadosi CA, Blinder RA, Coleman RE. Ga-67 uptake in the lung in sarcoidosis. Radiology 1984;150:551-5. https://doi.org/10.1148/radiology.150.2.6581505
  6. Gupta RG, Bekerman C, Sicilian L, Oparil S, Pinsky SM, Szidon JP. Gallium 67 citrate scanning and serum angiotensin converting enzyme levels in sarcoidosis. Radiology 1982;144:895-9. https://doi.org/10.1148/radiology.144.4.6287521
  7. Sohn HS, Kim EN. A case of muscular sarcoidosis diagnosed by Gallium-67 scintigraphy and magnetic resonance imaging. Korean J Nucl Med 1999;33:543-8.
  8. Moore SL, Teirstein AE. Musculoskeletal sarcoidosis: spectrum of appearances at MR imaging. Radiographics 2003;23:1389-99. https://doi.org/10.1148/rg.236025172
  9. Henry DA, Kiser PE, Scheer CE, Cho SR, Tisnado J. Multiple imaging evaluation of sarcoidosis. Radiographics 1986;6:75-95. https://doi.org/10.1148/radiographics.6.1.3685486
  10. Kim MJ, Yoo HS, Lee JT, Suh JH, Park CY, Lee DY. 67Ga of primary hepatocellular carcinoma: correlation with angiography. Korean J Nucl Med 1989;23:27-34.
  11. Tsan MF, Scheffel U. Mechanism of gallium-67 accumulation in tumors. J Nucl Med 1986;27:1215-9.
  12. Baughman RP, Shipley R, Eisentrout CE. Predictive value of gallium scan, angiotensin-converting enzyme level, and bronchoalveolar lavage in two-year follow-up of pulmonary sarcoidosis. Lung 1987;165:371-7. https://doi.org/10.1007/BF02714452
  13. Braun JJ, Kessler R, Constantinesco A, Imperiale A. 18F-FDG PET/CT in sarcoidosis management: review and report of 20 cases. Eur J Nucl Med Mol Imaging 2008;35:1537-43. https://doi.org/10.1007/s00259-008-0770-9
  14. Nishiyama Y, Yamamoto Y, Fukunaga K, Takinami H, Iwado Y, Satoh K, et al. Comparative evaluation of 18F-FDG PET and 67Ga scintigraphy in patients with sarcoidosis. J Nucl Med 2006;47:1571-6.