Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
권호 표지
DOI QR코드

DOI QR Code

Cutaneous Metastasis from Lung Cancer: A Single-Institution Retrospective Analysis

  • Lee, Jong-Hwan (Department of Internal Medicine, Korea Cancer Center Hospital, Korean Institute of Radiological & Medical Sciences) ;
  • Ahn, Se-Jin (Department of Internal Medicine, Korea Cancer Center Hospital, Korean Institute of Radiological & Medical Sciences) ;
  • Kim, Hyung-Jin (Department of Internal Medicine, Korea Cancer Center Hospital, Korean Institute of Radiological & Medical Sciences) ;
  • Jang, Sang-Eon (Department of Internal Medicine, Korea Cancer Center Hospital, Korean Institute of Radiological & Medical Sciences) ;
  • Noh, Geum-Youb (Department of Internal Medicine, Korea Cancer Center Hospital, Korean Institute of Radiological & Medical Sciences) ;
  • Kim, Hye-Ryoun (Department of Internal Medicine, Korea Cancer Center Hospital, Korean Institute of Radiological & Medical Sciences) ;
  • Kim, Cheol-Hyeon (Department of Internal Medicine, Korea Cancer Center Hospital, Korean Institute of Radiological & Medical Sciences) ;
  • Lee, Jae-Cheol (Department of Internal Medicine, Korea Cancer Center Hospital, Korean Institute of Radiological & Medical Sciences)
  • Received : 2010.08.17
  • Accepted : 2010.10.01
  • Published : 2011.02.28
Download PDF
⟨ Previous Next ⟩

Abstract

Background: Lung cancer is responsible for substantial proportions of cutaneous metastasis from internal malignancies. The aim of this study was to evaluate the clinical manifestations and outcomes of cutaneous metastasis in Korean lung cancer patients. Methods: On a retrospective basis, we analyzed medical records of all patients diagnosed with lung cancer from 2000 to 2006. Results: Cutaneous metastases were found in 10 of 4,385 patients. The number of cases was highest for squamous cell carcinoma. However, there was no metastasis from 754 cases of small cell carcinomas. Cutaneous metastasis was detected during staging work-up in 4 patients and it was the presenting sign of recurrence post-operative in 2 patients. Average time from the diagnosis to discovery of cutaneous metastasis was 16.3 months and median survival was 8.5 months (range, 1.8~19.1 months). Conclusion: Physicians should be acquainted with clinical manifestations and outcomes of cutaneous metastasis from lung cancer to detect new, recurrent cancer, or disease progression, and to administer appropriate and prompt management.

Keywords

References

  1. Nashan D, Muller ML, Braun-Falco M, Reichenberger S, Szeimies RM, Bruckner-Tuderman L. Cutaneous metastases of visceral tumours: a review. J Cancer Res Clin Oncol 2009;135:1-14. https://doi.org/10.1007/s00432-008-0432-0
  2. Hu SC, Chen GS, Wu CS, Chai CY, Chen WT, Lan CC. Rates of cutaneous metastases from different internal malignancies: experience from a Taiwanese medical center. J Am Acad Dermatol 2009;60:379-87. https://doi.org/10.1016/j.jaad.2008.10.007
  3. Krathen RA, Orengo IF, Rosen T. Cutaneous metastasis: a meta-analysis of data. South Med J 2003;96:164-7. https://doi.org/10.1097/01.SMJ.0000053676.73249.E5
  4. Hu SC, Chen GS, Lu YW, Wu CS, Lan CC. Cutaneous metastases from different internal malignancies: a clinical and prognostic appraisal. J Eur Acad Dermatol Venereol 2008;22:735-40. https://doi.org/10.1111/j.1468-3083.2008.02590.x
  5. Mueller TJ, Wu H, Greenberg RE, Hudes G, Topham N, Lessin SR, et al. Cutaneous metastases from genitourinary malignancies. Urology 2004;63:1021-6. https://doi.org/10.1016/j.urology.2004.01.014
  6. Hidaka T, Ishii Y, Kitamura S. Clinical features of skin metastasis from lung cancer. Intern Med 1996;35:459-62. https://doi.org/10.2169/internalmedicine.35.459
  7. Terashima T, Kanazawa M. Lung cancer with skin metastasis. Chest 1994;106:1448-50. https://doi.org/10.1378/chest.106.5.1448
  8. Kamble R, Kumar L, Kochupillai V, Sharma A, Sandhoo MS, Mohanti BK. Cutaneous metastases of lung cancer. Postgrad Med J 1995;71:741-3. https://doi.org/10.1136/pgmj.71.842.741
  9. Perng DW, Chen CH, Lee YC, Perng RP. Cutaneous metastasis of lung cancer: an ominous prognostic sign. Zhonghua Yi Xue Za Zhi (Taipei) 1996;57:343-7.
  10. Rubinstein RY, Baredes S, Caputo J, Galati L, Schwartz RA. Cutaneous metastatic lung cancer: literature review and report of a tumor on the nose from a large cell undifferentiated carcinoma. Ear Nose Throat J 2000; 79:96-7, 100-1.
  11. Barbetakis N, Samanidis G, Paliouras D, Samanidou E, Tzimorota Z, Asteriou C, et al. Facial skin metastasis due to small-cell lung cancer: a case report. J Med Case Reports 2009;3:32. https://doi.org/10.1186/1752-1947-3-32
  12. Coslett LM, Katlic MR. Lung cancer with skin metastasis. Chest 1990;97:757-9. https://doi.org/10.1378/chest.97.3.757
  13. Brownstein MH, Helwig EB. Spread of tumors to the skin. Arch Dermatol 1973;107:80-6. https://doi.org/10.1001/archderm.1973.01620160052015
  14. Chee RJ, Bydder S, Cameron F. Prolonged survival after resection and radiotherapy for solitary brain metastases from non-small-cell lung cancer. Australas Radiol 2007; 51:186-9. https://doi.org/10.1111/j.1440-1673.2007.01702.x
  15. Mercier O, Fadel E, de Perrot M, Mussot S, Stella F, Chapelier A, et al. Surgical treatment of solitary adrenal metastasis from non-small cell lung cancer. J Thorac Cardiovasc Surg 2005;130:136-40. https://doi.org/10.1016/j.jtcvs.2004.09.020
  16. Kim MS, Kook EH, Ahn SH, Jeon SY, Yoon JH, Han MS, et al. Gastrointestinal metastasis of lung cancer with special emphasis on a long-term survivor after operation. J Cancer Res Clin Oncol 2009;135:297-301. https://doi.org/10.1007/s00432-008-0424-0

Cited by

  1. Cutaneous metastasis as a initial presentation in advanced non-small cell lung cancer and its poor survival prognosis vol.138, pp.10, 2011, https://doi.org/10.1007/s00432-012-1239-6
  2. Scalp Metastasis as the First Sign of Small-Cell Lung Cancer: Management and Literature Review vol.99, pp.4, 2014, https://doi.org/10.9738/intsurg-d-13-00070.1
  3. Scalp metastasis as an initial presentation of lung adenocarcinoma : A case report and literature review vol.41, pp.None, 2011, https://doi.org/10.1016/j.ijscr.2017.10.060
  4. Cutaneous Metastasis as the First Symptom: An Uncommon Presentation of Squamous Cell Lung Cancer vol.130, pp.1, 2017, https://doi.org/10.4103/0366-6999.196584