Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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The Effect of Extracts of Berberis koreana Bark by Lactobacillus Fermentation on the Concentration of Serotonin and Melatonin in the Serum of Treated ICR Mice

유산균 발효된 매자나무 추출물이 마우스 혈청중의 Melatonin 및 Serotonin의 함량에 미치는 영향

  • Ling, Jin (College of Bioscience and Biotechnology, Kangwon National University) ;
  • Kim, Ji-Seon (Medical & Bio-Material Research Center and College of Bioscience and Biotechnology, Kangwon National University) ;
  • Seo, Yong-Chang (Medical & Bio-Material Research Center and College of Bioscience and Biotechnology, Kangwon National University) ;
  • Choi, Woon-Yong (College of Bioscience and Biotechnology, Kangwon National University) ;
  • Ahn, Ju-Hee (College of Bioscience and Biotechnology, Kangwon National University) ;
  • Ma, Choong-Je (College of Bioscience and Biotechnology, Kangwon National University) ;
  • Yoon, Chang-Soon (Shebah Biotech Co., Hallym Business Incubator/Industry-University) ;
  • Lee, Hyeon-Yong (College of Bioscience and Biotechnology, Kangwon National University)
  • ;
  • 김지선 (강원대학교 의료.바이오신소재융복합연구사업단) ;
  • 서용창 (강원대학교 의료.바이오신소재융복합연구사업단) ;
  • 최운용 (강원대학교 바이오산업공학부) ;
  • 안주희 (강원대학교 바이오산업공학부) ;
  • 마충제 (강원대학교 바이오산업공학부) ;
  • 윤창순 (세바바이오텍) ;
  • 이현용 (강원대학교 바이오산업공학부)
  • Received : 2010.11.05
  • Accepted : 2011.04.22
  • Published : 2011.04.30
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Abstract

This study was to investigate the effect of fermentation extracts on the concentration of serotonin and melatonin in the serum of the ICR mice. The ICR mice were divided into water control group, lactobacillus fermentation solution including (Lactobacillus paracasei and Bifidobacterium longum B6) control group, positive control group (milk and doxylamine succinate), negative control group (caffein) and the groups treated with the extracts of Berberis koreana bark (WE: water extracts, FE-L.P: fermentation extracts of Lactobacillus paracasei, FE-B.L: fermentation extracts of Bifidobacterium longum B6). After ten-day feeding treatment, the mean concentration of serotonin for water control, WE, FE-L.P and FEB. L group was 134.72, 183.01, 232.09 and $223.78 ng/m{\ell}$, respectively. The mean concentration for FE-L.P and FE-B.L group were approximately 66% larger than that for water control group. The mean concentration of melatonin for water control, WE, FE-L.P and FE-B.L group was 76.92, 106.66, 157.56 and $141.81pg/m{\ell}$, respectively. The mean concentration of melatonin for FE-L.P and FE-B.L group were also larger than that for water control group. Our results indicated that the fermentation extracts of Berberis koreana bark have relatively greater potential to induce secretion of serotonin and melatonin. Therefore, the fermentation extracts have antidepressant effect.

Keywords

References

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