Journal of Embryo Transfer (한국수정란이식학회지)

The Korean Society of Embryo Transfer (한국수정란이식학회)
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Comparison of Plasma Progesterone Concentrations between Spontaneous Delivery Bitches and Fetal Death Bitches

정상 분만견과 태아사 발생견에서의 혈장 Progesterone 농도 비교

  • Rae, Jae-Han (College of Veterinary Medicine, Chonnam National University) ;
  • Park, Chul-Ho (College of Veterinary Medicine, Chonnam National University) ;
  • Kim, Sang-Il (College of Veterinary Medicine, Chonnam National University) ;
  • Ryu, Jae-Sun (College of Veterinary Medicine, Chonnam National University) ;
  • Suh, Guk-Hyun (College of Veterinary Medicine, Chonnam National University) ;
  • Park, In-Chul (School of Veterinary Medicine, Kangwon National University) ;
  • Kim, Jong-Taek (School of Veterinary Medicine, Kangwon National University) ;
  • Oh, Ki-Seok (College of Veterinary Medicine, Chonnam National University) ;
  • Son, Chang-Ho (College of Veterinary Medicine, Chonnam National University)
  • Received : 2011.02.23
  • Accepted : 2011.03.02
  • Published : 2011.03.31
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Abstract

This study investigated potential relationship between fetal deaths and plasma progesterone concentrations of bitches. Serial ultrasonographic examinations were performed on small-pet 23 dogs from gestation day (GD) 15 through parturition. The dogs were 3 non-pregnant bitches, 9 spontaneous delivery bitches, 6 partial early embryonic death bitches, 2 whole early embryonic death bitches, and 3 aborted bitches. The late pregnancy (GD 51-54) appeared in 2 of the 3 aborted bitches and the hypoluteoidism appeared in 1 of the 3 aborted bitches. The plasma progesterone concentrations of partial early embryonic death bitches (n=6) showed no significant difference when compared with the spontaneous delivery bitches. We observed that plasma progesterone concentrations were dramatic decrease before the onset of embryonic death in whole early embryonic death bitches that plasma progesterone concentrations of aborted bitches at late pregnancy were significantly decreased when compared with those of spontaneous delivery bitches. The plasma progesterone concentrations of the hypoluteoidism bitch were lower than those of spontaneous delivery bitches. At the hypoluteoidism bitch, fetuses were resorbed in early pregnancy and aborted in late pregnancy. On the basis of the results, the diagnosis of partial early embryonic death could not be confirmed without ultrasonographic examination. The partial early embryonic death was considered a spontaneous phenomenon and uncorrelated with plasma progesterone concentration. However, aborted bitches and whole early embryonic death bitches were related to plasma progesterone concentrations and that of bitches gradually decreased before fetal death. These findings suggest that administration of progesterone may be a useful preventing agent against fetal death.

Keywords

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