Journal of Integrative Natural Science (통합자연과학논문집)

The Basic Science Institute Chosun University (조선대학교 기초과학연구원)
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Matrix Metalloproteinase: Inhibitory Effect of Marine Substances on MMP-2 and MMP-9

  • Nguyen, Van-Tinh (Department of Marine Life Science and Marine Life Research & Education Center, Chosun University) ;
  • Qian, Zhong-Ji (Department of Marine Life Science and Marine Life Research & Education Center, Chosun University) ;
  • Jung, Won-Kyo (Department of Marine Life Science and Marine Life Research & Education Center, Chosun University)
  • Received : 2011.10.07
  • Accepted : 2011.12.22
  • Published : 2011.12.30
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Abstract

Marine ecosystems are often characterized by a high biological diversity, and it corresponds to a high chemical diversity. Up to present, more than 20,000 new bioactive substances have been isolated from marine organisms, where considerable numbers of these naturally occurring derivatives are developed as potential candidates for pharmaceutical application. In this process, screening of natural products from marine organisms that could potentially inhibit the expression of metalloproteinases has gained a huge popularity. Cancer is considered as one of the deadliest diseases in the medical field. Matrix metalloproteinase (MMPs) can degrade extracellular matrix (ECM) components and play important roles in a variety of biological and pathological processes. Matrix metalloproteinase inhibitors (MMPIs) have been identified as potential therapeutic candidates for metastasis, arthritis, chronic inflammation and wrinkle formation.

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References

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