Pediatric Infection and Vaccine

The Korean Society of Pediatric Infectious Diseases (대한소아감염학회)
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Three Cases of Prevention Therapy to Reduce Perinatal HIV Transmission

사람면역결핍바이러스 수직감염 예방치료 3례

  • Lee, Jae Yo (Department of Pediatrics, National Medical Center) ;
  • Park, Hyang Mi (Department of Pediatrics, National Medical Center) ;
  • Hwang, Se Hee (Department of Pediatrics, National Medical Center) ;
  • Kim, Kyeung Eun (Department of Pediatrics, National Medical Center) ;
  • Shin, Hye Jung (Department of Pediatrics, National Medical Center) ;
  • Kim, Jae Yoon (Department of Pediatrics, National Medical Center)
  • 이재요 (국립중앙의료원 소아청소년과) ;
  • 박향미 (국립중앙의료원 소아청소년과) ;
  • 황세희 (국립중앙의료원 소아청소년과) ;
  • 김경은 (국립중앙의료원 소아청소년과) ;
  • 신혜정 (국립중앙의료원 소아청소년과) ;
  • 김재윤 (국립중앙의료원 소아청소년과)
  • Received : 2010.10.01
  • Accepted : 2010.10.24
  • Published : 2011.06.25
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Abstract

In 2008, the Joint United Nations Programme on HIV/AIDS (UNAIDS) estimated that about 430,000 children worldwide became infected with HIV, mostly through mother-to-child transmission (MTCT) during pregnancy, labor, delivery, or breastfeeding. The MTCT prevention program proved to be feasible and effective in reduction of perinatal HIV transmission. Three babies born from HIV-infected mothers were admitted to the National Medical Center in 2009. Only two women received antiretroviral (ARV) therapy during pregnancy, labor, and after delivery, and their infants received zidovudine (AZT) for 6 weeks. The outcome, after a follow-up period of 4 months to 16 months, was favorable in all patients. Thus, we emphasize the need for expansion of antenatal HIV screening of pregnant women, implemented for early HIV diagnosis and effective ARV therapy for reduction of perinatal HIV transmission.

The Joint United Nations Programme on HIV/AIDS (UNAIDS)의 통계에 의하면 2008년 한 해에 43만 명의 어린이가 HIV 에 감염된 것으로 보이며 대부분 수직감염에 의한 것으로 나타났다. 수직감염의 예방 프로그램은 이러한 감염을 줄일 수 있는 가장 효과적인 방법이다. 2009년 국립중앙의료원에는 HIV에 감염된 산모로부터 출생한 신생아 3명이 입원하였다. 이들의 산모 2명은 ARV 치료제를 투여하였고 1명은 투여하지 못했으며 3명의 환아에게는 모두 ARV 치료를 하였다. 추적관찰을 4개월에서 16개월 동안 실시한 결과 아직까지는 HIV 수직감염이 의심될 수 있는 혈청학적 검사의 특이 소견은 보이지 않고 있다. 임산부에 대한 HIV 산전검사의 확대, 조기진단 및 효과적인 ARV 치료만이 수직감염을 낮출 수 있을 것이며 저자는 이에 대한 수직감염 예방치료 3례를 경험하였기에 보고하는 바이다.

Keywords

References

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