Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Anti-Inflammatory Effects of Prunus mume Mixture in Colitis Induced by Dextran Sodium Sulfate

매실 혼합물이 DSS로 유도된 염증성 장질환 동물모델의 면역조절에 미치는 활성

  • Jin, Hai-Lan (College of Biomedical & Health Science, Department of Applied Biochemistry, Konkuk University) ;
  • Lee, Bo-Ram (College of Biomedical & Health Science, Department of Applied Biochemistry, Konkuk University) ;
  • Lim, Kyung-Jik (Chungju High School) ;
  • Debnath, Trishna (College of Biomedical & Health Science, Department of Applied Biochemistry, Konkuk University) ;
  • Shin, Heung-Mook (Department of Physiology, Collage of Oriental Medicine, Dongguk University) ;
  • Lim, Beong-Ou (College of Biomedical & Health Science, Department of Applied Biochemistry, Konkuk University)
  • 김해란 (건국대학교 충주캠퍼스 의료생명대학 응용생명과학과) ;
  • 이보람 (건국대학교 충주캠퍼스 의료생명대학 응용생명과학과) ;
  • 임경직 (충주 고등학교) ;
  • ;
  • 신흥묵 (동국대학교 한의대 생리학과) ;
  • 임병우 (건국대학교 충주캠퍼스 의료생명대학 응용생명과학과)
  • Received : 2010.07.30
  • Accepted : 2011.02.11
  • Published : 2011.02.28
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Abstract

This study was conducted to investigate the anti-inflammatory effects of Pruns mume, Schisandra chinensis, Chaenomeles sinensis-- Prunus mume mixtrue (PM) treatment on colitis induced in mice by dextran sodium sulfate (DSS) treatment. A total of 25 male BALB/c mice (average weight $20.7\;{\pm}\; 1.6 \;g$) were divided into 5 treatment groups and fed a commercial diet (A), PM administration (B), commercial diet + induced colitis by DSS (C), PM administration + induced colitis by DSS (D) and sulfasalazine + induced colitis by DSS (E). We found that PM treatment (D) and sulfasalazine (E) decreased the expression of $TNF-{\alpha}$ and COX-2 compared to the DSS-induced colitis group (C). The expression of IL-4, STAT6, $IFN-{\gamma}$, STAT1 was decreased in group D and group E compared to the colitis group (C), COX-2 and STAT1 were more decreased in group D. The serum IgE levels decreased in the PM treatment groups (C and D) compared to the non-PM treatment groups (A and B) although there was no significant difference between the PM treatment groups. It is notable that a therapeutic application of the PM extracts ameliorated DSS-induced colitis in mice.

Keywords

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