Journal of Korean Neurosurgical Society

  • 제49권1호
  • /
  • Pages.8-12
  • /
  • 2011
  • /
  • 2005-3711(pISSN)
  • /
  • 1598-7876(eISSN)
대한신경외과학회 (The Korean Neurosurgical Society)
권호 표지
DOI QR코드

DOI QR Code

Association of Toll-Like Receptor 5 Gene Polymorphism with Susceptibility to Ossification of the Posterior Longitudinal Ligament of the Spine in Korean Population

  • Chung, Won-Suk (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Nam, Dong-Hyun (Department of Biofunctional Medicine and Diagnostics, College of Korean Medicine, Sang Ji University) ;
  • Jo, Dae-Jean (Department of Neurosurgery, School of Medicine, Kyung Hee University) ;
  • Lee, Jun-Hwan (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung Hee University)
  • 투고 : 2010.10.17
  • 심사 : 2011.01.07
  • 발행 : 2011.01.28
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objective: Ossification of the posterior longitudinal ligament (OPLL) has a strong genetic component. Specific gene polymorphisms may be associated with OPLL in several genes which regulate calcification in chondrocytes, change of extracellular collagen matrix and secretions of many growth factors and cytokines controlling bone morphogenesis. Toll-like receptor 5 (TLR5) may playa role in the pathogenesis of OPLL by intermediate nuclear factor-kappa B (NF-${\kappa}B$). The current study focused on coding single nucleotide polymorphisms (SNPs) of TLR5 for a case-control study investigating the relationship between TLR5 and OPLL in a Korean population. Methods: A total of 166 patients with OPLL and 231 controls were recruited for a case-control association study investigating the relationship between SNPs of TLR5 gene and OPLL. Four SNPs were genotyped by direct sequencing (rs5744168, rs5744169, rs2072493, and rs5744174). SNP data were analyzed using the SNPStats, SNPAnalyzer, Haploview, and Helixtree programs. Multiple logistic regression analysis with adjustment for age and gender was performed to calculate an odds ratio (OR). Results: None of SNPs were associated with OPLL in three alternative models (codominant, dominant, and recessive models; p> 0.05). A strong linkage disequilibrium block, including all 4 SNPs, was constructed using the Gabriel method. No haplotype was significantly associated with OPLL in three alternative models. Conclusion: These results suggest that Toll-like receptor 5 gene may not be associated with ossification of the posterior longitudinal ligament risk in Korean population.

키워드

참고문헌

  1. Brasier AR : The NF-kappaB regulatory network. Cardiovasc Toxicol 6 : 111-130, 2006 https://doi.org/10.1385/CT:6:2:111
  2. Gilmore TD : Introduction to NF-kappaB : players, pathways, perspectives. Oncogene 25 : 6680-6684, 2006 https://doi.org/10.1038/sj.onc.1209954
  3. Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, et al. : The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410 : 1099-1103, 2001 https://doi.org/10.1038/35074106
  4. Inamasu J, Guiot BH, Sachs DC : Ossification of the posterior longitudinal ligament : an update on its biology, epidemiology, and natural history. Neurosurgery 58 : 1027-1039, 2006 https://doi.org/10.1227/01.NEU.0000215867.87770.73
  5. Jimi E, Ghosh S : Role of nuclear factor-kappaB in the immune system and bone. Immunol Rev 208 : 80-87, 2005 https://doi.org/10.1111/j.0105-2896.2005.00329.x
  6. Kawaguchi H, Kurokawa T, Hoshino Y, Kawahara H, Ogata E, Matsumoto T : Immunohistochemical demonstration of bone morphogenetic protein-2 and transforming growth factor-beta in the ossification of the posterior longitudinal ligament of the cervical spine. Spine (Phila Pa 1976) 17 : S33-S36, 1992 https://doi.org/10.1097/00007632-199203001-00007
  7. Kong Q, Ma X, Li F, Guo Z, Qi Q, Li W, et al. : COL6A1 polymorphisms associated with ossification of the ligamentum flavum and ossification of the posterior longitudinal ligament. Spine (Phila Pa 1976) 32 : 2834-2838, 2007 https://doi.org/10.1097/BRS.0b013e31815b761c
  8. Kosaka T, Imakiire A, Mizuno F, Yamamoto K : Activation of nuclear factor kappaB at the onset of ossification of the spinal ligaments. J Orthop Sci 5 : 572-578, 2000 https://doi.org/10.1007/s007760070008
  9. Lien E, Ingalls RR : Toll-like receptors. Crit Care Med 30 : S1-S11, 2002 https://doi.org/10.1097/00003246-200201001-00001
  10. Maeda S, Ishidou Y, Koga H, Taketomi E, Ikari K, Komiya S, et al. : Functional impact of human collagen alpha2(XI) gene polymorphism in pathogenesis of ossification of the posterior longitudinal ligament of the spine. J Bone Miner Res 16 : 948-957, 2001 https://doi.org/10.1359/jbmr.2001.16.5.948
  11. Perkins ND : Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol 8 : 49-62, 2007 https://doi.org/10.1038/nrm2083
  12. Sakou T, Matsunaga S, Koga H : Recent progress in the study of pathogenesis of ossification of the posterior longitudinal ligament. J Orthop Sci 5 : 310-315, 2000 https://doi.org/10.1007/s007760050169
  13. Sakou T, Taketomi E, Matsunaga S, Yamaguchi M, Sonoda S, Yashiki S : Genetic study of ossification of the posterior longitudinal ligament in the cervical spine with human leukocyte antigen haplotype. Spine (Phila Pa 1976) 16 : 1249-1252, 1991 https://doi.org/10.1097/00007632-199111000-00001
  14. Tahara M, Aiba A, Yamazaki M, Ikeda Y, Goto S, Moriya H, et al. : The extent of ossification of posterior longitudinal ligament of the spine associated with nucleotide pyrophosphatase gene and leptin receptor gene polymorphisms. Spine (Phila Pa 1976) 30 : 877-880; discussion 881, 2005 https://doi.org/10.1097/01.brs.0000160686.18321.ad
  15. Taketomi E, Sakou T, Matsunaga S, Yamaguchi M : Family study of a twin with ossification of the posterior longitudinal ligament in the cervical spine. Spine (Phila Pa 1976) 17 : S55-S56, 1992 https://doi.org/10.1097/00007632-199203001-00012
  16. Terayama K : Genetic studies on ossification of the posterior longitudinal ligament of the spine. Spine (Phila Pa 1976) 14 : 1184-1191, 1989 https://doi.org/10.1097/00007632-198911000-00009
  17. Trojan DA, Pouchot J, Pokrupa R, Ford RM, Adamsbaum C, Hill RO, et al. : Diagnosis and treatment of ossification of the posterior longitudinal ligament of the spine : report of eight cases and literature review. Am J Med 92 : 296-306, 1992 https://doi.org/10.1016/0002-9343(92)90080-U
  18. Tsuyama N : Ossification of the posterior longitudinal ligament of the spine. Clin Orthop Relat Res 184 : 71-84, 1984

피인용 문헌

  1. Identification and functional analysis of a novel single nucleotide polymorphism (SNP) in the porcine Toll like receptor (TLR) 5 gene vol.61, pp.4, 2011, https://doi.org/10.1080/09064702.2012.656140
  2. Association of TLR5 sequence variants and mRNA level with cytokine transcription in pigs vol.65, pp.2, 2011, https://doi.org/10.1007/s00251-012-0662-9
  3. Genetic diversity of Toll-like receptor 5 among pig populations vol.36, pp.1, 2011, https://doi.org/10.1590/s1415-47572013005000004
  4. A genome-wide sib-pair linkage analysis of ossification of the posterior longitudinal ligament of the spine vol.31, pp.2, 2013, https://doi.org/10.1007/s00774-012-0404-y
  5. Genetics of Ossification of the Posterior Longitudinal Ligament of the Spine: A Mini Review vol.21, pp.2, 2011, https://doi.org/10.11005/jbm.2014.21.2.127
  6. The Pathogenesis of Ossification of the Posterior Longitudinal Ligament vol.8, pp.5, 2017, https://doi.org/10.14336/ad.2017.0201
  7. Association of IL17RC and COL6A1 genetic polymorphisms with susceptibility to ossification of the thoracic posterior longitudinal ligament in Chinese patients vol.13, pp.None, 2011, https://doi.org/10.1186/s13018-018-0817-y
  8. Potential role of the IL17RC gene in the thoracic ossification of the posterior longitudinal ligament vol.43, pp.5, 2011, https://doi.org/10.3892/ijmm.2019.4130
  9. The COL6A1 rs201153092 single nucleotide polymorphism, associates with thoracic ossification of the posterior longitudinal ligament vol.21, pp.1, 2020, https://doi.org/10.3892/mmr.2019.10846