The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)

The Society of Korean Medicine Obstetrics and Gynecology (대한한방부인과학회)
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The Inhibitory Effect of Picrasmae Lignum on Inflammatory Responses

고목(苦木)의 염증 반응 억제 효과

  • Ryu, Ik-Han (Dept. of Oriental Gynecology, College of Oriental Medicine, Won-Kwang University) ;
  • Cho, Han-Baek (Dept. of Oriental Gynecology, College of Oriental Medicine, Won-Kwang University) ;
  • Kim, Song-Baeg (Dept. of Oriental Gynecology, College of Oriental Medicine, Won-Kwang University) ;
  • Seo, Yun-Jung (Dept. of Oriental Gynecology, College of Oriental Medicine, Won-Kwang University) ;
  • Choi, Chang-Min (Dept. of Oriental Gynecology, College of Oriental Medicine, Won-Kwang University)
  • 류익한 (원광대학교 한의과대학 부인과 교실) ;
  • 조한백 (원광대학교 한의과대학 부인과 교실) ;
  • 김송백 (원광대학교 한의과대학 부인과 교실) ;
  • 서윤정 (원광대학교 한의과대학 부인과 교실) ;
  • 최창민 (원광대학교 한의과대학 부인과 교실)
  • Received : 2011.01.28
  • Accepted : 2011.02.09
  • Published : 2011.02.28
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Abstract

Objectives: The purpose of this study was to investigate the anti-inflammatory effects of aqueous extract from Picrasmae Lignum(PL). Methods: To evaluate the anti-inflammatory effects of PL extract, the productions of NO, PGE2 and expression of pro-inflammatory cytokine(IL-1b, IL-6 and TNF-a) were measured in LPS-induced RAW 264.7 cells. Furthermore Western blot analysis has been done to look into the inhibitory mechanisms such as MAPKs and NF-kB. Results: PL extract down-regulated LPS-induced NO, PGE2, IL-1b, IL-6 and TNF-a productions mainly through JNK and p38 MAPK pathway and NF-kB pathway. Conclusions: These results suggest that PL extract may be effective for the treatment of inflammatory diseases.

Keywords

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