Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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Bone response around immediately placed titanium implant in the extraction socket of diabetic and insulin-treated rat maxilla

인슐린으로 조절되는 당뇨쥐 상악에서 발치 후 즉시 임플란트 주변에서 골형성

  • Kim, Dae-Won (Department of Oral and Maxillofacial Surgery, Graduate School of Clinical Dental Science, The Catholic University of Korea) ;
  • Heo, Hyun-A (Division of Oral and Maxillofacial Surgery, Department of Dentistry, School of Medicine, The Catholic University of Korea) ;
  • Lim, Sang-Gyu (Division of Oral and Maxillofacial Surgery, Department of Dentistry, School of Medicine, The Catholic University of Korea) ;
  • Lee, Won (Department of Oral and Maxillofacial Surgery, Graduate School of Clinical Dental Science, The Catholic University of Korea) ;
  • Kim, Young-Sil (Department of Pathology, College of Medicine, Jeju National University) ;
  • Pyo, Sung-Woon (Department of Oral and Maxillofacial Surgery, Graduate School of Clinical Dental Science, The Catholic University of Korea)
  • 김대원 (가톨릭대학교 임상치과학대학원 구강악안면외과학) ;
  • 허현아 (가톨릭대학교 의과대학 치과학교실 구강악안면외과) ;
  • 임상규 (가톨릭대학교 의과대학 치과학교실 구강악안면외과) ;
  • 이원 (가톨릭대학교 임상치과학대학원 구강악안면외과학) ;
  • 김영실 (제주대학교 의과대학 병리학교실) ;
  • 표성운 (가톨릭대학교 임상치과학대학원 구강악안면외과학)
  • Received : 2010.09.28
  • Accepted : 2011.01.20
  • Published : 2011.02.28
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Abstract

Introduction: Dental implants are used routinely with high success rates in generally healthy individuals. By contrast, their use in patients with diabetes mellitus is controversial because altered bone healing around implants has been reported. This study examined the bone healing response around titanium implants placed immediately in rats with controlled and uncontrolled diabetes. Materials and Methods: Twenty rats were divided into the control, insulin-treated and diabetic groups. The rats received streptozotocin (60 mg/kg) to induce diabetes; animals in the insulin-treated group also received three units of subcutaneous slow-release insulin. A titanium implant ($1.2{\times}3\;mm$) was placed in the extraction socket of the maxillary first molar and bone block was harvested at 1, 2 and 4 weeks. Results: Bone formation around the implants was consistently (from 1 to 4 week post-implantation) slower for the diabetic group than the control and insulin-treated group. Bone morphogenesis in the diabetic rats was characterized by fragmented bone tissues and extensive soft tissue intervention. Conclusion: The immediate placement of titanium implants in the maxilla of diabetic rats led to an unwanted bone healing response. These results suggest that immediate implant insertion in patients with poorly controlled diabetes might be contraindicated.

Keywords

References

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