Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Effects of Intraperitoneal Bupivacaine Instillation on Postoperative Pain Behavior after Laparoscopic Ovariohysterectomy in Dogs

개에서 복강경을 이용한 난소자궁절제술시 복강 내 Bupivacaine의 점적투여가 술 후 통증행동에 미치는 영향

  • Kim, Young-Ki (Lab. of Veterinary Surgery and Behavior, College of Veterinary Medicine, Gyeongsang National University) ;
  • Lee, Seung-Yong (Lab. of Veterinary Surgery and Behavior, College of Veterinary Medicine, Gyeongsang National University) ;
  • Park, Se-Jin (Lab. of Veterinary Surgery and Behavior, College of Veterinary Medicine, Gyeongsang National University) ;
  • Lee, Scott-S. (Lab. of Veterinary Surgery and Behavior, College of Veterinary Medicine, Gyeongsang National University) ;
  • Suh, Euy-Hoon (Department of Statistics College of Natural Science, Gyeongsang National University) ;
  • Chang, Hong-Hee (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Lee, Hee-Chun (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Lee, Hyo-Jong (Lab. of Veterinary Surgery and Behavior, College of Veterinary Medicine, Gyeongsang National University) ;
  • Yeon, Seong-Chan (Lab. of Veterinary Surgery and Behavior, College of Veterinary Medicine, Gyeongsang National University)
  • 김영기 (경상대학교 수의과대학 수의외과.행동학 연구실) ;
  • 이승용 (경상대학교 수의과대학 수의외과.행동학 연구실) ;
  • 박세진 (경상대학교 수의과대학 수의외과.행동학 연구실) ;
  • 이시경 (경상대학교 수의과대학 수의외과.행동학 연구실) ;
  • 서의훈 (경상대학교 정보통계학과) ;
  • 장홍희 (경상대학교 수의과대학 동물의학연구소) ;
  • 이희천 (경상대학교 수의과대학 동물의학연구소) ;
  • 이효종 (경상대학교 수의과대학 수의외과.행동학 연구실) ;
  • 연성찬 (경상대학교 수의과대학 수의외과.행동학 연구실)
  • Accepted : 2010.11.17
  • Published : 2011.02.28
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Abstract

The present study was aimed to investigate the effect of intraperitoneal bupivacaine instillation on postoperative pain after laparoscopic ovariohysterectomy (LOHE) in dogs. Twelve female German shepherd dogs (17-30 kg) were divided into two groups. The treatment group received 4.4 mg/kg of instilled intraperitoneal bupivacaine diluted to 0.25% with an equivalent volume of saline after pneumoperitoneum, but the control group received 1.76 ml/kg of 0.9% saline. Two blind observers measured the extent of dog's pain and sedation by using dynamic interactive visual analogue scale (DIVAS) preoperatively and 0.5, 1, 2, 4, 6, and 12 h postoperatively. At each designated time, blood cortisol, glucose, and creatine kinase (CK) concentrations were also measured. Based on the repeated-measures ANOVA, there were significant differences in time-dependent postoperative changes in patterns of DIVAS-pain score between two groups. In addition, the treatment group had significantly lower DIVAS-pain scores at 1, 2, 4, and 6 h postoperatively compared to the control group. DIVAS-sedation score and biochemical measures including cortisol, glucose, and CK did not show any significant differences between two groups. No complications associated with bupivacaine administration were observed. Thus, instilled bupivacaine intraperitoneally may be an effective method on relieving behavioral expressions associated with postoperative pain after laparoscopic ovariohysterectomy in dogs.

Keywords

References

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