한국임상약학회지 (Korean Journal of Clinical Pharmacy)

  • 제21권1호
  • /
  • Pages.39-42
  • /
  • 2011
  • /
  • 1226-6051(pISSN)
  • /
  • 2508-786X(eISSN)
한국임상약학회 (Korean College Of Clinical Pharmacy)
권호 표지

위나선균양성 특발성혈소판감소성자반증에서 위나선균박멸요법의 효과: 증례 연구

The Effect of Helicobacter pylori eradication in Patients with H. pylori(+) Idiopathic thrombocytopenic Purpura : Case study

  • 박치영 (조선대학교 병원 내과) ;
  • 문홍섭 (조선대학교 병원 약제부)
  • Park, Chi-Young (Department of Internal Medicine, Chosun University Hospital) ;
  • Moon, Hong-Seop (Department of Pharmacy, Chosun University Hospital)
  • 투고 : 2010.12.13
  • 심사 : 2011.02.17
  • 발행 : 2011.03.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Idiopathic thrombocytopenic purpura is a potentially life-threatening condition characterised by thrombocytopenia and mediated by an autoimmune mechanism. Several recent studies have suggested that an association exists between H. pylori eradication and improvement in platelet count in a significant proportion of patients with idiopathic thrombocytopenic purpura. This study confirmed the efficacy of H. pylori eradication in increasing the platelet count in steroid refractory idiopathic thrombocytopenic purpura patients. Eradication therapy is simple and inexpensive, with limited toxicity and the advantage of avoiding long-term immunosuppressive treatment.

키워드

참고문헌

  1. Psaila B, Bussel JB. Immune thrombocytopenic purpura. Hematol Oncol Clin North Am 2007; 21: 743-59. https://doi.org/10.1016/j.hoc.2007.06.007
  2. George JN, Woolf SH, Raskob GE, et al., Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology. Blood 1996; 88: 3-40.
  3. 이재범, 문영철, 박혜성 등, 스테로이드 치료에 실패한 만성 면역혈소판감소자색반 환자에서 2차 치료로 다나졸의 치료성적. Korean J Hematol 2007; 42: 353-60. https://doi.org/10.5045/kjh.2007.42.4.353
  4. Vianelli N, ValdrL, Fiacchini M, et al., Long-term followup of idiopathic thrombocytopenic purpura in 310 patients. Haematologica 2001; 86: 504-9.
  5. Michel M, Khellaf M, Desforges L, et al., Autoimmune thrombocytopenic purpura and Helicobacter pylori infection. Arch Intern Med 2002; 162: 1033-6. https://doi.org/10.1001/archinte.162.9.1033
  6. Takahashi T, Yujiri T, Shinohara K, et al., Molecular mimicry by Helicobacter pylori CagA protein may be involved in the pathogenesis of H. pylori.associated chronic idiopathic thrombocytopenic purpura. Br J Haematol 2004; 124: 916.
  7. Figura N, Giordano N, Burroni D, et al., Sjogren's syndrome and Helicobacter pylori infection. Eur J Gastroenterol Hepatol 1994; 6: 321-2.
  8. De Luis DA, Varela C, de la Calle H. Helicobacter pylori infection is markedly increased in patients with autoimmune atrophic thyroiditis. J Clin Gastroenterol 1998; 26: 259-63. https://doi.org/10.1097/00004836-199806000-00008
  9. Zentilin P, Savarino V, Garnero A, et al., Is Helicobacter pylori infection a risk factor for disease severity in rheumatoid arthritis? Gastroenterology 1999; 116: 503-4. https://doi.org/10.1016/S0016-5085(99)70161-7
  10. Gasbarrini A, Franceschi F, Tartaglione R, et al., Regression of autoimmune thrombocytopenia after eradication of Helicobacter pylori. Lancet 1998; 352: 878.
  11. Logan RP, Walker MM. ABC of the upper gastrointestinal tract: epidemiology and diagnosis of Helicobacter pylori infection. BMJ 2001; 323: 920-2. https://doi.org/10.1136/bmj.323.7318.920
  12. Ahn ER, Tiede MP, Jy W, et al., Platelet activation in Helicobacter pylori-associated idiopathic thrombocytopenic purpura: eradication reduces platelet activation but seldom improves platelet counts. Acta Haematol. 2006; 116: 19-24. https://doi.org/10.1159/000092343
  13. Nomura S, Inami N, Kanazawa S. The effects of Helicobacter pylori eradication on chemokine production in patients with immune thrombocytopenic purpura. Eur J Haematol 2004; 72: 304-5. https://doi.org/10.1111/j.1600-0609.2004.00220.x
  14. 김봉석, 남승현, 방수미 등., Helicobacter pylori 양성 만성 특발성혈소판감소성자반증 환자에서 Helicobacter pylori 박멸요법의 효과. Korean J Hematol 2005; 40: 23-7. https://doi.org/10.5045/kjh.2005.40.1.23
  15. Rostami N, Keshtkar-Jahromi M, Rahnavardi M, et al., Effect of eradication of Helicobacter pylori on platelet recovery in patients with chronic idiopathic thrombocytopenic purpura: a controlled trial. Am J Hematol 2008; 83: 376-81. https://doi.org/10.1002/ajh.21125
  16. Stasi R, Sarpatwari A, Segal JB, et al., Effects of eradication of Helicobacter pylori infection in patients with immune thrombocytopenic purpura: a systematic review. Blood 2009; 113: 1231-40. https://doi.org/10.1182/blood-2008-07-167155