The Journal of Korean Physical Therapy

The Korean Society of Physical Therapy (대한물리치료학회)
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The Ongoing Effect of Transcranial Direct Current Stimulation on both the Hemispheres: Single Case fMRI Study

  • Kwon, Jung-Won (Department of Rehabilitation Science, Graduate School, Daegu University) ;
  • Son, Sung-Min (Department of Rehabilitation Science, Graduate School, Daegu University) ;
  • Kim, Chung-Sun (Department of Physical Therapy, College of Rehabilitation, Daegu University) ;
  • Cho, In-Sul (Department of Physical Therapy, Yeungnam College of Science and Technology)
  • Received : 2011.10.28
  • Accepted : 2011.11.26
  • Published : 2011.12.26
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Abstract

Purpose: The purpose of this study is to investigate whether dual-hemisphere transcranial direct current stimulation (tDCS) could induce more cortical activity, compared to single-hemisphere, using functional MRI (fMRI). Methods: One right-handed healthy subject was recruited. Three phases of dual-hemisphere tDCS (i.e. anodal tDCS over the left-dominant primary sensoriomotor cortex (SM1) and cathodal tDCS over the right-non dominant SM(1) were consecutively delivered on to a subject, during fMRI scanning. The voxel count and the intensity index in the averaged cortical map were analyzed among the three tDCS phases. Results: Our result showed that cortical activation was observed on all the three phases of the dual-hemisphere tDCS. Voxel count and intensity index were as following; 912 and 4.07 in the first phase, 1102 and 3.90 in the second phase, 1031 and 3.80 in the third phase. Conclusion: This study demonstrated that application of the dual-hemisphere tDCS could induce cortical activity and maintain to recruit cortical neurons. Our findings suggested that application of dual-hemisphere tDCS could produce efficiency of the ongoing tDCS effect to facilitate cortical excitability.

Keywords

References

  1. Park JW, Kwon YH, Lee MY et al. Brain activation pattern according to exercise complexity: a functional mri study. NeuroRehabilitation. 2008;23(3):283-288.
  2. Leonard C. The neuroscience of human movement. St Louis, Mosby, 1998:125-150.
  3. Kandal E, Schwartz J, Jessell T. Principles of neural science (Internation Edition). New York, Mcgraw-Hill, 2000:440-466.
  4. Kaplan MS. Plasticity after brain lesions: contemporary concepts. Arch Phys Med Rehabil. 1988;69(11):984-991.
  5. Antal A, Nitsche MA, Paulus W. Transcranial magnetic and direct current stimulation and the visual cortex. Brain Res Bull. 2006;68(6):459-463. https://doi.org/10.1016/j.brainresbull.2005.10.006
  6. Reis J, Robertson E, Krakauer JW et al. Consensus: "Can tdcs and tms enhance motor learning and memory formation?". Brain Stimul. 2008;1(4):363-369. https://doi.org/10.1016/j.brs.2008.08.001
  7. Nitsche MA, Liebetanz D, Antal A et al. Modulation of cortical excitability by weak direct current stimulation--technical, safety and functional aspects. Suppl Clin Neurophysiol. 2003;56(1):255-276.
  8. Lefaucheur JP. Methods of therapeutic cortical stimulation. Neurophysiol Clin. 2009;39(1):1-14. https://doi.org/10.1016/j.neucli.2008.11.001
  9. Been G, Ngo TT, Miller SM et al. The use of tdcs and cvs as methods of non-invasive brain stimulation. Brain Res Rev. 2007;56(2):346-361. https://doi.org/10.1016/j.brainresrev.2007.08.001
  10. Paulus W. Transcranial direct current stimulation (tdcs). Suppl Clin Neurophysiol. 2003;56(1):249-254.
  11. Antal A, Nitsche MA, Kincses TZ et al. Facilitation of visuo-motor learning by transcranial direct current stimulation of the motor and extrastriate visual areas in humans. Eur J Neurosci. 2004;19(10):2888-2892. https://doi.org/10.1111/j.1460-9568.2004.03367.x
  12. Iyer MB, Mattu U, Grafman J et al. Safety and cognitive effect of frontal dc brain polarization in healthy individuals. Neurology. 2005;64(5):872-875. https://doi.org/10.1212/01.WNL.0000152986.07469.E9
  13. Dockery CA, Hueckel-Weng R, Birbaumer N et al. Enhancement of planning ability by transcranial direct current stimulation. J Neurosci. 2009;29(22):7271-7277 https://doi.org/10.1523/JNEUROSCI.0065-09.2009
  14. Fregni F, Boggio PS, Mansur CG et al. Transcranial direct current stimulation of the unaffected hemisphere in stroke patients. Neuroreport. 2005;16(14):1551-1555. https://doi.org/10.1097/01.wnr.0000177010.44602.5e
  15. Hummel FC, Cohen LG. Non-invasive brain stimulation: a new strategy to improve neurorehabilitation after stroke? Lancet Neurol. 2006;5(8):708-712. https://doi.org/10.1016/S1474-4422(06)70525-7
  16. Nitsche MA, Cohen LG, Wassermann EM et al. Transcranial direct current stimulation: state of the art 2008. Brain Stimul. 2008;1(3):206-223. https://doi.org/10.1016/j.brs.2008.06.004
  17. Schlaug G, Renga V. Transcranial direct current stimulation: A noninvasive tool to facilitate stroke recovery. Expert Rev Med Devices. 2008;5(6):759-768. https://doi.org/10.1586/17434440.5.6.759
  18. Sparing R, Thimm M, Hesse MD et al. Bidirectional alterations of interhemispheric parietal balance by non-invasive cortical stimulation. Brain. 2009;132(Pt 11):3011-3020.
  19. Vines BW, Cerruti C, Schlaug G. Dual-hemisphere tdcs facilitates greater improvements for healthy subjects' non-dominant hand compared to uni-hemisphere stimulation. BMC Neurosci. 2008;9(1):103. https://doi.org/10.1186/1471-2202-9-103
  20. Oldfield RC. The assessment and analysis of handedness: the edinburgh inventory. Neuropsychologia. 1971;9(1):97-113. https://doi.org/10.1016/0028-3932(71)90067-4
  21. Yousry TA, Schmid UD, Alkadhi H et al. Localization of the motor hand area to a knob on the precentral gyrus. a new landmark. Brain. 1997;120(Pt 1):141-157. https://doi.org/10.1093/brain/120.1.141
  22. Ugurbil K, Ogawa S, Kim S et al. Imaging brain activity using nuclear spins. Amsterdam, IOS Press, 1999:261-310.
  23. Waldvogel D, van Gelderen P, Immisch I et al. The variability of serial fmri data: correlation between a visual and a motor task. Neuroreport. 2000;11(17):3843-3847. https://doi.org/10.1097/00001756-200011270-00048
  24. Kwon YH, Ko MH, Ahn SH et al. Primary motor cortex activation by transcranial direct current stimulation in the human brain. Neurosci Lett. 2008;435(1):56-59. https://doi.org/10.1016/j.neulet.2008.02.012
  25. Kwon YH, Nam KS, Lee MY et al. The temporal change of cortical activation induced by the ongoing effects of transcranial direct current stimulation. Journal of Physical Therapy Science. 2011;23(1):65-69. https://doi.org/10.1589/jpts.23.65
  26. Lim YE, Kim SH, Yang DJ et al. Change of cerebral motor area activity by anodal transcranial direct current stimulation (tDCS). J Kor Soc Phys Ther. 2009;21(4):65-71.
  27. Kwon YH, Kim CS, Jang SH. Cortical activation in the human brain induced by transcranial direct current stimulation. J Kor Soc Phys Ther. 2009;21(4):73-79.
  28. Stone DB, Tesche CD. Transcranial direct current stimulation modulates shifts in global/local attention. Neuroreport. 2009;20(12):1115-1119.