Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)

Korean society of Clincal Toxicology (대한임상독성학회)
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Nicolau Syndrome following Diclofenac Injection in an Emergency Department

응급실에서 디클로페낙 근주 후 발생한 니콜라우 증후군 1례

  • Chung, Sang-Won (Department of Emergency Medicine, Kwandong University College of Medicine) ;
  • Kang, Ji-Hoon (Department of Emergency Medicine, Kwandong University College of Medicine) ;
  • Yeo, Jun-Mo (Department of Emergency Medicine, Kwandong University College of Medicine) ;
  • Ko, Jai-Woog (Department of Emergency Medicine, Kwandong University College of Medicine)
  • 정상원 (관동대학교 의과대학 응급의학교실) ;
  • 강지훈 (관동대학교 의과대학 응급의학교실) ;
  • 여준모 (관동대학교 의과대학 응급의학교실) ;
  • 고재욱 (관동대학교 의과대학 응급의학교실)
  • Received : 2011.06.20
  • Accepted : 2011.08.18
  • Published : 2011.12.31
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Abstract

Nicolau syndrome is a rare adverse reaction at the site of an intramuscular injection, and is characterized by severe pain immediately after the injection and rapid development of distinct skin lesions. As this syndrome is rare, it may be overlooked at the early clinical phase and subsequently, clinical outcomes may be worse due to delay in treatment. We report on a female who developed Nicolau syndrome following intramuscular diclofenac injection, which required surgical reconstruction. Understanding the characteristics of Nicolau syndrome and careful surveillance for relevant clinical features may help physicians to more quickly diagnose and treat this condition.

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