Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Sterols from Lindera glauca Blume Stem Wood

  • Huh, Gyu-Won (The Graduate School of Biotechnology, Kyung Hee University) ;
  • Park, Ji-Hae (The Graduate School of Biotechnology, Kyung Hee University) ;
  • Shrestha, Sabina (The Graduate School of Biotechnology, Kyung Hee University) ;
  • Lee, Youn-Hyung (Department of Horticultural Biotechnology, Kyung Hee University) ;
  • Ahn, Eun-Mi (Department of Herbal Foodceutical Science, Daegu Haany University) ;
  • Kang, Hee-Cheol (GFC Co., Ltd.) ;
  • Baek, Nam-In (The Graduate School of Biotechnology, Kyung Hee University)
  • Received : 2011.08.02
  • Accepted : 2011.10.25
  • Published : 2011.12.31
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Abstract

Chipped stem wood from Lindera glauca was extracted repeatedly with 80% aqueous methanol at room temperature, and the concentrated methanolic extract was successively partitioned with ethyl acetate (EtOAc), n-butyl alcohol, and $H_2O$. From the EtOAc fraction, four sterols were isolated through a repeated silica gel and octadecyl silica gel column chromatography. The chemical structures of the sterols were elucidated as ${\beta}$-sitosterol (1), 7-ketositosterol (2), 7${\beta}$-hydroxysitosterol (3), and daucosterol (4). Among them, compounds 2 and 3 were isolated for the first time from the stem woods of this plant.

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References

  1. Chang YC, Chang FR, and Wu YC (2000) The constituents of Lindera glauca. J Chin Chem Soc 47, 373-380.
  2. Chang YC, Chen CY, Chang FR, and Wu YC (2001) Alkaloids from Lindera glauca. J Chin Chem Soc 48, 811-815.
  3. Chaurasia N and Wicht M (1987) Sterols and steryl glycosides from Urtica dioica. J Nat Prod 50, 881-885. https://doi.org/10.1021/np50053a018
  4. Chung BS and Shin MK (1990) In Dictionary of Korean Folk Medicine. pp. 456-457, Young Lim Sa, Seoul, Korea.
  5. Cui EJ, Park JH, Park HJ, Chung IS, Kim JY, Yeon SW, and Baek NI (2011) Isolation of sterols from cowpea (Vigna sinensis) seeds and their promotion activity on HO-1. J Korean Soc Appl Biol Chem 54, 362-366. https://doi.org/10.3839/jksabc.2011.057
  6. El-Desouki HM and Al-Omair MA (2007) Salvia officinalis infusion improves liver antioxidant status and protects from hypercholesterolemia. Biochemistry: An Indian J 1, 117-121.
  7. Kolak U, Topcu G, Birteksoz S, Otuk G, and Ulubelen A (2005) Terpenoids and steroids from the roots of Salvia blepharochlaena. Turk J Chem 29, 177-186.
  8. Lee TB (1998) In Coloured Flora of Korea. p. 404. Hyangmunsa, Seoul, Korea.
  9. Luo W, Zhao MM, Yang B, Shen GL, and Rao GH (2009) Identification of bioactive compounds in Phyllenthus emblica L. fruit and their free radical scavenging activities. Food Chem 114, 499-504. https://doi.org/10.1016/j.foodchem.2008.09.077
  10. Nii H, Furukawa K, Iwakiri M, and Kubota T (1983a) A new sesquiterpene carboxylic acid from Lindera glauca (Sieb. et Zucc.) Blume. Nippon Nogei Kagaku Kaishi 57, 725-732. https://doi.org/10.1271/nogeikagaku1924.57.725
  11. Nii H, Furukawa K, Iwakiri M, and Kubota T (1983b) Constituents of the essential oils from Lindera glauca (Sieb. et Zucc.) Blume. Nippon Nogei Kagaku Kaishi 57, 733-741. https://doi.org/10.1271/nogeikagaku1924.57.733
  12. Seki K, Sasaki T, Haga K, and Kaneko R (1994) Two methoxybutanolides from Lindera glauca. Phytochemistry 36, 949-951. https://doi.org/10.1016/S0031-9422(00)90469-2
  13. Seki K, Sasaki T, Wano S, Haga K, and Kaneko R (1995) Linderanolides and isolinderanolides, ten butanolides from Lindera glauca. Phytochemistry 40, 1175-1181. https://doi.org/10.1016/0031-9422(95)00399-R
  14. Wang R, Tang S, Zhai H, and Duan H (2011) Studies on anti-tumor metastatic constituents from Lindera glauca. Zhongguo Zhong Yao Za Zhi 36, 1032-1036.
  15. Zhao CC, Shao JH, Li X, Xu J, and Zhang P (2005) Antimicrobial constituents from fruits of Ailanthus altissima SWINGLE. Arch Pharm Res 28, 1147-1151. https://doi.org/10.1007/BF02972977

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