Reproductive and Developmental Biology

The Korean Society of Animal Reproduction (한국동물번식학회)
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Novel Disease Model of Chronic Neutrophilic Leukemia

  • Seo, Byoung-Boo (Dept. of Animal Resources, College of Life & Environmental Science, Daegu University) ;
  • Min, Sung-Hun (Dept. of Biotechnology, College of Engineering, Daegu University) ;
  • Lee, Eun-Ji (Dept. of Obstetrics and Gynecololgy, Yeung nam University) ;
  • Ryoo, Zae-Young (School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University) ;
  • Park, Hum-Dai (Dept. of Biotechnology, College of Engineering, Daegu University)
  • Received : 2011.11.01
  • Accepted : 2011.06.11
  • Published : 2011.12.31
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Abstract

The experimental manipulation of protooncogenes and their gene products is a valuable research tool for the study of human neoplasia. In this study, the recently identified human cervical cancer protooncogene (HccR-2) was expressed in transgenic mice under the control of the tetracycline regulatory system. The phenotype observed was similar in many respects to human chronic neutrophilic leukemia (CNL). Thus, the HccR-2 transgenic mouse model is important not only for investigating the biological properties of the HccR-2 protooncogene in vivo, but also for analyzing the mechanisms involved in the progression of CNL.

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References

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