Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Gd-complexes of DTPA-bis(amide) Conjugates of Phosphonated Tranexamic Esters as MRI Contrast Agents

  • Patel, Mehul A. (Department of Applied Chemistry, Kyungpook National University) ;
  • Kim, Hee-Kyung (Department of Medical & Biological Engineering, Kyungpook National University) ;
  • Lee, Gang-Ho (Department of Chemistry, Kyungpook National University) ;
  • Chang, Yong-Min (Department of Medical & Biological Engineering, Kyungpook National University) ;
  • Kim, Tae-Jeong (Department of Applied Chemistry, Kyungpook National University)
  • Received : 2010.12.13
  • Accepted : 2011.01.18
  • Published : 2011.03.20
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Abstract

The syntheses of DTPA-bis(amide) conjugates of phosphonated cyclohexane moieties (5a-d) and their Gd(III) complexes of the type $[Gd(L)(H_2O)]{\cdot}nH_2O$ (6a-d; L = 5a-d) are described. All new compounds have been characterized by microanalysis and spectroscopic techniques. High $r_1$ relaxivities of aqueous solutions of 6a-d are observed to be in the range of $10.7-18.3\;mM^{-1}sec^{-1}$, which compare much better than that of $Omniscan^{(R)}$ ($r_1=3.90\;mM^{-1}sec^{-1}$).

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