IMMUNE NETWORK

The Korean Association of Immunobiologists (대한면역학회)
권호 표지
DOI QR코드

DOI QR Code

Role of Salvia miltiorrhiza for Modulation of Th2-derived Cytokines in the Resolution of Inflammation

  • Received : 2011.10.04
  • Accepted : 2011.10.13
  • Published : 2011.10.31
Download PDF
⟨ Previous Next ⟩

Abstract

Background: Salvia miltiorrhiza (SM) has been used to treat inflammatory diseases including edema and arthritis; however, the anti-inflammatory mechanism of SM action remains unresolved. Methods: The effects of an ethanol extract of SM (ESM) on pro-inflammatory cytokines such as TNF-${\alpha}$, IL-$1{\beta}$, IL-6, and NO, and on anti-inflammatory cytokines including IL-4, IL-10, TGF-${\beta}$, and IL-1Ra have been studied in an attempt to elucidate the anti-inflammatory mechanism in murine macrophages. Results: ESM inhibited the production of pro-inflammatory cytokines via down-regulation of gene and protein expression whereas it increased the anti-inflammatory cytokines. Furthermore, ESM inhibited the expression of the chemokines, RANTES and CX3CL1, as well as of inflammatory mediators such as TLR-4 and $11{\beta}$-HSD1. Conclusion: These results indicated that the regulatory effects of ESM may be mediated though the suppression of pro-inflammatory cytokines as well as the induction of anti-inflammatory cytokines. Consequently, we speculate that ESM has therapeutic potential for inflammation-associated disorders.

Keywords

References

  1. Opal SM, DePalo VA: Anti-inflammatory cytokines. Chest 117;1162-1172, 2000. https://doi.org/10.1378/chest.117.4.1162
  2. Lind L: Circulating markers of inflammation and atherosclerosis. Atherosclerosis 169;203-214, 2003. https://doi.org/10.1016/S0021-9150(03)00012-1
  3. Tilg H, Wilmer A, Vogel W, Herold M, Nolchen B, Judmaier G, Huber C: Serum levels of cytokines in chronic liver diseases. Gastroenterology 103;264-274, 1992. https://doi.org/10.1016/0016-5085(92)91122-K
  4. Coker RK, Laurent GJ: Pulmonary fibrosis: cytokines in the balance. Eur Respir J 11;1218-1221, 1998. https://doi.org/10.1183/09031936.98.11061218
  5. Charo IF, Ransohoff RM: The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med 354;610-621, 2006. https://doi.org/10.1056/NEJMra052723
  6. Dinarello CA: Proinflammatory cytokines. Chest 118;503-508, 2000. https://doi.org/10.1378/chest.118.2.503
  7. Nair MP, Kandaswami C, Mahajan S, Chadha KC, Chawda R, Nair H, Kumar N, Nair RE, Schwartz SA: The flavonoid, quercetin, differentially regulates Th-1 (IFNgamma) and Th-2 (IL4) cytokine gene expression by normal peripheral blood mononuclear cells. Biochim Biophys Acta 1593; 29-36, 2002. https://doi.org/10.1016/S0167-4889(02)00328-2
  8. McKellar G, Madhok R, Singh G: The problem with NSAIDs: what data to believe? Curr Pain Headache Rep 11; 423-427, 2007. https://doi.org/10.1007/s11916-007-0228-y
  9. Kim JK: Illustrated Natural Drugs Encyclopedia. Seoul: Namsandan Publishers; 1989.
  10. Dweck A: The folklore and cosmetic use of various Salvia species. In: Kintzios SE, editor. Sage The Genus Salvia. New York: Overseas Publishers p1-25, 2000.
  11. Duke J, Ayensu E: Medicinal Plants of China. Algonac, Mich: Reference Publications; 1985.
  12. Ji XY, Tan BK, Zhu YZ: Salvia miltiorrhiza and ischemic diseases. Acta Pharmacol Sin 21;1089-1094, 2000.
  13. Ding M, Ye TX, Zhao GR, Yuan YJ, Guo ZX: Aqueous extract of Salvia miltiorrhiza attenuates increased endothelial permeability induced by tumor necrosis factor-alpha. Int Immunopharmacol 5;1641-1651, 2005. https://doi.org/10.1016/j.intimp.2005.05.005
  14. Chen TH, Hsu YT, Chen CH, Kao SH, Lee HM: Tanshinone IIA from Salvia miltiorrhiza induces heme oxygenase-1 expression and inhibits lipopolysaccharide-induced nitric oxide expression in RAW 264.7 cells. Mitochondrion 7; 101-105, 2007. https://doi.org/10.1016/j.mito.2006.11.018
  15. Jeon SJ, Son KH, Kim YS, Choi YH, Kim HP: Inhibition of prostaglandin and nitric oxide production in lipopolysaccharide- treated RAW 264.7 cells by tanshinones from the roots of Salvia miltiorrhiza bunge. Arch Pharm Res 31;758-763, 2008. https://doi.org/10.1007/s12272-001-1223-4
  16. Kim SY, Moon TC, Chang HW, Son KH, Kang SS, Kim HP: Effects of tanshinone I isolated from Salvia miltiorrhiza bunge on arachidonic acid metabolism and in vivo inflammatory responses. Phytotherapy Research 16616-16620, 2002.
  17. Choi H, Kim K: Tanshinones inhibit mast cell degranulation by interfering with IgE receptor-mediated tyrosine phosphorylation of PLCg2 and MAPK. Planta Medica 70178-70180, 2004.
  18. Jang SI, Jeong SI, Kim KJ, Kim HJ, Yu HH, Park R, Kim HM, You YO: Tanshinone IIA from Salvia miltiorrhiza inhibits inducible nitric oxide synthase expression and production of TNF-, IL-1 and IL-6 in activated RAW 264.7 cells. Planta Medica 691057-691059, 2003.
  19. Munoz C, Carlet J, Fitting C, Misset B, Bleriot JP, Cavaillon JM: Dysregulation of in vitro cytokine production by monocytes during sepsis. J Clin Invest 88;1747-1754, 1991. https://doi.org/10.1172/JCI115493
  20. Tauber MG, Moser B: Cytokines and chemokines in meningeal inflammation: biology and clinical implications. Clin Infect Dis 28;1-11, 1999 https://doi.org/10.1086/515079
  21. Hebert CA. Chemokines in disease:biology and clinical research. Totowa (NJ): Humana Press Inc; 1999.
  22. Appay V, Rowland-Jones SL: RANTES: a versatile and controversial chemokine. Trends Immunol 22;83-87, 2001. https://doi.org/10.1016/S1471-4906(00)01812-3
  23. Bazan JF, Bacon KB, Hardiman G, Wang W, Soo K, Rossi D, Greaves DR, Zlotnik A, Schall TJ: A new class of membrane- bound chemokine with a CX3C motif. Nature. 385; 640-644, 1997. https://doi.org/10.1038/385640a0
  24. Matsunawa M, Isozaki T, Odai T, Yajima N, Takeuchi HT, Negishi M, Ide H, Adachi M, Kasama T: Increased serum levels of soluble fractalkine (CX3CL1) correlate with disease activity in rheumatoid vasculitis. Arthritis Rheum 54; 3408-3416, 2006. https://doi.org/10.1002/art.22208
  25. Chen S, Bacon KB, Li L, Garcia GE, Xia Y, Lo D, Thompson DA, Siani MA, Yamamoto T, Harrison JK, Feng L: In vivo inhibition of CC and CX3C chemokine-induced leukocyte infiltration and attenuation of glomerulonephritis in Wistar- Kyoto (WKY) rats by vMIP-II. J Exp Med 188;193-198, 1998. https://doi.org/10.1084/jem.188.1.193
  26. Schlondorff D, Nelson PJ, Luckow B, Banas B: Chemokines and renal disease. Kidney Int 51;610-621, 1997. https://doi.org/10.1038/ki.1997.90
  27. Schall TJ, Bacon KB: Chemokines, leukocyte trafficking, and inflammation. Curr Opin Immunol 6;865-873, 1994. https://doi.org/10.1016/0952-7915(94)90006-X
  28. Rollins BJ, Yoshimura T, Leonard EJ, Pober JS: Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP-1/JE. Am J Pathol 136; 1229-1233, 1990.
  29. Choy EH, Panayi GS: Cytokine pathways and joint inflammation in rheumatoid arthritis. N Engl J Med 344; 907-916, 2001. https://doi.org/10.1056/NEJM200103223441207
  30. Besedovsky HO, del Rey A: Immune-neuro-endocrine interactions: facts and hypotheses. Endocr Rev 17;64-102, 1996. https://doi.org/10.1210/edrv-17-1-64
  31. Akira S: Toll-like receptor signaling. J Biol Chem 278; 38105-38108, 2003. https://doi.org/10.1074/jbc.R300028200
  32. Morikawa K, Zhang J, Nonaka M, Morikawa S: Modulatory effect of macrolide antibiotics on the Th1- and Th2-type cytokine production. Int J Antimicrob Agents 19;53-59, 2002. https://doi.org/10.1016/S0924-8579(01)00457-5
  33. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL: Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 136;2348-2357, 1986.
  34. Brown MA, Hural J: Functions of IL-4 and control of its expression. Crit Rev Immunol 17;1-32, 1997. https://doi.org/10.1615/CritRevImmunol.v17.i1.10
  35. Underhill DM, Bassetti M, Rudensky A, Aderem A: Dynamic interactions of macrophages with T cells during antigen presentation. J Exp Med 190;1909-1914, 1999. https://doi.org/10.1084/jem.190.12.1909

Cited by

  1. IL-37 (IL-1F7) the Newest Anti-Inflammatory Cytokine Which Suppresses Immune Responses and Inflammation vol.25, pp.1, 2011, https://doi.org/10.1177/039463201202500105
  2. The Salvia miltiorrhiza monomer IH764-3 induces apoptosis of hepatic stellate cells in vivo in a bile duct ligation-induced model of liver fibrosis vol.6, pp.6, 2011, https://doi.org/10.3892/mmr.2012.1076
  3. Phytotherapy in endometriosis: an up-to-date review vol.17, pp.3, 2020, https://doi.org/10.1515/jcim-2019-0084
  4. Fermentation products of Danshen relieved dextran sulfate sodium-induced experimental ulcerative colitis in mice vol.11, pp.1, 2011, https://doi.org/10.1038/s41598-021-94594-7