The Korean Journal of Physiology and Pharmacology

  • 제15권6호
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  • Pages.415-422
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  • 2011
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  • 1226-4512(pISSN)
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  • 2093-3827(eISSN)
대한약리학회 (The Korean Society of Pharmacology)
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Spontaneous Oscillatory Rhythm in Retinal Activities of Two Retinal Degeneration (rd1 and rd10) Mice

  • Goo, Yong-Sook (Department of Physiology, Chungbuk National University School of Medicine) ;
  • Ahn, Kun-No (Department of Physiology, Chungbuk National University School of Medicine) ;
  • Song, Yeong-Jun (Department of Physiology, Chungbuk National University School of Medicine) ;
  • Ahn, Su-Heok (Department of Physics, Chungbuk National University) ;
  • Han, Seung-Kee (Department of Physics, Chungbuk National University) ;
  • Ryu, Sang-Baek (Department of Biomedical Engineering, College of Health Science, Yonsei University) ;
  • Kim, Kyung-Hwan (Department of Biomedical Engineering, College of Health Science, Yonsei University)
  • 투고 : 2011.11.02
  • 심사 : 2011.12.09
  • 발행 : 2011.12.30
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초록

Previously, we reported that besides retinal ganglion cell (RGC) spike, there is ~10 Hz oscillatory rhythmic activity in local field potential (LFP) in retinal degeneration model, rd1 mice. The more recently identified rd10 mice have a later onset and slower rate of photoreceptor degeneration than the rd1 mice, providing more therapeutic potential. In this study, before adapting rd10 mice as a new animal model for our electrical stimulation study, we investigated electrical characteristics of rd10 mice. From the raw waveform of recording using $8{\times}8$ microelectrode array (MEA) from in vitro-whole mount retina, RGC spikes and LFP were isolated by using different filter setting. Fourier transform was performed for detection of frequency of bursting RGC spikes and oscillatory field potential (OFP). In rd1 mice, ~10 Hz rhythmic burst of spontaneous RGC spikes is always phase-locked with the OFP and this phase-locking property is preserved regardless of postnatal ages. However, in rd10 mice, there is a strong phase-locking tendency between the spectral peak of bursting RGC spikes (~5 Hz) and the first peak of OFP (~5 Hz) across different age groups. But this phase-locking property is not robust as in rd1 retina, but maintains for a few seconds. Since rd1 and rd10 retina show phase-locking property at different frequency (~10 Hz vs. ~5 Hz), we expect different response patterns to electrical stimulus between rd1 and rd10 retina. Therefore, to extract optimal stimulation parameters in rd10 retina, first we might define selection criteria for responding rd10 ganglion cells to electrical stimulus.

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참고문헌

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