Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Effect of BangPungTongSungSan(BPTSS, 防風通聖散) on acute methamphetamine-induced locomotor activity and c-Fos expression in mice

방풍통성산(防風通聖散)의 급성 메스암페타민에 의한 보행성 행동량과 c-Fos발현에 대한 효과

  • 신지섭 (대구한의대학교 한의과대학 한의학과) ;
  • 장은영 (대구한의대학교 한의과대학 한의학과) ;
  • 김단효 (대구한의대학교 한의과대학 한의학과) ;
  • 김상찬 (대구한의대학교 한의과대학 한의학과) ;
  • 김광중 (대구한의대학교 한의과대학 한의학과) ;
  • 양재하 (대구한의대학교 한의과대학 한의학과)
  • Received : 2011.11.18
  • Accepted : 2011.12.09
  • Published : 2011.12.30
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Abstract

Objectives : The BangPungTongSungSan(BPTSS) has been used as a therapeutic agent for cerebrovascular disease, cerebral hemorrhage, hypertension, diabetes and obesity in oriental medicine. The present study designed to investigate the effect of BPTSS on behavioral change and neuronal activation induced by acute methamphetamine(METH, 2 mg/kg, i.p.) in C57BL/6 mice. Methods : Mice received the oral administration of BPTTS(25, 50 and 100 mg/kg) 1 h prior to saline or METH administration. Locomotor activity was measured for 90 min using videotractking method and c-Fos expression, as marker of neuronal activation, was identified in a separate groups of mice by immunohistochemistry. Results and conclusions : Methamphetamine injection significantly increased locomotor activity and c-Fos expression in the nucleus accumbens and striatum. Interestingly, BPTTS(100 mg/kg) significantly suppressed locomotor activity and c-Fos expression in the nucleus accumbens and striatum by acute exposure to METH. These results suggest that BangPungTongSungSan may be effective in suppressing the reinforcing effect of methamphetamine by modulation neuronal activity.

Keywords

References

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