Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Aldose Reductase Inhibition by Luteolin Derivatives from Parasenecio pseudotaimingasa

  • Kim, Hye-Min (Department of Integrative Plant Science, Chung-Ang University) ;
  • Lee, Jeong-Min (Department of Integrative Plant Science, Chung-Ang University) ;
  • Lee, Ki-Ho (Department of Integrative Plant Science, Chung-Ang University) ;
  • Ahn, Young-Hee (Department of Integrative Plant Science, Chung-Ang University) ;
  • Lee, Sang-Hyun (Department of Integrative Plant Science, Chung-Ang University)
  • Received : 2011.10.06
  • Accepted : 2011.12.10
  • Published : 2011.12.30
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Abstract

Effects of the extract and fractions from Parasenecio pseudotaimingasa on rat lens aldose reductase (AR) inhibition have been investigated. Among them, the n-BuOH fraction was exhibited good inhibitory potencies ($IC_{50}$ value 1.42 ${\mu}g/ml$). Phytochemical constituents were isolated from the n-BuOH fraction by open column chromatography. Their structures were elucidated as luteolin-7-O-rutinoside (1) and luteolin-7-Oglucoside (2) on the basis of spectroscopic analysis. Compounds 1 and 2 exhibited strong AR inhibitory activity, with $IC_{50}$ values of 2.37 and 1.05 ${\mu}M$, respectively. This is the first report on the isolation of compounds 1 and 2 from P. pseudotaimingasa. These results suggest that P. pseudotaimingasa could be a useful material in the development of a novel AR inhibitory agent against diabetic complications.

Keywords

References

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