Natural Product Sciences

  • 제17권4호
  • /
  • Pages.309-314
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  • 2011
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  • 1226-3907(pISSN)
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  • 2288-9027(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

Toxicological and Pharmacological Studies of New Coumarin and Furocoumarin Derivatives in Albino rats

  • Shabrawy, Osama A. El (Department of Pharmacology, National Research Centre) ;
  • Batran, Seham Abd El Sattar El (Department of Pharmacology, National Research Centre) ;
  • Mahran, Mohamed Refat H. (Department of Organometallic, National Research Centre) ;
  • Ibrahim, Nabila M. (Department of Organometalloid Chemistry, National Research Centre)
  • 투고 : 2011.05.23
  • 심사 : 2011.11.23
  • 발행 : 2011.12.30
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초록

Synthetic coumarin and furocoumarin derivatives were evaluated for anticoagulant activity and the effect on liver and kidney function. It was found that all of the compounds under investigation proved to be neither toxic nor lethal up to 500 mg/100 g body weight as a single dose for 24 hrs. All tested compounds showed a significant increase in prothrombin time (PT) in the acute model but failed to show a significant action in the chronic model. Furthermore, all tested compounds revealed a significant increase in activated partial thromboplastin time (APTT) as compared to control value in both acute and chronic model. Also, all tested compounds did not cause any significant changes on liver and kidney functions in rats.

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참고문헌

  1. Bergendorff, O., Dekermendjian, K., Nielsen, M., Shen, R., Witt, R., Ai, J., and Sterner, O., Furanocoumarins with affinity to brain benzodiazepine receptors in vitro. Phytochemistry 44, 1121-1124 (1997). https://doi.org/10.1016/S0031-9422(96)00703-0
  2. Burtis, C.A. and Ashwood, E.R., Tietz Fundamentals of Clinical Chemistry, Fourth Edition Vol. I, W.B. Saunders Company, 1996.
  3. Caen, J., Larrieu, M.J., and Samama, M., Methode dExploration et Diagnostic Pratige.L'expansion scientifique, Pairs, 1975.
  4. Cremlyn, R.J., Swinburne, F.J., Bloy, J.G., Pathak, K. and Schode, O.O., Pesticides; preparation and mode of action. John Wiley, Chichester, 1978.
  5. Dacie, J.V. and Leucie, S.M., Practical Hematology, Seventh Edition, Churchill Living Stone, Edinburgh, 1991.
  6. Fahmy, I. and Abu, Shady, H., The isolation and properties ammoidin, ammidin and majudin and their effect in the tratment of leukoderma, Quart J pharm and Pharmacol. 21, 499-503 (1948).
  7. Feuer, G., Biological action of coumarin, Prog. Med. Chem. 10, 85 (1973).
  8. Gasparro, F.P., Liao, B., Foley, P.J., Wang, M.X., and Meniff, J.M., Psoralen phytochemotherapy, clinical efficacy, and photometagenicity the role of molecular epidemiolog in minimizing risks, Environ, Mol. Mutagen 31, 105-112 (1998). https://doi.org/10.1002/(SICI)1098-2280(1998)31:2<105::AID-EM2>3.0.CO;2-L
  9. Goodman and Gillman's, The Pharmacological Basis of Therapeutics, Eighth Edition Vol. II, 1991.
  10. He, K., Iyer, K.R., Hayes, R.N., Sinz, M.W., Woolf, T.F., and Hollenberg, P.F., In activation of cytochrome P450 by bergamottin, a component of grape fruite Juice. Chem. Res. Toxicol. 11, 252 (1998). https://doi.org/10.1021/tx970192k
  11. Heneghan, C., Alonso-Coello, P., Garcia-Alamino, J.M., Perera, R., Meats, E., Glasziou, P., Self-monitoring of oral anticoagulation: a systematic review and meta-analysis, Lancet 367, 404-411 (2006). https://doi.org/10.1016/S0140-6736(06)68139-7
  12. Hermodson, M.A., Barker, W.M., and Link, K.P., Studies on the 4-hydroxycoumarins. Synthesis of the metabolities and some other derivatives of warfarin, J. Med. Chem. 14, 167-169 (1971). https://doi.org/10.1021/jm00284a022
  13. Horder, M. and Rej, R., Methods of Enzymatic Analysis, Third Edition. Vol. 3, Weinhiem, Germany 1983.
  14. Karber, G., Bietrag, Zur, and Kollectiven, Behandlung, Pharmakolgischem reinhen versuche, Arch. Exp. Pathol. Pharamakol, 162, 480-482 (1931) https://doi.org/10.1007/BF01863914
  15. Kimura, Y. and Okuda, H., Histamine-release effectors from Angelica dahurica var. dahurica root. J. Nat. Prod. 60, 249-251 (1997). https://doi.org/10.1021/np960407a
  16. Luftl, M., Degitz, K., Plewig, G., and Rocken, M., Psoralen bath plus UV-A therapy Possibilities and limitations. Arch. Dermatol. 133, 1597-1603 (1997). https://doi.org/10.1001/archderm.1997.03890480123023
  17. Manderfeld, M.M., Schafer, H.W., Davidson, P.M., and Zottola, E.A., Isolation and identification of antimicrobial furocoumarins from parsley. J. Food Prot. 60, 72-77 (1997). https://doi.org/10.4315/0362-028X-60.1.72
  18. Murray, R.D.H., Mendez, J., and Brown, S.A., The Natural Coumarins, Occurrence, Chemistry and Biochemistry, Vol. I & II John Wiley and Sons, Ltd. (Awiley-Inter science Publications, Printed by Page Bres-Nerwich, LTd.), 1982.
  19. Mustafa, A., Furopyrans and Furopyrones, Interscience Publishers (Adivision of John Wiley and Sons) London, 1967.
  20. Nishino, H., Okuyama, T., Takata, M., Shibata, S., Tokuda, H., Takayasu, J., Hasegawa, T., Nishino, A., Ueyama, H., and Iwashima, A., Studies on the antitumor-promoting activity of naturally occuring substance. IV, Pd-II [C+] anomaling (+) praeruptorin B], aseselin-type coumarin, inhibits the promotion of skin tumor fomation by 12-0-tetradecanoyl porbol-13-acetate in 7,12-dimethylbenz [a] anthracene-initiated mice, Carcinogenesis 11, 1557-1561 (1990). https://doi.org/10.1093/carcin/11.9.1557
  21. Obaseki, A.O. and Porter, W.R.J., 4-Hydroxycoumarin comprises the structural nucleus of many natural products, drugs and pesticides. Heterocyclic Chem. 19, 385-390 (1982). https://doi.org/10.1002/jhet.5570190234
  22. Occhiuto, F. and Circosta, C., Bergamottine, a furocoumarin isolated from bergamot oil. Phytother Res. 11, 450-453 (1997). https://doi.org/10.1002/(SICI)1099-1573(199709)11:6<450::AID-PTR127>3.0.CO;2-S
  23. Okuyama, T., Takata, M., Nishino, H., Nishino, A., Takayasu, J., and Iwashima, A., Studies on the antitumor-promoting activity of naturally occuring substances. II Inhibition of tumor-promoter-ehanced phosopholipid metabolism by umbelliferous materials. Chem. Pharm. Bull. (Tokyo), 38, 1084-1086 (1990). https://doi.org/10.1248/cpb.38.1084
  24. Perkins, B.D., Wensel, T.G., Vasquez, K.M., and Wilson, J.H., Psoralen photo-cross-linking by triplex-forming oligonucleotides at multiple sites in the human rhodopsin gene, Biochemistry, 38, 12850-12859. (1999). https://doi.org/10.1021/bi9902743
  25. Rodgers, G.M., Wintrobe's Clinical Hematology; Tenth Edition Vol. 2 Williams & Wilkins, Maryland, MSA, 1999.
  26. Sethna, S.M. and Shah, N.M., Preparation of organocarbonyl coumarins, Chem. Rev. 31, 1 (1945).
  27. Shroeder, C.H. and Link, K.P., US Pat. 2, 765, 321, 1956; Merck Index, Nr. 9852, 1982.
  28. Spencer, K., Analytical reviews in clinical biochemistry: the estimation of creatinine, Ann. Clin. Biochem. 23, 1-25 (1986). https://doi.org/10.1177/000456328602300101
  29. Stephen, F.B., Dodds, W.J. and Van-Vleet, F., Plasmo coagulation factor abnormalities in dogs with naturally occuring hepatic disease, Am. J. Vet. Res. 44, 2336-2340 (1983).
  30. Suttie J.W., The biochemical basis of warfarin therapy, Adv. Exp. Med. Biol. 214, 3-16 (1987).
  31. Wu, J.Z., Tetrazolium-based colorimetric (MTT) and its application in chemosenstivity testing of antitumors chinese medicine, Zhonghua Kou Qiang Yi Xue Za Zhi 27, 373-375 (1992).
  32. Yamahara, J., Kozuka, M., Sawada, T., Fujimura, H., Nakano, K., Tomjmatsu, T., and Nohara, T., Biologically active principle of crude drugs. Anti-allargic principles in "Cnidii monnieri". Chem. Pharm. Bull. 33, 1676-1680 (1985). https://doi.org/10.1248/cpb.33.1676
  33. Yakout, E.M.A., Mahran M.R., Ghoneim, K.M., Shabana, R., and Ibrahim, N.M., Reaction of 4-Hydroxybergapten and 4-Hydroxyisopimpinellin with $\alpha,\beta$-Unsaturated carbonyl compounds. synthesis of new furocoumarin derivatives of expected anticoagulant activity. Bull. Fac. Pharm. Cairo Univ., 32, 51-58 (1998).
  34. Yakout, E.M.A., Ibrahim, N.M., Ghoneim, K.H.M., and Mahran, M.R., The Reaction of 4-Hydroxycoumarin and 4-Hydroxyfuro-coumarns with $\alpha,\beta$-Unsaturated Nitriles. Mass Spcetrometry of the new apyrano-a-pyrane derivatives. J. Chem. Res. 5, 652-653 (1999).