Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Anti-inflammatory and Antinociceptive Properties of the Ethanolic Extract of Gleditsia sinensis and its Sub-fractions

조각자 에탄올 추출물 및 그 분획의 항염증 및 진통효능

  • Yoon, Byung-Hoon (Department of Life and Nanopharmaceutical Science, Kyung Hee University) ;
  • Park, Se-Jin (Department of Life and Nanopharmaceutical Science, Kyung Hee University) ;
  • Shin, Bum-Young (Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Jung, Jae-Bark (Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Shin, Ji-Sun (Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Jang, Young-Pyo (Department of Life and Nanopharmaceutical Science, Kyung Hee University) ;
  • Lee, Kyung-Tae (Department of Life and Nanopharmaceutical Science, Kyung Hee University) ;
  • Ryu, Jong-Hoon (Department of Life and Nanopharmaceutical Science, Kyung Hee University)
  • 윤병훈 (경희대학교 나노의약생명과학과) ;
  • 박세진 (경희대학교 나노의약생명과학과) ;
  • 신범영 (경희대학교 기초약학과) ;
  • 정재박 (경희대학교 기초약학과) ;
  • 신지선 (경희대학교 기초약학과) ;
  • 장영표 (경희대학교 나노의약생명과학과) ;
  • 이경태 (경희대학교 나노의약생명과학과) ;
  • 류종훈 (경희대학교 나노의약생명과학과)
  • Received : 2011.08.31
  • Accepted : 2011.11.10
  • Published : 2011.12.31
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Abstract

Traditionally, the thorns of Gleditsia sinensis LAM. (GS) have been used for the treatment of various types of cancer and heart, skin, vascular and inflammatory diseases. However, there have been no reports on the antinociceptive or antiinflammatory properties of the thorn of GS. The present study was carried out to evaluate the anti-inflammatory and antinociceptive effects of the ethanolic extract of GS (EEGS) and its sub-fractions. The administration of EEGS (500 mg/kg) or its butanolic fraction (50 and 100 mg/kg) reduced the frequency of the acetic acid-induced writhing reflex in mice. In addition, the administration of the butanolic fraction of EEGS (50 and 100 mg/kg) prolonged the latency of reaction at the hot plate in mice. The butanolic fraction of EEGS also inhibited lipopolysaccharide-induced nitric oxide, prostaglandin $E_2$, and tumor necrosis factor-$\acute{a}$ production in the RAW 264.7 cell line. These results suggest that EEGS has anti-inflammatory and analgesic properties and is a potential therapeutic for inflammation and nociception.

Keywords

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