Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Inhibitors of Adipogenesis in 3T3-L1 Cells Isolated from Wheat Bran

밀겨 유래의 3T3-L1 세포 지방생성 억제물질

  • Jeong, Won-Sik (Natural Products Research Institute, Gyeonggi Institute of Science & Technology Promotion) ;
  • Hong, Seong-Su (Natural Products Research Institute, Gyeonggi Institute of Science & Technology Promotion) ;
  • Lee, Jung-A (Natural Products Research Institute, Gyeonggi Institute of Science & Technology Promotion) ;
  • Ahn, Eun-Kyung (Natural Products Research Institute, Gyeonggi Institute of Science & Technology Promotion) ;
  • Oh, Joa-Sub (Natural Products Research Institute, Gyeonggi Institute of Science & Technology Promotion)
  • 정원식 (경기과학기술진흥원 천연물신약연구소) ;
  • 홍성수 (경기과학기술진흥원 천연물신약연구소) ;
  • 이정아 (경기과학기술진흥원 천연물신약연구소) ;
  • 안은경 (경기과학기술진흥원 천연물신약연구소) ;
  • 오좌섭 (경기과학기술진흥원 천연물신약연구소)
  • Received : 2011.10.31
  • Accepted : 2011.12.23
  • Published : 2011.12.31
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Abstract

As a part of our ongoing program on finding biologically active components from natural source we found three known constituents from the EtOH extract of the wheat bran. The known compounds were identified as tachioside (1), pinellic acid (2) and tryptophan (3). The structure and relative stereochemistry were determined from MS, 1D and extensive 2D NMR techniques as well as by comparison of their data with the published values. All isolates were tested their inhibitory effects on the adipogenesis in 3T3-L1 cells. The effect of compounds from wheat bran on 3T3-L1 adipocyte differentiation were measured by Oil Red O staining. These results demonstrate that tachioside (1) and pinellic acid (2) decreased lipid content in 3T3-L1 adipocytes by inhibiting lipogenesis. These compounds had shown antiobesity activities.

Keywords

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