Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effects of Minerals Added to Medicinal Plant Extracts on Alcohol-Induced Oxidative Stress and Alcohol Metabolism in Rats

약용식물 추출물이 첨가된 미네랄이 알코올에 의한 산화적 스트레스 및 숙취해소에 미치는 효과

  • Lee, Seok-Jun (Dept. of Pharmaceutical Engineering, College of Medical & Life Science, Silla University) ;
  • Kim, Andre (Dept. of Pharmaceutical Engineering, College of Medical & Life Science, Silla University) ;
  • Lee, Jae-Hwa (Dept. of Pharmaceutical Engineering, College of Medical & Life Science, Silla University) ;
  • Kim, Mee-Hee (Daehan Deepseawater Co., LTD) ;
  • Lee, Bong-Sang (Daehan Deepseawater Co., LTD) ;
  • Jee, Young-Taek (Daehan Deepseawater Co., LTD) ;
  • Bin, Jae-Hun (Water Quality Institute) ;
  • Ha, Jong-Myung (Dept. of Pharmaceutical Engineering, College of Medical & Life Science, Silla University)
  • 이석준 (신라대학교 의생명과학대학 제약공학과) ;
  • 김안드레 (신라대학교 의생명과학대학 제약공학과) ;
  • 이재화 (신라대학교 의생명과학대학 제약공학과) ;
  • 김미희 ((주)대한심층수) ;
  • 이봉상 ((주)대한심층수) ;
  • 지영택 ((주)대한심층수) ;
  • 빈재훈 (부산광역시 상수도사업본부) ;
  • 하종명 (신라대학교 의생명과학대학 제약공학과)
  • Received : 2010.11.29
  • Accepted : 2011.02.07
  • Published : 2011.03.31
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Abstract

This study investigates the effects of a hangover beverage (MIX) that contains minerals (highly-salty mineral water, HSMW) and several medicinal plant extracts, on antioxidant and alcohol-metabolizing enzymes in alcohol administered Sprague-Dawley rats. HSMW is pumped from below the sedimentary rock layer of Dadaepo, Busan, South Korea, which is 1,050 m below the land surface; it tastes salty, like sea water. In terms of medicinal plant extracts, the total phenolic and flavonoid contents of Rubus coreanus and Cornus officinalis were measured as being significantly higher than those in Curcuma longa. The results suggest that treatment with MIX significantly increases superoxide dismutase (SOD) activity and DPPH radical scavenging activity. In the 10% HSMW-, for MIX- and company product (CP)-treated groups, the concentration of blood alcohol was significantly reduced 1~5 hr after alcohol loading, compared to that in the control group. In hepatic alcohol-metabolizing enzyme activities, alcohol dehydrogenase (ADH) activity was found to be higher in the MIX- and CP-treated groups than in controls, whereas acetaldehyde dehydrogenase (ALDH) activity was significantly higher in the CP-treated groups than other groups. This study concludes, therefore, that MIX (HSMW) minerals, like as Zn, Ca, Mg, Mn, and others stimulate alcohol-metabolizing enzymes, while the antioxidants of plant extracts prevent the damage otherwise incurred by alcohol toxicity. These results suggest that the hangover beverage (MIX) alleviates alcohol hangover symptoms by stimulating activities related to hepatic alcohol-metabolizing enzymes and antioxidant effects.

항산화 작용에 효과가 있다고 알려진 복분자, 울금, 산수유 추출물과 알코올분해 효소 작용을 촉진시킬 수 있는 천연미네랄수(HSMW)를 첨가한 복합물(MIX)이 항산화 활성 및 알코올을 투여한 쥐의 혈중 알코올 농도와 체내 알코올 대사에 어떤 영향을 미치는지 검토하였다. 약용식물 추출물에서 복분자, 산수유의 총 페놀 및 플라보노이드 함량이 유의적으로 높게 정량되었으며, DPPH radical scavenging과 SOD 활성에서는 MIX가 유의적으로 높아 항산화 효과를 나타내었다. 혈중 알코올 농도를 측정한 결과에서 10% HSMW 투여군이 대조군의 농도보다 유의적인 차이를 나타내었다. MIX와 CP 투여군은 모든 시간 경과 후에 대조군의 농도보다 유의적인 차이를 나타내었으며 두 군 간의 유의적인 차이는 나타나지 않았지만 고농도가 저농도에 비해 5~10% 더 감소하였다. MIX와 CP 투여군의 간 균질액의 ADH 활성은 정상군에 비해 유의적인 차이를 볼 수 없었으며, ALDH 활성은 MIX와 CP 투여군이 유의적으로 높았다. 또한 혈청 중 간 기능 지표 효소인 GOT, GPT 활성은 MIX 투여군이 정상군과 비슷한 활성을 보여 간 손상이 적었음을 알 수 있었다. 따라서 MIX에 함유된 미네랄수(HSMW)인 Zn, Ca, Mg, Mn 등이 알코올 분해 효소 활성을 조절함과 동시에 약용식물 추출물이 항산화 작용을 하여 음주로 인해 발생하는 숙취 증상과 산화적 스트레스를 효과적으로 완화시킬 수 있으며, 체내 알코올 대사에 직 간접적으로 작용해 간 기능의 저하를 방지하는 기능성 숙취 음료로 사용될 것이라고 사료되어진다.

Keywords

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