The Korean Journal of Medicine

  • 제81권3호
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  • Pages.412-415
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  • 2011
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  • 1738-9364(pISSN)
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  • 2289-0769(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
권호 표지

클라인펠터 증후군(Klinefelter's Syndrome)에서 동반된 류마티스관절염 1예

A Case of Rheumatoid Arthritis Associated with Klinefelter's Syndrome

  • 서미령 (가천의과대학교 길병원 내과학교실 류마티스내과) ;
  • 조현정 (가천의과대학교 길병원 내과학교실 류마티스내과) ;
  • 최효진 (가천의과대학교 길병원 내과학교실 류마티스내과) ;
  • 백한주 (가천의과대학교 길병원 내과학교실 류마티스내과) ;
  • 안정열 (가천의과대학교 길병원 진단검사의과학교실)
  • Seo, Mi-Ryoung (Department of Internal Medicine, Division of Rheumatology, Gil Medical Center, Gachon University of Medicine and Science) ;
  • Cho, Hyun-Jung (Department of Internal Medicine, Division of Rheumatology, Gil Medical Center, Gachon University of Medicine and Science) ;
  • Choi, Hyo-Jin (Department of Internal Medicine, Division of Rheumatology, Gil Medical Center, Gachon University of Medicine and Science) ;
  • Baek, Han-Joo (Department of Internal Medicine, Division of Rheumatology, Gil Medical Center, Gachon University of Medicine and Science) ;
  • Ahn, Jeong-Yeal (Department of Laboratory Medicine, Gil Medical Center, Gachon University of Medicine and Science)
  • 발행 : 2011.09.01
⟨ 이전 논문 다음 논문 ⟩

초록

저자 등은 29세 남자에서 드문 활동성 류마티스관절염이 클라인펠터 증후군에 동반하여 발생한 국내 첫 증례를 경험하였다. 환자는 클라인펠터 증후군의 치료를 위해 지속적인 테스토스테론의 보충 요법을 했지만, 혈청 안드로겐 수치는 정상보다 낮았다. 환자의 성호르몬 불균형 상태가 류마티스 관절염의 발병과 경과에 영향을 미쳤을 것으로 추정된다.

Klinefelter's syndrome is a disorder of sexual differentiation in males, characterized by the presence of two or more X-chromosomes, hypogonadism, and lack of secondary sexual characteristics. The association between Klinefelter's syndrome and systemic lupus erythematous has been described, while cases of rheumatoid arthritis associated with Klinefelter's syndrome are rare. We report the first Korean case: a 29-year-old man with Klinefelter's syndrome who developed rheumatoid arthritis. The sex hormone imbalance might have influenced the onset and course of his disease.

키워드

참고문헌

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