Journal of dental hygiene science (치위생과학회지)

The Korean Society of Dental Hygiene Science (한국치위생과학회)
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An Evaluation of Antibacterial Titanium Surface For Dental Implant

치과용 임플란트 적용을 위한 항균력을 가진 티타늄 표면의 평가

  • Kang, Min-Kyung (BK21, Department and Research Institute of Dental Biomaterials and Bioengineering, Research Center for Orofacial Hard Tissue Regeneration, College of Dentistry, Yonsei University) ;
  • Moon, Seung-Kyun (BK21, Department and Research Institute of Dental Biomaterials and Bioengineering, Research Center for Orofacial Hard Tissue Regeneration, College of Dentistry, Yonsei University) ;
  • Kim, Kyoung-Nam (BK21, Department and Research Institute of Dental Biomaterials and Bioengineering, Research Center for Orofacial Hard Tissue Regeneration, College of Dentistry, Yonsei University)
  • 강민경 (BK21, 연세대학교 치과대학 치과생체재료공학교실 및 연구소, 연세대학교 치과대학 구강악안면 경조직재생 연구센터) ;
  • 문승균 (BK21, 연세대학교 치과대학 치과생체재료공학교실 및 연구소, 연세대학교 치과대학 구강악안면 경조직재생 연구센터) ;
  • 김경남 (BK21, 연세대학교 치과대학 치과생체재료공학교실 및 연구소, 연세대학교 치과대학 구강악안면 경조직재생 연구센터)
  • Received : 2011.08.08
  • Accepted : 2011.10.15
  • Published : 2011.10.31
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Abstract

The aim of this study was to evaluate antibacterial effect of Cl coated titanium. To coat the Cl on the titanium, first, the titanium was modified by blasting treatment with hydroxyapatite and alumina powder. Anodization process was completed using electrolyte solution of 0.04 M ${\beta}$-glycerol phosphate disodium salt n-hydrate, 0.4 M calcium acetate n-hydrate and 1 M NaCl on the condition of 250 voltages for 3 min. Surface morphology and elements' observation were performed with scanning electron microscopy and energy dispersive spectroscopy and surface profiler was used to analyze the surface roughness. Antibacterial effect was evaluated by film adhesion method. The anodized titanium after blasting showed dimpled surface contained the Cl. Surface average roughness of these surfaces had significantly higher compared to polished titanium. Result of antibacterial test showed that anodized titanium after blasting had an enhanced antibacterial effect compared to the polished titanium. Therefore, these results suggested that titanium contained Cl by anodization after blasting had a rough surface as well as antibacterial effect.

본 연구의 목적은 표면 거칠기를 증가시키기 위하여 알루미나와 하이드록시아파타이트를 이용하여 각각 블라스팅 처리한 뒤 염화나트륨을 전해액 내에 섞어 양극산화 방법을 이용하여 염소가 함유된 표면을 만들고 항균력을 평가하는데 있다. 그리고 표면 특성과 항균력을 평가하여 다음과 같은 결과를 얻었다. 1. SEM 표면 관찰에서는 블라스팅 처리 후 양극산화한 결과 실험군 2와 3에서 연마처리한 실험군 1에 비해 거친 요철구조를 관찰할 수 있었다. 2. EDS 조성분석 결과 실험군 2에서는 칼슘, 인, 염소 성분과 더불어 알루미늄이 관찰된 반면, 실험군 3에서는 칼슘, 인과 염소 성분만을 관찰할 수 있었다. 3. 표면 거칠기 분석 결과 평균 표면 거칠기의 값이 실험군 2, 실험군 3, 실험군 1순으로 작았으며, 실험군 2와 3 간에는 유의한 차이가 없었다(p>0.05). 4. 항균력 평가 결과 실험군 2가 가장 적은 세균수를 보여 우수한 항균력을 보였으나 이는 실험군 3과 유의한 차이가 없었다(p>0.05). 알루미나와 하이드록시아파타이트를 이용하여 각각 블라스팅 처리한 뒤 염화나트륨을 전해액 내에 섞어 양극산화 방법을 이용하여 염소가 함유된 표면을 만들 수 있었으며, 그 결과 연마처리한 시편에 비해 높은 표면 거칠기와 우수한 항균력을 보였다. 그러나 그 재료의 효과와 안정성을 입증하기 위해서는 추가적인 in vitro와 in vivo 실험이 수행되어야겠다.

Keywords

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