This study covers the optimum design of the 5-axis machine tool. In addition, the intelligent control secures structural stability through the optimum design of the structure of the 5-axis machine center, main spindle, and the tilting index table. The big requirement, like above, ultimately leads to speed-up operation. And this is inevitable to understand the vibration phenomenon and its related mechanical phenomenon in terms of productivity and its accuracy. In general, the productivity is correlated with the operation speed and it has become bigger by its vibration scale and the operation speed so far. Vibration phenomenon and its heat-transformation of the machine is naturally occurred during the operation. If these entire machinery phenomenons are interpreted through the constructive understanding and the interpretation of the naturally produced vibration and heat-transformation, it would be very useful to improve the rapidity and its stability of the machine operation indeed. In this dissertation, the problems of structure through heating, stability, dynamic aspect and safety about intelligent 5-wheel machine tool are discovered to examine. All these discoveries are applied to the structure in order to enhance the density of it. It aims to improve the stability.