The Korean Journal of Medicine

  • 제81권2호
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  • Pages.174-184
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  • 2011
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  • 1738-9364(pISSN)
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  • 2289-0769(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
권호 표지

당뇨병성 위 마비

Diabetic Gastroparesis

  • 권중구 (대구가톨릭대학교 의과대학 내과학교실)
  • Kwon, Joong-Goo (Department of Internal Medicine, Catholic University of Daegu School of Medicine)
  • 발행 : 2011.08.01
⟨ 이전 논문 다음 논문 ⟩

초록

Diabetic gastroparesis is a complication that often occurs in long-standing diabetic patients and it is characterized by delayed gastric emptying and upper gastrointestinal symptoms. The pathophysiology of gastroparesis is complex and poorly understood but substantial advances in knowledge about it have been gained from experimental studies of gastric tissue in animal models and humans with diabetes. Several abnormalities in diabetes might result in gastroparesis, including autonomic neuropathy, enteric neuropathy, abnormalities of interstitial cells of Cajal and smooth muscle cells, acute hyperglycemia and psychological dysfunction. Scintigraphic measurement of solid emptying is regarded as gold standard diagnostic technique for comparison of newer diagnostic modalities such as ultrasound, breath test and MRI. The available therapeutic options include dietary modification, optimization of glycemia, pharmacological interventions, endoscopic treatment, and gastric electrical stimulation. The efficacy of current treatment remains suboptimal and the search for more specific and effective treatments will likely be needed.

키워드

참고문헌

  1. Parkman HP, Hasler WL, Fisher RS. American Gastroenterological Association technical review on the diagnosis and treatment of gastroparesis. Gastroenterology 2004;127:1592-1622. https://doi.org/10.1053/j.gastro.2004.09.055
  2. Kassander P. Asymptomatic gastric retention in diabetics (gastroparesis diabeticorum). Ann Intern Med 1958;48:797-812. https://doi.org/10.7326/0003-4819-48-4-797
  3. Camilleri M. Clinical practice: diabetic gastroparesis. N Engl J Med 2007;356:820-829. https://doi.org/10.1056/NEJMcp062614
  4. Bell RA, Jones-Vessey K, Summerson JH. Hospitalizations and outcomes for diabetic gastroparesis in North Carolina. South Med J 2002;95:1297-1299.
  5. Park MI, Camilleri M. Gastroparesis: clinical update. Am J Gastroenterol 2006;101:1129-1139. https://doi.org/10.1111/j.1572-0241.2006.00640.x
  6. Jung HK, Choung RS, Locke GR 3rd, et al. The incidence, prevalence, and outcomes of patients with gastroparesis in Olmsted County, Minnesota, from 1996 to 2006. Gastroenterology 2009;136:1225-1233. https://doi.org/10.1053/j.gastro.2008.12.047
  7. Maleki D, Locke GR 3rd, Camilleri M, et al. Gastrointestinal tract symptoms among persons with diabetes mellitus in the community. Arch Intern Med 2000;160:2808-2816. https://doi.org/10.1001/archinte.160.18.2808
  8. Bytzer P, Talley NJ, Leemon M, Young LJ, Jones MP, Horowitz M. Prevalence of gastrointestinal symptoms associated with diabetes mellitus: a population-based survey of 15,000 adults. Arch Intern Med 2001;161:1989-1996. https://doi.org/10.1001/archinte.161.16.1989
  9. Kong MF, Horowitz M, Jones KL, Wishart JM, Harding PE. Natural history of diabetic gastroparesis. Diabetes Care 1999;22:503-507. https://doi.org/10.2337/diacare.22.3.503
  10. Nowak TV, Johnson CP, Kalbfleisch JH, et al. Highly variable gastric emptying in patients with insulin dependent diabetes mellitus. Gut 1995;37:23-29. https://doi.org/10.1136/gut.37.1.23
  11. Horowitz M, Harding PE, Maddox AF, et al. Gastric and oesophageal emptying in patients with type 2 (non-insulindependent) diabetes mellitus. Diabetologia 1989;32:151-159. https://doi.org/10.1007/BF00265086
  12. Camilleri M, Bharucha AE, Farrugia G. Epidemiology, mechanisms, and management of diabetic gastroparesis. Clin Gastroenterol Hepatol 2011;9:5-12; quiz e7. https://doi.org/10.1016/j.cgh.2010.09.022
  13. Choung RS, Locke GR 3rd, Schleck C, Zinsmeister A, Talley NJ. Cumulative incidence of gastroparesis in people with type 1 and 2 diabetes in the general population. Am J Gastroenterol 2008;103(Suppl):S309.
  14. Jones KL, Russo A, Berry MK, Stevens JE, Wishart JM, Horowitz M. A longitudinal study of gastric emptying and upper gastrointestinal symptoms in patients with diabetes mellitus. Am J Med 2002;113:449-455. https://doi.org/10.1016/S0002-9343(02)01228-7
  15. Samsom M, Roelofs JM, Akkermans LM, van Berge Henegouwen GP, Smout AJ. Proximal gastric motor activity in response to a liquid meal in type I diabetes mellitus with autonomic neuropathy. Dig Dis Sci 1998;43:491-496. https://doi.org/10.1023/A:1018894520557
  16. Ishiguchi T, Nakajima M, Sone H, Tada H, Kumagai AK, Takahashi T. Gastric distension-induced pyloric relaxation: central nervous system regulation and effects of acute hyperglycaemia in the rat. J Physiol 2001;533:801-813. https://doi.org/10.1111/j.1469-7793.2001.t01-1-00801.x
  17. Schwartz TW. Pancreatic polypeptide: a hormone under vagal control. Gastroenterology 1983;85:1411-1425.
  18. Buysschaert M, Donckier J, Dive A, Ketelslegers JM, Lambert AE. Gastric acid and pancreatic polypeptide responses to sham feeding are impaired in diabetic subjects with autonomic neuropathy. Diabetes 1985;34:1181-1185. https://doi.org/10.2337/diabetes.34.11.1181
  19. Guy RJ, Dawson JL, Garrett JR, et al. Diabetic gastroparesis from autonomic neuropathy: surgical considerations and changes in vagus nerve morphology. J Neurol Neurosurg Psychiatry 1984;47:686-691. https://doi.org/10.1136/jnnp.47.7.686
  20. Shah V, Lyford G, Gores G, Farrugia G. Nitric oxide in gastrointestinal health and disease. Gastroenterology 2004;126:903-913. https://doi.org/10.1053/j.gastro.2003.11.046
  21. Takahashi T, Nakamura K, Itoh H, Sima AA, Owyang C. Impaired expression of nitric oxide synthase in the gastric myenteric plexus of spontaneously diabetic rats. Gastroenterology 1997;113:1535-1544. https://doi.org/10.1053/gast.1997.v113.pm9352855
  22. Spangeus A, Forsgren S, el-Salhy M. Does diabetic state affect co-localization of peptide YY and enteroglucagon in colonic endocrine cells? Histol Histopathol 2000;15:37-41.
  23. Spangeus A, El-Salhy M. Myenteric plexus of obese diabetic mice (an animal model of human type 2 diabetes). Histol Histopathol 2001;16:159-165.
  24. Wrzos HF, Cruz A, Polavarapu R, Shearer D, Ouyang A. Nitric oxide synthase (NOS) expression in the myenteric plexus of streptozotocin-diabetic rats. Dig Dis Sci 1997;42:2106-2110. https://doi.org/10.1023/A:1018830820537
  25. Pasricha PJ, Pehlivanov ND, Gomez G, Vittal H, Lurken MS, Farrugia G. Changes in the gastric enteric nervous system and muscle: a case report on two patients with diabetic gastroparesis. BMC Gastroenterol 2008;8:21. https://doi.org/10.1186/1471-230X-8-21
  26. Wang XY, Huizinga JD, Diamond J, Liu LW. Loss of intramuscular and submuscular interstitial cells of Cajal and associated enteric nerves is related to decreased gastric emptying in streptozotocin-induced diabetes. Neurogastroenterol Motil 2009;21:1095-e92. https://doi.org/10.1111/j.1365-2982.2009.01336.x
  27. Ordog T, Takayama I, Cheung WK, Ward SM, Sanders KM. Remodeling of networks of interstitial cells of Cajal in a murine model of diabetic gastroparesis. Diabetes 2000;49:1731-1739. https://doi.org/10.2337/diabetes.49.10.1731
  28. Horvath VJ, Víttal H, Lorincz A, et al. Reduced stem cell factor links smooth myopathy and loss of interstitial cells of cajal in murine diabetic gastroparesis. Gastroenterology 2006;130:759-770. https://doi.org/10.1053/j.gastro.2005.12.027
  29. Iwasaki H, Kajimura M, Osawa S, et al. A deficiency of gastric interstitial cells of Cajal accompanied by decreased expression of neuronal nitric oxide synthase and substance P in patients with type 2 diabetes mellitus. J Gastroenterol 2006;41:1076-1087. https://doi.org/10.1007/s00535-006-1909-8
  30. Forster J, Damjanov I, Lin Z, Sarosiek I, Wetzel P, McCallum RW. Absence of the interstitial cells of Cajal in patients with gastroparesis and correlation with clinical findings. J Gastrointest Surg 2005;9:102-108. https://doi.org/10.1016/j.gassur.2004.10.001
  31. Grover M, Farrugia G, Lurken MS, et al. Cellular changes in diabetic and idiopathic gastroparesis. Gastroenterology 2011;140:1575-1585. e1578. https://doi.org/10.1053/j.gastro.2011.01.046
  32. Choi KM, Gibbons SJ, Roeder JL, et al. Regulation of interstitial cells of Cajal in the mouse gastric body by neuronal nitric oxide. Neurogastroenterol Motil 2007;19:585-595. https://doi.org/10.1111/j.1365-2982.2007.00936.x
  33. Farrugia G. Interstitial cells of Cajal in health and disease. Neurogastroenterol Motil 2008;20(Suppl 1):S54-S63.
  34. Schvarcz E, Palmer M, Aman J, Horowitz M, Stridsberg M, Berne C. Physiological hyperglycemia slows gastric emptying in normal subjects and patients with insulin-dependent diabetes mellitus. Gastroenterology 1997;113:60-66. https://doi.org/10.1016/S0016-5085(97)70080-5
  35. Kashyap P, Farrugia G. Diabetic gastroparesis: what we have learned and had to unlearn in the past 5 years. Gut 2010;59:1716-1726. https://doi.org/10.1136/gut.2009.199703
  36. Jebbink RJ, Samsom M, Bruijs PP, et al. Hyperglycemia induces abnormalities of gastric myoelectrical activity in patients with type I diabetes mellitus. Gastroenterology 1994;107:1390-1397.
  37. Rayner CK, Su YC, Doran SM, Jones KL, Malbert CH, Horowitz M. The stimulation of antral motility by erythromycin is attenuated by hyperglycemia. Am J Gastroenterol 2000;95:2233-2241. https://doi.org/10.1111/j.1572-0241.2000.02250.x
  38. Schvarcz E, Palmér M, Aman J, Lindkvist B, Beckman KW. Hypoglycaemia increases the gastric emptying rate in patients with type 1 diabetes mellitus. Diabet Med 1993;10:660-663. https://doi.org/10.1111/j.1464-5491.1993.tb00141.x
  39. Darwiche G, Almer LO, Bjorgell O, Cederholm C, Nilsson P. Delayed gastric emptying rate in Type 1 diabetics with cardiac autonomic neuropathy. J Diabetes Complications 2001;15:128-134. https://doi.org/10.1016/S1056-8727(00)00143-4
  40. Jones KL, Horowitz M, Carney BI, Wishart JM, Guha S, Green L. Gastric emptying in early noninsulin-dependent diabetes mellitus. J Nucl Med 1996;37:1643-1648.
  41. Lysy J, Israeli E, Strauss-Liviatan N, Goldin E. Relationships between hypoglycaemia and gastric emptying abnormalities in insulin-treated diabetic patients. Neurogastroenterol Motil 2006;18:433-440. https://doi.org/10.1111/j.1365-2982.2006.00800.x
  42. Groop LC, Luzi L, DeFronzo RA, Melander A. Hyperglycaemia and absorption of sulphonylurea drugs. Lancet 1989;2:129-130.
  43. Cherian D, Sachdeva P, Fisher RS, Parkman HP. Abdominal pain is a frequent symptom of gastroparesis. Clin Gastroenterol Hepatol 2010;8:676-681. https://doi.org/10.1016/j.cgh.2010.04.027
  44. Hasler WL, Wilson L, Parkman HP, et al. Importance of abdominal pain as a symptom in gastroparesis: relation to clinical factors, disease severity, quality of life, gastric retention, and medication use. Gastroenterology 2010;138(Suppl 1):S461.
  45. Tack J, Bisschops R, Sarnelli G. Pathophysiology and treatment of functional dyspepsia. Gastroenterology 2004;127:1239-1255. https://doi.org/10.1053/j.gastro.2004.05.030
  46. Quan C, Talley NJ, Jones MP, Howell S, Horowitz M. Gastrointestinal symptoms and glycemic control in diabetes mellitus: a longitudinal population study. Eur J Gastroenterol Hepatol 2008;20:888-897. https://doi.org/10.1097/MEG.0b013e3282f5f734
  47. Talley SJ, Bytzer P, Hammer J, Young L, Jones M, Horowitz M. Psychological distress is linked to gastrointestinal symptoms in diabetes mellitus. Am J Gastroenterol 2001;96:1033-1038. https://doi.org/10.1111/j.1572-0241.2001.03605.x
  48. Rathmann W, Enck P, Frieling T, Gries FA. Visceral afferent neuropathy in diabetic gastroparesis. Diabetes Care 1991;14:1086-1089. https://doi.org/10.2337/diacare.14.11.1086
  49. Guo JP, Maurer AH, Fisher RS, Parkman HP. Extending gastric emptying scintigraphy from two to four hours detects more patients with gastroparesis. Dig Dis Sci 2001;46:24-29. https://doi.org/10.1023/A:1005697422454
  50. Abell TL, Camilleri M, Donohoe K, et al. Consensus recommendations for gastric emptying scintigraphy: a joint report of the American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine. Am J Gastroenterol 2008;103:753-763. https://doi.org/10.1111/j.1572-0241.2007.01636.x
  51. Choi MG, Camilleri M, Burton DD, Zinsmeister AR, Forstrom LA, Nair KS. [13C]octanoic acid breath test for gastric emptying of solids: accuracy, reproducibility, and comparison with scintigraphy. Gastroenterology 1997;112:1155-1162. https://doi.org/10.1016/S0016-5085(97)70126-4
  52. Viramontes BE, Kim DY, Camilleri M, et al. Validation of a stable isotope gastric emptying test for normal, accelerated or delayed gastric emptying. Neurogastroenterol Motil 2001;13:567-574. https://doi.org/10.1046/j.1365-2982.2001.00288.x
  53. Haruma K, Kusunoki H, Manabe N, et al. Real-time assessment of gastroduodenal motility by ultrasonography. Digestion 2008;77(Suppl 1):S48-S51.
  54. Parkman HP, Camilleri M, Farrugia G, et al. Gastroparesis and functional dyspepsia: excerpts from the AGA/ANMS meeting. Neurogastroenterol Motil 2010;22:113-133. https://doi.org/10.1111/j.1365-2982.2009.01434.x
  55. de Zwart IM, de Roos A. MRI for the evaluation of gastric physiology. Eur Radiol 2010;20:2609-2616. Erratum in: Eur Radiol 2010;20:2609-2616. https://doi.org/10.1007/s00330-010-1850-3
  56. Camilleri M, Malagelada JR. Abnormal intestinal motility in diabetics with the gastroparesis syndrome. Eur J Clin Invest 1984;14:420-427. https://doi.org/10.1111/j.1365-2362.1984.tb01206.x
  57. Chen JD, Lin Z, Pan J, McCallum RW. Abnormal gastric myoelectrical activity and delayed gastric emptying in patients with symptoms suggestive of gastroparesis. Dig Dis Sci 1996;41:1538-1545. https://doi.org/10.1007/BF02087897
  58. Maqbool S, Parkman HP, Friedenberg FK. Wireless capsule motility: comparison of the SmartPill GI monitoring system with scintigraphy for measuring whole gut transit. Dig Dis Sci 2009;54:2167-2174. https://doi.org/10.1007/s10620-009-0899-9
  59. Rao SS, Kuo B, McCallum RW, et al. Investigation of colonic and whole-gut transit with wireless motility capsule and radiopaque markers in constipation. Clin Gastroenterol Hepatol 2009;7:537-544. https://doi.org/10.1016/j.cgh.2009.01.017
  60. Benini L, Castellani G, Brighenti F, et al. Gastric emptying of a solid meal is accelerated by the removal of dietary fibre naturally present in food. Gut 1995;36:825-830. https://doi.org/10.1136/gut.36.6.825
  61. Parrish CR. Nutrition concerns for the patient with gastroparesis. Curr Gastroenterol Rep 2007;9:295-302. https://doi.org/10.1007/s11894-007-0033-0
  62. Haans JJ, Masclee AA. Review article: the diagnosis and management of gastroparesis. Aliment Pharmacol Ther 2007;26(Suppl 2):S37-S46.
  63. Sturm A, Holtmann G, Goebell H, Gerken G. Prokinetics in patients with gastroparesis: a systematic analysis. Digestion 1999;60:422-427. https://doi.org/10.1159/000007687
  64. Bharucha AE, Camilleri M, Forstrom LA, Zinsmeister AR. Relationship between clinical features and gastric emptying disturbances in diabetes mellitus. Clin Endocrinol (Oxf) 2009;70:415-420. https://doi.org/10.1111/j.1365-2265.2008.03351.x
  65. McCallum RW, Ricci DA, Rakatansky H, et al. A multicenter placebo-controlled clinical trial of oral metoclopramide in diabetic gastroparesis. Diabetes Care 1983;6:463-467. https://doi.org/10.2337/diacare.6.5.463
  66. Malagelada JR, Rees WD, Mazzotta LJ, Go VL. Gastric motor abnormalities in diabetic and postvagotomy gastroparesis: effect of metoclopramide and bethanechol. Gastroenterology 1980;78:286-293.
  67. Abell TL, Bernstein RK, Cutts T, et al. Treatment of gastroparesis: a multidisciplinary clinical review. Neurogastroenterol Motil 2006;18:263-283. https://doi.org/10.1111/j.1365-2982.2006.00760.x
  68. Soykan I, Sarosiek I, McCallum RW. The effect of chronic oral domperidone therapy on gastrointestinal symptoms, gastric emptying, and quality of life in patients with gastroparesis. Am J Gastroenterol 1997;92:976-980.
  69. Stevens JE, Russo A, Maddox AF, et al. Effect of itopride on gastric emptying in longstanding diabetes mellitus. Neurogastroenterol Motil 2008;20:456-463. https://doi.org/10.1111/j.1365-2982.2007.01058.x
  70. Kendall BJ, Chakravarti A, Kendall E, Soykan I, McCallum RW. The effect of intravenous erythromycin on solid meal gastric emptying in patients with chronic symptomatic post-vagotomyantrectomy gastroparesis. Aliment Pharmacol Ther 1997;11:381-385. https://doi.org/10.1046/j.1365-2036.1997.148324000.x
  71. Maganti K, Onyemere K, Jones MP. Oral erythromycin and symptomatic relief of gastroparesis: a systematic review. Am J Gastroenterol 2003;98:259-263.
  72. Richards RD, Davenport K, McCallum RW. The treatment of idiopathic and diabetic gastroparesis with acute intravenous and chronic oral erythromycin. Am J Gastroenterol 1993;88:203-207.
  73. Moshiree B, McDonald R, Hou W, Toskes PP. Comparison of the effect of azithromycin versus erythromycin on antroduodenal pressure profiles of patients with chronic functional gastrointestinal pain and gastroparesis. Dig Dis Sci 2010;55:675-683. https://doi.org/10.1007/s10620-009-1038-3
  74. Fraser RJ, Horowitz M, Maddox AF, Dent J. Postprandial antropyloroduodenal motility and gastric emptying in gastroparesis: effects of cisapride. Gut 1994;35:172-178. https://doi.org/10.1136/gut.35.2.172
  75. Asakawa H, Hayashi I, Fukui T, Tokunaga K. Effect of mosapride on glycemic control and gastric emptying in type 2 diabetes mellitus patients with gastropathy. Diabetes Res Clin Pract 2003;61:175-182. https://doi.org/10.1016/S0168-8227(03)00121-9
  76. McCallum RW, Cynshi O. Clinical trial: effect of mitemcinal (a motilin agonist) on gastric emptying in patients with gastroparesisa randomized, multicentre, Placebo-controlled Study. Aliment Pharmacol Ther 2007;26:1121-1130. https://doi.org/10.1111/j.1365-2036.2007.03461.x
  77. McCallum RW, Cynshi O. Efficacy of mitemcinal, a motilin agonist, on gastrointestinal symptoms in patients with symptoms suggesting diabetic gastropathy: a randomized, multi-center, placebocontrolled trial. Aliment Pharmacol Ther 2007;26:107-116. https://doi.org/10.1111/j.1365-2036.2007.03346.x
  78. Murray CD, Martin NM, Patterson M, et al. Ghrelin enhances gastric emptyings in diabetic gastroparesis: a double blind, Placebo Controlled, Crossover Study. Gut 2005;54:1693-1698. https://doi.org/10.1136/gut.2005.069088
  79. Ejskjaer N, Vestergaard ET, Hellstrom PM, et al. Ghrelin receptor agonist (TZP-101) accelerates gastric emptying in adults with diabetes and symptomatic gastroparesis. Aliment Pharmacol Ther 2009;29:1179-1187. https://doi.org/10.1111/j.1365-2036.2009.03986.x
  80. Chong K, Dhatariya K. A case of severe, refractory diabetic gastroparesis managed by prolonged use of aprepitant. Nat Rev Endocrinol 2009;5:285-288. Erratum in: Nat Rev Endocrinol 2009;5:293.
  81. Kim SW, Shin IS, Kim JM, et al. Mirtazapine for severe gastroparesis unresponsive to conventional prokinetic treatment. Psychosomatics 2006;47:440-442. https://doi.org/10.1176/appi.psy.47.5.440
  82. Sawhney MS, Prakash C, Lustman PJ, Clouse RE. Tricyclic antidepressants for chronic vomiting in diabetic patients. Dig Dis Sci 2007;52:418-424. https://doi.org/10.1007/s10620-006-9378-8
  83. Netzer P, Gaia C, Lourens ST, et al. Does intravenous ondansetron affect gastric emptying of a solid meal, gastric electrical activity or blood hormone levels in healthy volunteers? Aliment Pharmacol Ther 2002;16:119-127. https://doi.org/10.1046/j.1365-2036.2002.01152.x
  84. Stacher G, Bergmann H, Schneider C, et al. Effects of the 5-HT3 receptor antagonist ICS 205-930 on fat-delayed gastric emptying and antral motor activity. Br J Clin Pharmacol 1990;30:41-48. https://doi.org/10.1111/j.1365-2125.1990.tb03741.x
  85. Gupta P, Rao SS. Attenuation of isolated pyloric pressure waves in gastroparesis in response to botulinum toxin injection: a case report. Gastrointest Endosc 2002;56:770-772. https://doi.org/10.1016/S0016-5107(02)70140-5
  86. Lacy BE, Crowell MD, Schettler-Duncan A, Mathis C, Pasricha PJ. The treatment of diabetic gastroparesis with botulinum toxin injection of the pylorus. Diabetes Care 2004;27:2341-2347. https://doi.org/10.2337/diacare.27.10.2341
  87. Bromer MQ, Friedenberg F, Miller LS, Fisher RS, Swartz K, Parkman HP. Endoscopic pyloric injection of botulinum toxin A for the treatment of refractory gastroparesis. Gastrointest Endosc 2005;61:833-839. https://doi.org/10.1016/S0016-5107(05)00328-7
  88. Arts J, Holvoet L, Caenepeel P, et al. Clinical trial: a randomizedcontrolled crossover study of intrapyloric injection of botulinum toxin in gastroparesis. Aliment Pharmacol Ther 2007;26:1251-1258. https://doi.org/10.1111/j.1365-2036.2007.03467.x
  89. Friedenberg FK, Palit A, Parkman HP, Hanlon A, Nelson DB. Botulinum toxin A for the treatment of delayed gastric emptying. Am J Gastroenterol 2008;103:416-423. https://doi.org/10.1111/j.1572-0241.2007.01676.x
  90. Cutts TF, Luo J, Starkebaum W, Rashed H, Abell TL. Is gastric electrical stimulation superior to standard pharmacologic therapy in improving GI symptoms, healthcare resources, and long-term health care benefits? Neurogastroenterol Motil 2005;17:35-43. https://doi.org/10.1111/j.1365-2982.2004.00609.x
  91. Lin Z, Sarosiek I, Forster J, McCallum RW. Symptom responses, long-term outcomes and adverse events beyond 3 years of high-frequency gastric electrical stimulation for gastroparesis. Neurogastroenterol Motil 2006;18:18-27. https://doi.org/10.1111/j.1365-2982.2005.00732.x
  92. McCallum RW, Lin Z, Forster J, Roeser K, Hou Q, Sarosiek I. Gastric electrical stimulation improves outcomes of patients with gastroparesis for up to 10 years. Clin Gastroenterol Hepatol 2011;9:314-319. e311. https://doi.org/10.1016/j.cgh.2010.12.013
  93. O'Grady G, Egbuji JU, Du P, Cheng LK, Pullan AJ, Windsor JA. High-frequency gastric electrical stimulation for the treatment of gastroparesis: a meta-analysis. World J Surg 2009;33:1693-1701. https://doi.org/10.1007/s00268-009-0096-1
  94. McCallum RW, Dusing RW, Sarosiek I, Cocjin J, Forster J, Lin Z. Mechanisms of high-frequency electrical stimulation of the stomach in gastroparetic patients. Conf Proc IEEE Eng Med Biol Soc 2006;1:5400-5403.
  95. Kim CH, Nelson DK. Venting percutaneous gastrostomy in the treatment of refractory idiopathic gastroparesis. Gastrointest Endosc 1998;47:67-70. https://doi.org/10.1016/S0016-5107(98)70301-3
  96. Watkins PJ, Buxton-Thomas MS, Howard ER. Long-term outcome after gastrectomy for intractable diabetic gastroparesis. Diabet Med 2003;20:58-63.