Anatomy and Cell Biology

Korean Association of Anatomists (대한해부학회)
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Proapoptotic role of nuclear clusterin in brain

  • Kim, Na-Young (Department of Anatomy and Neurobiology, Medical Research Center for Neural Dysfunction, Institute of Health Science, Gyeongsang National University School of Medicine) ;
  • Choi, Wan-Sung (Department of Anatomy and Neurobiology, Medical Research Center for Neural Dysfunction, Institute of Health Science, Gyeongsang National University School of Medicine)
  • Published : 2011.09.30
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Abstract

Clusterin (CLU) is a multifunctional glycoprotein that has secretory and nuclear isoforms. The two isoforms are known to play opposite roles in cell survival/death. In this review, we summarize recent progress on the pro-apoptotic function of nuclear CLU in vitro and in vivo and discuss previous reports on the role of CLU in brain damage and neurodegeneration.

Keywords

References

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