Korean Circulation Journal

The Korean Society of Cardiology (대한심장학회)
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Arterial Stiffness in Female Patients With Fibromyalgia and Its Relationship to Chronic Emotional and Physical Stress

  • Lee, Ji-Hyun (Divisions of Rheumatology, Maryknoll Medical Center) ;
  • Cho, Kyoung-Im (Divisions of Cardiology, Maryknoll Medical Center) ;
  • Kim, Seong-Man (Divisions of Cardiology, Maryknoll Medical Center) ;
  • Lee, Hyeon-Gook (Divisions of Cardiology, Maryknoll Medical Center) ;
  • Kim, Tae-Ik (Divisions of Cardiology, Maryknoll Medical Center)
  • Published : 2011.10.30
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Abstract

Background and Objectives: In patients with fibromyalgia (FM) syndrome, stress and pain may chronically enhance sympathetic activity, altering cardiovascular responses and inducing the arterial wall-stiffening process. We investigated arterial stiffness in FM patients using pulse wave velocity (PWV) and analyzed whether arterial stiffness was affected by the clinical parameters of FM. Subjects and Methods: This study included 108 female FM patients (51.5${\pm}$8.9 years) without any known cardiovascular diseases and 76 healthy female controls (50.1${\pm}$8.9 years). FM patients underwent a manual tender point survey for tender point counts, and completed the visual analogue scale (VAS) of pain and fibromyalgia impact questionnaire (FIQ), which were composed of a physical and feel score. Brachial-ankle pulse-wave velocity (baPWV) was measured with an automated device. The study participants were subdivided into 2 groups based on the sum of the FIQ score (group A: FIQ ${\geq}$50, group B: <50). Results: Patients with FM had significantly higher baPWV than the controls, and significant increase were noted in baPWV values of group A compared with those of group B. BaPWV showed a significant positive correlation (correlation coefficient=6.83, p=0.022) with severity of disease assessed by FIQ. Conclusion: The patients with FM showed significantly increased arterial stiffness, suggesting a pathophysiologic link between FM and endothelial dysfunction. This study provides a basis for clarifying the mechanism by which chronic pain syndrome is associated with an increased risk of vascular stiffness.

Keywords

References

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