Determinants of Urinary Mercury Concentration among Dental Hygienists

치과위생사들의 요중 수은함량과 관련요인 분석

  • Lee, Myeong-Ju (Department of Dental Hygiene, Masan University) ;
  • Jang, Bong-Ki (Department of Environmental Health Science, Soonchunhyang University) ;
  • Choi, Jae-Ho (Department of Radiological Technology, Ansan University) ;
  • Shim, Hyun-Ju (Department of Environmental Health Science, Soonchunhyang University) ;
  • Lee, Jong-Wha (Department of Environmental Health Science, Soonchunhyang University)
  • Received : 2011.03.30
  • Accepted : 2011.06.09
  • Published : 2011.06.30

Abstract

Objectives: The aim of this study was to evaluate the level of urinary mercury and analyze which factors would affect urinary mercury concentration among dental hygienists in dental clinics. Methods: This study conducted by questionnaire and detection of urinary mercury concentration of 268 dental hygienists working in dental clinics from July to August of 2009. Data collected from two hundred and thirty-five dental hygienists were analyzed by the geometric mean (GM). Analytical results of urine samples with less than 0.3 g creatinine/L and greater than 3g creatinine/L were excluded from statistical analysis. Results: Urinary mercury concentration of 235 dental hygienists showed the geometric distribution. The arithmetic and geometric means of urinary mercury concentration were $0.996{\mu}g/g$ creatinine and $0.755{\mu}g/g$ creatinine, respectively. From multiple regression analysis, the number of amalgam filling, the consumption frequency of raw fish and the number of amalgam handling in current workplace was revealed as increasing factors of urinary mercury concentration. Conclusions: The level of urinary mercury in dental hygienists was higher than in general Korean population. The number of amalgam filling, the consumption frequency of raw fish and the number of amalgam handling in current workplace was revealed as increasing factors of urinary mercury concentration. Therefore using resin materials instead of amalgam in dental clinics is highly desirable.

Keywords

References

  1. 강창수. 치과종사자들의 두발 중 수은함량의 평가. 석사학위논문, 서울대학교 보건대학원, 2007
  2. 국립환경과학원. 생체시료 중 환경오염물질 분석 매뉴얼. 2006
  3. 국립환경과학원. 제3차 국민 생체시료 중 유해물질 실태조사. 2008
  4. 김근배, 김대선, 이종화, 박희진, 위성승. 국내 초등학생의 체내 총수은 농도 및 노출요인 조사. 한국환경보건학회지 2007;33(5):386-391
  5. 김동응, 송근배. 구강내 충전 아말감으로부터 유리되는 수은의 체내축적 양상에 관한 연구. 대한구강보건학회지 1998;22(1):69-78
  6. 김순주, 남미현. 연세대학교 치과대학 치과병원 종사자의 두발 중 수은함량에 대한 연구. 대한소아치과학회지 1991;18(1):163-172
  7. 김찬우, 김영욱, 채창호, 손준석, 박승현 등. 우리나라 일부 지역 주민에서 생선 섭취 빈도가 혈중 수은농도에 미치는 영향. 대한산업의학회지 2010;22(2):114-121
  8. 김형돈. 치과종사자들의 요중 수은농도와 이에 관련된 요인. 석사학위논문, 충남대학교 보건대학원, 1999
  9. 김혜성. 치과의원 종사자들의 체내 수은 축적과 신장기능과의 관련에 대한 연구. 석사학위논문, 서울대학교, 1999
  10. 박수빈. 치과의료기관 근무자들의 아말감 사용과 요중 수은농도의 관련성. 석사학위논문, 영남대학교 환경보건대학원, 2009
  11. 송경희, 김두희, 이종영. 치과 진료실내 수은오염도 및 치과의사의 두발 중 수은 함량. 대한산업의학회지 1991;3:21-31
  12. 식품의약품안전청. 한국인의 대표식품 중 오염물질 섭취량 및 위해도 평가. 2006
  13. 신경희. 치과의료기관 종사자의 치과용 아말감 수은에 대한 인식 고찰. 대한치과위생학회지 2005;7(1):67-84
  14. 오새미. 치과용 아말감 충전재와 대체물질의 안전성에 관한 연구. 석사학위논문, 전남대학교 치의학전문대학원, 2009
  15. 이원식, 김두희. 어패류와 그 제품 섭취양상에 따른 두발 중 총 수은 및 유기수은 함량. 예방의학회지 1994; 27(1):44-58
  16. 한국치과치료학교수협의회. 치과재료학. 5판, 서울: 군자출판사; 2008
  17. 황윤숙, 정규철. 우리나라 치과위생사의 머리칼속의 수은함량. 대한구강보건학회지 1995;19(3):383-384
  18. Agusa T, Kunito T, Iwata H, Monirith I, Tana TS et al. Mercury contamination in human hair and fish from Cambodia: levels, specific accumulation and risk assessment. Environ Pollut 2005;134(1):79-86 https://doi.org/10.1016/j.envpol.2004.07.015
  19. American Dental Association. Dental mercury hygiene recommendations. J Am Dent Assoc 1999; 130(7): 1125-1126 https://doi.org/10.14219/jada.archive.1999.0348
  20. Aposhian HV, Bruce DC, Alter RC, Dart W, Hurlbut KM et al. Urinary mercury after administration of 2,3- dimercapopropane-1-sulfonic acid: correlation with dental amalgam score. FASEB J 1992;6(7):2472-2476
  21. Apostoli P, Cortesi I, Mangili A, Elia G, Drago I et al. Assessment of reference values for mercury in urine: the results of an Italian polycentric study. Sci Total Environ 2002;289(1-3):13-24 https://doi.org/10.1016/S0048-9697(01)01013-0
  22. Barr DB, Wilder LC, Caudill SP, Gonzalez AJ, Needham LL et al. Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements. Environ Health Perspect 2005; 113(2):192-200
  23. Bates MN, Fawcett J, Garrett N, Cutress T, Kjellstrom T. Health effects of dental amalgam exposure: a retrospective cohort study. Int J Epidemiol 2004; 33(4):894-902 https://doi.org/10.1093/ije/dyh164
  24. Baum L, Phillips RW, Lund MR. Textbook of Operative Dentistry. 2nd ed., Philadelphia: WB Saunders; 1985
  25. Begerow J, Zander D, Freier I, Dunemann L. Long-term mercury excretion in urine after removal of amalgam fillings. Int Arch Occup Environ Health 1994;66(3): 209-212 https://doi.org/10.1007/BF00380782
  26. Calafat AM, Needham LL, Silva MJ, Lambert G. Exposure to di-(2-ethylhexyl) phthalate among premature neonates in a neonatal intensive care unit. Pediatrics 2004;113(5):e429-434 https://doi.org/10.1542/peds.113.5.e429
  27. Centers for Disease Control (CDC). Third national report on human exposure to environmental chemicals. Department of Health and Human Services Centers for Disease Control and Prevention, 2005, pp. 47-48
  28. Centers for Disease Control (CDC). Third national report on human exposure to environmental chemicals. Department of Health and Human Services Centers for Disease Control and Prevention, 2010, p. 47
  29. Drasch G, Schupp I, Hofl H, Reinke R, Roider G. Mercury burden of human fetal and infant tissues. Eur J Pediatr 1994;153:607-610 https://doi.org/10.1007/BF02190671
  30. Gochfeld M. Cases of mercury exposure, bioavailability, and absorption. Ecotoxicol Environ Saf 2003;56(1):174-179 https://doi.org/10.1016/S0147-6513(03)00060-5
  31. Halbach S, Vogt S, Köhler W, Felgenhauer N, Welzl G et al. Blood and urine mercury levels in adult amalgam patients of a randomized controlled trial: interaction of Hg species in erythrocytes. Environ Res 2008;107(1):69-78 https://doi.org/10.1016/j.envres.2007.07.005
  32. Harakeh S, Sabra N, Kassak K, Doughan B. Factors influencing total mercury levels among Lebanese dentists. Sci Total Environ 2002;297(1-3):153-160 https://doi.org/10.1016/S0048-9697(02)00131-6
  33. Horsted-Bindslev P. Amalgam toxicity-environmental and occupational hazards. J Dent 2004;32(5):359-365 https://doi.org/10.1016/j.jdent.2004.02.002
  34. Houston MC. The role of mercury and cadmium heavy metals in vascular disease, hypertension, coronary heart disease, and myocardial infarction. Altern Ther Health Med 2007;13(2):128-133
  35. Ip P, Wong V, Ho M, Lee J, Wong W. Environmental mercury exposure in children: South China's experience. Pediatr Int 2004;46(6):715-721 https://doi.org/10.1111/j.1442-200x.2004.01972.x
  36. Jo EM, Kim BG, Kim YM, Yu SD, You CH, Kim JY, Hong YS. Blood mercury concentration and related factors in an urban coastal area in Korea. J Prev Med Public Health 2010;43:377-386 https://doi.org/10.3961/jpmph.2010.43.5.377
  37. Johnsson C, Sallsten G, Schutz A, Sjors A, Barregard L. Hair mercury levels versus freshwater fish consumption in household members of Swedish angling societies. Environ Res 2004;96(3):257-263 https://doi.org/10.1016/j.envres.2004.01.005
  38. Kim IK, Kwon JY, Kim SW, Park YW. The effect of fish consumption on blood mercury levels in pregnant women. Yonsei Med J 2006;47(5):626-633 https://doi.org/10.3349/ymj.2006.47.5.626
  39. Levy M, Schwartz S, Dijak M, Weber JP, Tardif R et al. Childhood urine mercury excretion: dental amalgam and fish consumption as exposure factors. Environ Res 2004;94(3):283-290 https://doi.org/10.1016/j.envres.2003.07.004
  40. Meeker JD, Barr DB, Hauser R. Thyroid hormones in relation to urinary metabolites of non-persistent insecticides in men of reproductive age. Reprod Toxicol 2006;22(3):437-442 https://doi.org/10.1016/j.reprotox.2006.02.005
  41. Ministry of Health, Labour and Welfare. Advice for pregnant women on fish consumption concerning mercury contamination. A vailable: http://www.mhlw.go.jp/english/wp/other/councils/ mercury/cited 3 June 2003
  42. Morata WI, Sohn MA, EI-Defrawy MM, Faragat SE.Reference intervals of cadmium, lead, and mercury in blood, urine, hair, and nails among residents in Mansoura city, Nile Delta, Egypt. Environ Res 2002;90(2):104-110 https://doi.org/10.1006/enrs.2002.4396
  43. Mutter J, Naumann J, Walach H, Daschner F. Amalgam risk assessment with coverage of references up to 2005. Gesundheitswesen 2005;67(3):204-216 https://doi.org/10.1055/s-2005-857962
  44. Naleway C, Sakaguchi R, Mitchell E, Muller T, Ayer WA et al. Urinary mercury level in U.S. dentist, 1975-1983: review of health assessment program. J Am Dent Assoc 1985;111:37-42 https://doi.org/10.14219/jada.archive.1985.0069
  45. Nilsson B. Mercury in dental practice II: urinary mercury excretion in dental personnel. J Dent 1986;10(6): 221-232
  46. Smart ER. A survey of mercury vapor levels ill general dental practice. International Conference on Mercury Hazards and Dental Practice, Glasgow, Senl land, 1981
  47. Song KB. Mercury toxicity from dental amalgam: a review. J Korean Acad Dent Health 1995;19(4):419- 438
  48. Tchounwou PB, Ayensu WK, Ninashvili N, Sutton D. Environmental exposure to mercury and its toxicopathologic implications for public health. Environ Toxicol 2003;18(3):149-175 https://doi.org/10.1002/tox.10116
  49. Travnikov O, Ryaboshapko A. Modelling of mercury hemispheric transport and depositions. MSC-E Technical Report, 2002
  50. U.S. Food and Drug Administration. What you need to know about mercury in fish and shellfish (brochure). Available: http://www.fda.gov/Food/ResourcesForYou/Consumers/ ucm110591.htm [cited 15 September 2009]
  51. Vahter M, Akesson A, Lind B, Bjors U, Schutz A et al. Longitudinal study of methylmercury and inorganic mercury in blood and urine of pregnant and lactating women, as well as in umbilical cord blood. Environ Res 2000;84(2):186-194 https://doi.org/10.1006/enrs.2000.4098
  52. WHO (World Health Organization). Methylmercury. IPCSEnvironmental Health Criteria, No. 101, WHO, Geneva, 1990
  53. Woods JS, Martin MD, Leroux BG, DeRouen TA, Leitao JG et al. The contribution of dental amalgam to urinary mercury excretion in children. Environ Health Perspect 2007;115(10):1527-1531