DOI QR코드

DOI QR Code

Application of Helical Tomotherapy for Two Cases of Advanced Hepatocellular Carcinoma

  • Kim, Joon-Sung (Department of Internal Medicine, The Catholic University of Korea School of Medicine) ;
  • You, Chan-Ran (Department of Internal Medicine, The Catholic University of Korea School of Medicine) ;
  • Jang, Jeong-Won (Department of Internal Medicine, The Catholic University of Korea School of Medicine) ;
  • Bae, Si-Hyun (Department of Internal Medicine, The Catholic University of Korea School of Medicine) ;
  • Choi, Jong-Yong (Department of Internal Medicine, The Catholic University of Korea School of Medicine) ;
  • Yoon, Seung-Kew (Department of Internal Medicine, The Catholic University of Korea School of Medicine) ;
  • Kay, Chul-Seung (Department of Radiation Oncology, The Catholic University of Korea School of Medicine)
  • 발행 : 2011.06.01

초록

The role of radiotherapy in the treatment of hepatocellular carcinoma (HCC) has been limited to date, because the liver has a low tolerance to radiation. However, reconstructing tumors and surrounding organs via a three-dimensional conformal planning system can avoid excess radiotherapy exposure to the rest of the liver and adjacent organs. Recently, the concept of "adaptive radiotherapy," such as with helical tomotherapy, has been introduced for treating HCC. Helical tomotherapy obtains an image from the computed tomography component, which allows targeted regions to be visualized prior to, during, and immediately after each treatment and delivers intensity-modulated radiation therapy. We report two patients with advanced HCC who underwent tomotherapy treatment. One was a patient afflicted with advanced HCC and a portal vein tumor thrombus, which was treated with tomotherapy combined with transarterial chemolipiodolization. The other was a patient afflicted with multiple pulmonary metastases treated with tomotherapy followed by systemic chemotherapy.

키워드

참고문헌

  1. Price J, Chan M, Hamilton-Wood C, Chronos NA, Mok SD, Metreweli C. Sonographic diagnosis of portal vein invasion in patients with hepatocellular carcinoma: comparison with arterial portography. Clin Radiol 1990;41:9-12. https://doi.org/10.1016/S0009-9260(05)80923-7
  2. Urata K, Matsumata T, Kamakura T, Hasuo K, Sugimachi K. Lipiodolization for unresectable hepatocellular carcinoma: an analysis of 205 patients using univariate and multivariate analysis. J Surg Oncol 1994;56:54-58. https://doi.org/10.1002/jso.2930560113
  3. Lam CM, Lo CM, Yuen WK, Liu CL, Fan ST. Prolonged survival in selected patients following surgical resection for pulmonary metastasis from hepatocellular carcinoma. Br J Surg 1998;85:1198-1200. https://doi.org/10.1046/j.1365-2168.1998.00846.x
  4. Natsuizaka M, Omura T, Akaike T, et al. Clinical features of hepatocellular carcinoma with extrahepatic metastases. J Gastroenterol Hepatol 2005;20:1781-1787. https://doi.org/10.1111/j.1440-1746.2005.03919.x
  5. Nakagawa T, Kamiyama T, Nakanishi K, et al. Pulmonary resection for metastases from hepatocellular carcinoma: factors influencing prognosis. J Thorac Cardiovasc Surg 2006;131:1248-1254. https://doi.org/10.1016/j.jtcvs.2006.02.009
  6. Seong J, Keum KC, Han KH, et al. Combined transcatheter arterial chemoembolization and local radiotherapy of unresectable hepatocellular carcinoma. Int J Radiat Oncol Biol Phys 1999;43:393-397. https://doi.org/10.1016/S0360-3016(98)00415-5
  7. Mackie TR, Holmes T, Swerdloff S, et al. Tomotherapy: a new concept for the delivery of dynamic conformal radiotherapy. Med Phys 1993;20:1709-1719. https://doi.org/10.1118/1.596958
  8. Wharton JT, Delclos L, Gallager S, Smith JP. Radiation hepatitis induced by abdominal irradiation with the cobalt 60 moving strip technique. Am J Roentgenol Radium Ther Nucl Med 1973;117:73-80. https://doi.org/10.2214/ajr.117.1.73
  9. Llovet JM, Real MI, Montana X, et al. Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial. Lancet 2002;359:1734-1739. https://doi.org/10.1016/S0140-6736(02)08649-X
  10. Shiina S, Tagawa K, Unuma T, et al. Percutaneous ethanol injection therapy of hepatocellular carcinoma: analysis of 77 patients. AJR Am J Roentgenol 1990;155:1221-1226. https://doi.org/10.2214/ajr.155.6.2173384
  11. Jang JW, Kay CS, You CR, et al. Simultaneous multitarget irradiation using helical tomotherapy for advanced hepatocellular carcinoma with multiple extrahepatic metastases. Int J Radiat Oncol Biol Phys 2009;74:412-418. https://doi.org/10.1016/j.ijrobp.2008.08.034

피인용 문헌

  1. 한의학과 아유르베다에서의 설진(舌診)에 대한 비교 연구 vol.40, pp.2, 2011, https://doi.org/10.13048/jkm.19017